Abstract: The present invention relates to in vivo methods of delivering recombinant virions or viral vectors to a subject, including a human diagnosed with or suspected of having liver fibrosis. The disclosure also relates to methods in which recombinant virions, such as AAV virions, are introduced into the myofibroblasts of the liver and to deliver therapeutic nucleic acids, including those nucleic acids necessary to differentiate a myofibroblast into a hepatocyte, thereby not only improving liver function but also reducing collagen deposition and thus liver fibrosis.

Abstract: The present invention relates to an injectable preparation comprising particles or fibrils with length less than 10 ?m and at least one pharmaceutically acceptable vehicle or excipient. The particles or fibrils comprise proteins or peptides inducing adhesion and activation of the platelets, or even aggregation thereof. The preparation is useful for treating hemorrhages.

Abstract: A method for diagnosing von Willebrand disease and novel polypeptides which bind to von Willebrand factor.

Abstract: The present invention relates to an injectable preparation comprising particles or fibrils with length less than 10 ?m and at least one pharmaceutically acceptable vehicle or excipient. The particles or fibrils comprise proteins or peptides inducing adhesion and activation of the platelets, or even aggregation thereof. The preparation is useful for treating haemorrhages.

Abstract: A method for diagnosing von Willebrand disease and novel polypeptides which bind to von Willebrand factor.

Abstract: A rolling element bearing comprises an inner ring and an outer ring which are each provided with a raceway, and a series of rolling elements which are in contact with the raceways of each ring. A lubricant film is provided in the contacts between the rolling elements and the raceways, which film forms a lubricant meniscus at the inlet side of each contact. In the bearing starved lubrication conditions prevail. The surface of each rolling element has minute recesses filled with a lubricant quantity, said recesses being flattened in the contact area defined by the contact between the rolling elements and the rings and thereby releasing lubricant at the inlet side of each contact resulting in a displacement of the meniscus further away from said contact. This meniscus displacement results in an increased lubricant film thickness in each contact area, thus improving the lubricating conditions in the bearing.

Abstract: A rolling element bearing comprises an inner ring and an outer ring which are each provided with a raceway, and a series of rolling elements which are in contact with the raceways of each ring. A lubricant film is provided in the contacts between the rolling elements and the raceways, which film forms a lubricant meniscus at the inlet side of each contact. In the bearing starved lubrication conditions prevail. The surface of each rolling element has minute recesses filled with a lubricant quantity, said recesses being flattened in the contact area defined by the contact between the rolling elements and the rings and thereby releasing lubricant at the inlet side of each contact resulting in a displacement of the meniscus further away from said contact. This meniscus displacement results in an increased lubricant film thickness in each contact area, thus improving the lubricating conditions in the bearing.

Abstract: A rolling element bearing comprises an inner ring and an outer ring which are each provided with a raceway, and a series of rolling elements which are in contact with the raceways of each ring. A lubricant film is provided in the contacts between the rolling elements and the raceways, which film forms a lubricant meniscus at the inlet side of each contact. In the bearing starved lubrication conditions prevail. The surface of each rolling element has minute recesses filled with a lubricant quantity, said recesses being flattened in the contact area defined by the contact between the rolling elements and the rings and thereby releasing lubricant at the inlet side of each contact resulting in a displacement of the meniscus further away from said contact. This meniscus displacement results in an increased lubricant film thickness in each contact area, thus improving the lubricating conditions in the bearing.

Abstract: A rolling element bearing comprises an inner ring and an outer ring which are each provided with a raceway, and a series of rolling elements which are in contact with the raceways of each ring. A lubricant film is provided in the contacts between the rolling elements and the raceways, which film forms a lubricant meniscus at the inlet side of each contact. In the bearing starved lubrication conditions prevail. The surface of each rolling element has minute recesses filled with a lubricant quantity, said recesses being flattened in the contact area defined by the contact between the rolling elements and the rings and thereby releasing lubricant at the inlet side of each contact resulting in a displacement of the meniscus further away from said contact. This meniscus displacement results in an increased lubricant film thickness in each contact area, thus improving the lubricating conditions in the bearing.