Patents by Inventor Laure Aurelian

Laure Aurelian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INHIBITING PROINFLAMMATORY NEUROIMMUNE SIGNALING AND TREATING INFLAMMATORY DISORDERS
    Publication number: 20210205329
    Abstract: Methods of inhibiting proinflammatory neuroimmune signaling as is related to the treatment of inflammatory disorders are provided. These methods include the inhibiting of toll-like receptor signaling and/or the enhancement of anti-inflammatory signaling, and in one example, the inhibiting of TLR2, TLR4 or TLR7 signaling as well as the enhancement of fracktalkine or IL-10 signaling either alone or together.
    Type: Application
    Filed: May 20, 2019
    Publication date: July 8, 2021
    Inventors: A. Leslie Morrow, Laure Aurelian, Irina Balan
  • Methods and compositions for treating cancer
    Patent number: 8414885
    Abstract: The invention relates to a method of treating cancer, comprising administering to a subject in need thereof an effective amount of a HSV-2 virus, wherein the virus lacks protein kinase activity of ICP10. The invention further relates to pharmaceutical compositions comprising HSV-2 virus, wherein the virus lacks protein kinase activity of ICP10.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: April 9, 2013
    Assignee: University of Maryland, Baltimore
    Inventors: Laure Aurelian, Aric Colunga, Jennifer Laing
  • PREVENTION OF RECURRENT VIRAL DISEASE
    Publication number: 20110059134
    Abstract: The present invention discloses compositions and methods for ameliorating or reducing recurrent viral disease, which compositions and methods result in an increase in virus specific immunoglobulin subclasses reflective of a preferential Th1 response.
    Type: Application
    Filed: June 23, 2008
    Publication date: March 10, 2011
    Inventors: Laure Aurelian, Takahiro Gyotoku, Gary J. Calton
  • Protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp 10pk) has anti-apoptotic activity
    Patent number: 7482318
    Abstract: The invention relates to a method of treating neuronal apoptosis in a mammal using nucleic acid encoding HSV-2 ICP10PK, or a polypeptide encoded thereby. The invention further relates to a method of treating neuronal apoptosis in a mammal using ICP10PK in combination with a nucleic acid encoding bcl-2, or the polypeptide encoded thereby. The invention also relates to the use of ICP10PK and ICP10PK in combination with bcl-2 to treat non-neuronal diseases characterized by apoptosis.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: January 27, 2009
    Assignee: University of Maryland, Baltimore
    Inventors: Laure Aurelian, Dana Perkins, Cynthia Smith
  • Prevention of recurrent viral disease
    Publication number: 20040220076
    Abstract: The present invention discloses compositions and methods for ameliorating or reducing recurrent viral disease, which compositions and methods result in an increase in virus specific immunoglobulin subclasses reflective of a preferential Th1 response.
    Type: Application
    Filed: November 10, 2003
    Publication date: November 4, 2004
    Inventors: Laure Aurelian, Takahiro Gyotoku, Gary J Calton
  • Protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp10pk) has anti-apoptotic activity
    Publication number: 20040053868
    Abstract: The invention relates to a method of treating neuronal apoptosis in a mammal using nucleic acid encoding HSV-2 ICP10PK, or a polypeptide encoded thereby. The invention further relates to a method of treating neuronal apoptosis in a mammal using ICP10PK in combination with a nucleic acid encoding bcl-2, or the polypeptide encoded thereby. The invention also relates to the use of ICP10PK and ICP10PK in combination with bcl-2 to treat non-neuronal diseases characterized by apoptosis.
    Type: Application
    Filed: January 22, 2003
    Publication date: March 18, 2004
    Inventors: Laure Aurelian, Dana Perkins, Cynthia Smith
  • Prevention of recurrent viral disease
    Publication number: 20020094337
    Abstract: The present invention discloses compositions and methods for ameliorating or reducing recurrent viral disease, which compositions and methods result in an increase in virus specific immunoglobulin subclasses reflective of a preferential Th1 response.
    Type: Application
    Filed: November 16, 2001
    Publication date: July 18, 2002
    Applicant: University of Maryland, Baltimore
    Inventors: Laure Aurelian, Takahiro Gyotoku
  • Vaccine composition for herpes simplex virus and methods of using
    Patent number: 6207168
    Abstract: The present invention discloses a new vaccine composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: March 27, 2001
    Assignee: University of Maryland at Baltimore
    Inventor: Laure Aurelian
  • Anti-viral and immuno stimulator polynucleotide duplex and use thereof
    Patent number: 6080726
    Abstract: A method of treating HSV-2 infection which comprises administering to a host subject to said infection an effective amount of a polynucleotide of the formula polyrI.polyr(C.sub.12 U) where n is an integer from 4 to 29. The polynucleotide is advantageously administered intranasally.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: June 27, 2000
    Assignees: University of Maryland, Johns Hopkins University
    Inventors: Paul O. P. Ts'o, Laure Aurelian
  • Vaccine composition for herpes simplex virus and method of using
    Patent number: 6054131
    Abstract: The present invention discloses a new immunogenic composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: April 25, 2000
    Assignee: University of Maryland Baltimore
    Inventor: Laure Aurelian
  • Vaccine composition for herpes simplex virus and methods of using
    Patent number: 6013265
    Abstract: The present invention discloses a new vaccine composition for HSV-1 and HSV-2 comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: January 11, 2000
    Assignee: University of Maryland, Baltimore
    Inventor: Laure Aurelian
  • Herpes simplex virus type specific seroassay
    Patent number: 5965356
    Abstract: A recombinant virus (ICP10.DELTA.RR) has been developed which is useful in a Western blot assay to specifically detect antibody to HSV-2, even the presence of co-existing antibody to HSV-1.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: October 12, 1999
    Assignee: University of Maryland, Baltimore
    Inventors: Laure Aurelian, Cynthia Smith
  • Serological assay for herpes
    Patent number: 5919616
    Abstract: The present method relates to the serological detection of herpes simplex virus type 2 (HSV-2) infection by means of reaction of a patient serum with a peptide specific to HSV-2 having the sequence Ala-Arg-Ser-Pro-Glu -Arg-Gln-Glu-Pro-Arg-Glu-Pro-Glu. The peptide may be further modified by the addition of a Cys or a biotin molecule. The peptide may be used in any of a number of assays including enzyme linked immunosorbent assay (ELISA), a radioimmunoassay (RIA), and other forms of immunoassay such as enzyme immunoblotting assay on a suitable adsorbent paper or an agglutination assay using the peptide composition as the antigen.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: July 6, 1999
    Assignee: AuRx, Inc.
    Inventors: Laure Aurelian, Gary J. Calton
  • 6-amino-1,2-benzopyrones useful for treatment of viral diseases
    Patent number: 5583155
    Abstract: Unsubstituted or substituted 6-amino-1,2-benzopyrones are potent, selective and non-toxic inhibitors and suppressants of viral infections in a mammalian host. The compounds are particularly useful for treatment of AIDS, herpetic episodes and cytomegaloviral infections. The method of treatment of viral diseases by 6-amino-1,2-benzopyrones is described.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: December 10, 1996
    Assignee: Octamer, Inc.
    Inventors: Ernest Kun, Laure Aurelian
  • Acyl-carnitine for the treatment and prevention of viral infections
    Patent number: 5314689
    Abstract: Acyl-Carnitine in pharmaceutical formulations provides therapeutic and preventive antiviral action against HSV, CMV, VZV, HIV and others.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: May 24, 1994
    Assignee: Attilio Bernardini
    Inventors: Laura Scandurra, Laure Aurelian