Patents by Inventor Laurence Barker

Laurence Barker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying improved conjugates of biologically active compounds
    Patent number: 8357506
    Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: January 22, 2013
    Inventors: Michael Burnet, Jan-Hinrich Guse, Gene Kim, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Laurence Barker, Michael Wolff, Hans-Jurgen Gutke
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Patent number: 7579324
    Abstract: This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: August 25, 2009
    Assignee: c-a-i-r biosciences GmbH
    Inventors: Michael Burnet, Jan-Hinrich Guse, Hans-Jurgen Gutke, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Jeannette Reichert, Kattie Luyten, Maximilian Busch, Michael Wolff, Moussa Khobzaoui, Simona Margutti, Thomas Meindl, Gene Kim, Laurence Barker
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Publication number: 20090093014
    Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
    Type: Application
    Filed: June 12, 2008
    Publication date: April 9, 2009
    Inventors: Michael Burnet, Jan-Hinrich Guse, Gene Kim, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Laurence Barker, Michael Wolff, Hans-Jurgen Gutke
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Publication number: 20080145343
    Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
    Type: Application
    Filed: August 23, 2007
    Publication date: June 19, 2008
    Inventors: Michael Burnet, Jan-Hinrich Guse, Gene Kim, Hans-Jurgen Gutke, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Laurence Barker, Michael Wolf
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Publication number: 20060099660
    Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
    Type: Application
    Filed: February 14, 2003
    Publication date: May 11, 2006
    Applicant: Synovo GMBH
    Inventors: Michael Burnet, Jan-Hinrich Guse, Gene Kim, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Laurence Barker, Michael Wolff
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Publication number: 20040087517
    Abstract: This invention features a compound of the following formula:
    Type: Application
    Filed: February 14, 2003
    Publication date: May 6, 2004
    Inventors: Michael Burnet, Jan-Hinrich Guse, Hans-Jurgen Gutke, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Jeannette Reichert, Kattie Luyten, Maximilian Busch, Michael Wolff, Moussa Khobzaoui, Simona Margutti, Thomas Meindl, Gene Kim, Laurence Barker
  • Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
    Publication number: 20040005641
    Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
    Type: Application
    Filed: February 14, 2003
    Publication date: January 8, 2004
    Inventors: Michael Burnet, Jan-Hinrich Guse, Gene Kim, Hans-Jurgen Gutke, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Laurence Barker, Michael Wolff
  • Process for the genetic modification of a plant
    Publication number: 20030163846
    Abstract: The invention relates to nucleic acid molecules that code a saccharide transporter, in particular a saccharose transporter, vectors and host cells that contain said nucleic acid molecules, as well as plant cells and plants transformed by the described nucleic acid molecules and vectors. The invention also relates to processes for modifying the transport of saccharide, in particular saccharose, in plants.
    Type: Application
    Filed: September 18, 2002
    Publication date: August 28, 2003
    Inventors: John M. Ward, Andreas Weise, Laurence Barker, Wolf-Bernd Frommer, Waltraud Schulze, Christina Kuhn