Patents by Inventor Laura Zaccaro

Laura Zaccaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective ??receptor peptide antagonist for therapeutic and diagnostic applications
    Patent number: 9309288
    Abstract: The present invention is related to new peptide antagonists of ?v?3 receptor, designed on the basis of the crystal structure of integrin ?v?3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the ?v?3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for ?v?3-targeted therapy and imaging.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: April 12, 2016
    Assignee: ADVANCED ACCELERATOR APPLICATIONS
    Inventors: Annarita Del Gatto, Laura Zaccaro, Carlo Pedone, Michele Saviano
  • SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
    Publication number: 20140094412
    Abstract: The present invention is related to new peptide antagonists of ?v?3 receptor, designed on the basis of the crystal structure of integrin ?v?3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the ?v?3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for ?v?3-targeted therapy and imaging.
    Type: Application
    Filed: August 30, 2013
    Publication date: April 3, 2014
    Applicant: Advanced Accelerator Applications
    Inventors: Annarita DEL GATTO, Laura ZACCARO, Carlo PEDONE, Michele SAVIANO
  • Selective ?v?3 receptor peptide antagonist for therapeutic and diagnostic applications
    Patent number: 8546526
    Abstract: The present invention is related to new peptide antagonists of ?v?3 receptor, designed on the basis of the crystal structure of integrin ?v?3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the ?v?3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for ?v?3-targeted therapy and imaging.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: October 1, 2013
    Assignee: Advanced Accelerator Applications
    Inventors: Annarita del Gatto, Laura Zaccaro, Carlo Pedone, Michele Saviano
  • Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders
    Patent number: 8461110
    Abstract: Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: June 11, 2013
    Assignee: Blueprint Pharma S.R.L.
    Inventors: Luigi Vitagliano, Laura Zaccaro, Giancarlo Morelli, Enzo Martegani
  • Heterodimeric Peptide Compounds Displaying Ngf Activity and Their Use to Treat Neurodegenerative Disorders
    Publication number: 20090318335
    Abstract: Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.
    Type: Application
    Filed: June 9, 2006
    Publication date: December 24, 2009
    Inventors: Luigi Vitagliano, Laura Zaccaro, Giancarlo Morelli, Enzo Martegani
  • Selective Alfavbetas Receptor Peptide Antagonist for Therapeutic and Diagnostic Applications
    Publication number: 20080213190
    Abstract: The present invention is related to new peptide antagonists of ?v?3 receptor, designed on the basis of the crystal structure of integrin ?v?3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the ?v?3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for ?v?3-targeted therapy and imaging.
    Type: Application
    Filed: October 9, 2006
    Publication date: September 4, 2008
    Inventors: Annarita Del Gatto, Laura Zaccaro, Carlo Pedone, Michele Saviano