Patents by Inventor Laurence A. Harker

Laurence A. Harker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5709874
    Abstract: A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: January 20, 1998
    Assignee: Emory University
    Inventors: Stephen R. Hanson, Neal A. Scott, Spencer B. King, III, Laurence A. Harker
  • Patent number: 5523092
    Abstract: A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: June 4, 1996
    Assignee: Emory University
    Inventors: Stephen R. Hanson, Neal A. Scott, Spencer B. King, III, Laurence A. Harker
  • Patent number: 5383928
    Abstract: This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: January 24, 1995
    Assignee: Emory University
    Inventors: Neal A. Scott, Stephen R. Hanson, Spencer B. King, III, Laurence A. Harker
  • Patent number: 5345932
    Abstract: A method for determining the concentration of a constituent of blood employing a sensor in or near a catheter in a blood vessel for producing a signal related to the concentration of the constituent of blood is disclosed. The improvement comprises obtaining the signal while at least one of the following is present in the blood vessel: (1) an added vasodilator component and/or vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of the catheter in the blood vessel and (2) an added platelet/white cell inhibitor component and/or a platelet/white cell deactivation promotor in an amount effective to reduce the platelet and/or white cell activation caused by the presence of the catheter in the blood vessel.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: September 13, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Masao Yafuso, Laurence A. Harker
  • Patent number: 5195963
    Abstract: A method for determining the concentration of a constituent of blood employing a sensor in or near a catheter in a blood vessel for producing a signal related to the concentration of the constituent of blood is disclosed. The improvement comprises obtaining the signal while at least one of the following is present in the blood vessel: (1) an added vasodilator component and/or vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of the catheter in the blood vessel and (2) an added platelet/white cell inhibitor component and/or a platelet/white cell deactivation promotor in an amount effective to reduce the platelet and/or white cell activation caused by the presence of the catheter in the blood vessel.
    Type: Grant
    Filed: January 14, 1992
    Date of Patent: March 23, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Masao Yafuso, Laurence A. Harker
  • Patent number: 4929602
    Abstract: The present invention contemplates a method of preventing platelet dependent arterial thrombosis using a halogen-methyl ketone-containing peptide represented by Formula (1) as shown in FIG. 1, or a hydrohalic addition product thereof. More particularly, the present invention provides improved methods for inhibiting arterial restenosis, hemodialysis and the like.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: May 29, 1990
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Laurence A. Harker, Stephen R. Hanson
  • Patent number: 4206214
    Abstract: Pharmaceutical dosage unit compositions containing, as a combination of active ingredients, dipyridamole and sulfinpyrazone, and a method of using the same as antithrombotics.
    Type: Grant
    Filed: August 1, 1978
    Date of Patent: June 3, 1980
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Laurence A. Harker, Hans W. Schroter, Walter Haarmann, Josef Roch