Patents by Inventor Laurel Sillerud

Laurel Sillerud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10827946
    Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: November 10, 2020
    Assignee: UNM Rainforest Innovations
    Inventors: Shihoko Kimura-Ohba, Laurel Sillerud
  • Patent number: 10466326
    Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: November 5, 2019
    Assignee: STC. UNM
    Inventor: Laurel Sillerud
  • Publication number: 20180249926
    Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.
    Type: Application
    Filed: August 31, 2016
    Publication date: September 6, 2018
    Applicant: STC.UNM
    Inventors: Shihoko Kimura-Ohba, Laurel Sillerud
  • Publication number: 20180143278
    Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.
    Type: Application
    Filed: May 13, 2016
    Publication date: May 24, 2018
    Applicant: STC.UNM
    Inventor: Laurel Sillerud
  • Patent number: 9958516
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: May 1, 2018
    Assignees: ABQMR, Inc., Sandia Corporation, STC.UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Patent number: 9194921
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: November 24, 2015
    Assignees: STC.UNM, Sandia Corporation, ABQMR, Inc.
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Patent number: 9110067
    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 18, 2015
    Assignee: The Regents of the University of New Mexico
    Inventor: Laurel Sillerud
  • Patent number: 9110068
    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: August 18, 2015
    Assignee: The Regents of the University of New Mexico
    Inventor: Laurel Sillerud
  • Publication number: 20140295486
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Application
    Filed: March 26, 2014
    Publication date: October 2, 2014
    Applicant: STC.UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Publication number: 20140287436
    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid, when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.
    Type: Application
    Filed: June 6, 2014
    Publication date: September 25, 2014
    Inventor: Laurel Sillerud
  • Publication number: 20140273005
    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventor: Laurel Sillerud
  • Patent number: 8698494
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: April 15, 2014
    Assignee: STC.UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Patent number: 8384381
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: February 26, 2013
    Assignee: STC . UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Patent number: 8339135
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: December 25, 2012
    Assignee: STC.UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Publication number: 20120112744
    Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use.
    Type: Application
    Filed: January 20, 2012
    Publication date: May 10, 2012
    Inventors: Andrew F. McDowell, Eiichi Fukushima, Victor Esch, Meghan Norvell, Laurel Sillerud
  • Patent number: 8143896
    Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use. In certain embodiments, the invention provides a module including a microcoil possessing an inner diameter of between 25 microns and 550 microns, a conduit disposed proximate to the microcoil, in which the conduit is in fluid communication with a sample reservoir, an affinity column in fluid communication with the conduit and the sample reservoir, and a connector for connecting the module to a magnetic resonance detector.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: March 27, 2012
    Assignees: ABQMR, Inc., NanoMR, Inc.
    Inventors: Andrew F McDowell, Eiichi Fukushima, Victor Esch, Meghan Norvell, Laurel Sillerud
  • Publication number: 20100219824
    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 2, 2010
    Applicant: STC.UNM
    Inventors: Laurel Sillerud, Todd M. Alam, Andrew F. McDowell
  • Publication number: 20090146658
    Abstract: The present invention provides microcoil magnetic resonance based modules, detection devices, and methods for their use.
    Type: Application
    Filed: October 23, 2008
    Publication date: June 11, 2009
    Applicants: ABQMR, INC., NANOMR, INC.
    Inventors: Andrew F. McDowell, Eiichi Fukushima, Victor Esch, Meghan Norvell, Laurel Sillerud
  • Publication number: 20060140871
    Abstract: Paramagnetic or superparamagnetic nanoparticle-ligand conjugates that include a recognition ligand that interacts with a component on the surface of a prostate cancer cell. Nanoparticle-ligand conjugates of the invention may be used for magnetic resonance imaging of prostate cancer, or for treatment of tumors by targeted thermal ablation.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 29, 2006
    Inventor: Laurel Sillerud
  • Publication number: 20050048579
    Abstract: The invention provides tertiary structures of cyclic nonapeptide ICAM-1 inhibitors and methods of using the tertiary structures to identify additional ICAM-1 inhibitors, particularly non-peptide modulators. The invention also provides methods of treating ICAM-1/LFA-1 mediated diseases comprising administering a non-peptide ICAM-1 modulator of the invention to a patient in need thereof.
    Type: Application
    Filed: July 7, 2004
    Publication date: March 3, 2005
    Inventors: Richard Larson, Laurel Sillerud