Patents by Inventor Laurence Danober

Laurence Danober has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8569285
    Abstract: Compounds of formula (I): wherein R1 represents a hydrogen atom or a heterocyclic, cyano, alkoxycarbonyl, alkylsulphonylaminoalkyl or N-hydroxycarboximidamide group. Medicinal products containing the same which are useful as modulators of the AMPA receptor.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: October 29, 2013
    Assignee: Les Laboratoires Servier
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Patent number: 8236790
    Abstract: Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: August 7, 2012
    Assignee: Les Laboratories Servier
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Publication number: 20120071462
    Abstract: Compounds of formula (I): wherein R1 represents a hydrogen atom or a heterocyclic, cyano, alkoxycarbonyl, alkylsulphonylaminoalkyl or N-hydroxycarboximidamide group. Medicinal products containing the same which are useful as modulators of the AMPA receptor.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 22, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Publication number: 20100240635
    Abstract: Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 23, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Patent number: 7741320
    Abstract: Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group, R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: June 22, 2010
    Assignee: Les Laboratoires Servier
    Inventors: Pierre Francotte, Pascal De Tullio, Bernard Pirotte, Laurence Danober, Pierre Lestage, Daniel-Henri Caignard
  • Publication number: 20100009974
    Abstract: Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group, R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
    Type: Application
    Filed: July 9, 2009
    Publication date: January 14, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Pierre FRANCOTTE, Pascal De Tullio, Bernard Pirotte, Laurence Danober, Pierre Lestage, Daniel-Henri Caignard
  • Patent number: 7476668
    Abstract: Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR? and SO2NHR? wherein R? represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: January 13, 2009
    Assignee: Les Laboratoires Servier
    Inventors: Emmanuel Graindorge, Pierre Francotte, Stéphane Boverie, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Pierre Renard, Daniel-Henri Caignard
  • Patent number: 7268129
    Abstract: Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group selected from alkylaminocarbonyl and optionally substituted alkyl, R2 represents hydrogen, halogen or a group selected from cycloalkyl and optionally substituted alkyl, R3 to R6, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, nitro, cyano, alkylsulphonyl, hydroxy, alkoxy, optionally substituted alkyl and optionally substituted amino, its optical isomers when they exist, and also their addition salts with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as AMPA modulators.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: September 11, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Pierre Francotte, Pierre Fraikin, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 7262190
    Abstract: The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A represents CR3R4 or NR3 wherein R3 and R4 are as defined in the description, Y represents an alkylene chain as described in the description, X represents NR5R6, S(O)nR7, OR8, C(O)R9, amidino or a heterocycle, their isomers, and addition salts thereof; and medicinal products containing the same which are useful in the prevention or treatment of diseases associated with AMPA flux.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: August 28, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage, Laurence Danober
  • Publication number: 20070004709
    Abstract: Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR? and SO2NHR? wherein R? represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.
    Type: Application
    Filed: May 4, 2004
    Publication date: January 4, 2007
    Inventors: Pierre Francotte, Stephane Boverie, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Pierre Renard, Daniel-Henri Caignard
  • Publication number: 20060128697
    Abstract: The invention relates to compounds of formula (I): wherein R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A represents CR3R4 or NR3 wherein R3 and R4 are as defined in the description, Y represents an alkylene chain as described in the description, X represents NR5R6, S(O)nR7, OR8, C(O)R9, amidino or a heterocycle, their isomers, and addition salts thereof; and medicinal products containing the same which are useful in the prevention or treatment of diseases associated with AMPA flux.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 15, 2006
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage, Laurence Danober
  • Publication number: 20060019995
    Abstract: A compound selected from those of formula (I): wherein: R1 represents hydrogen, aryl(C1-C6)alkyl, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, aryl(C1-C6)alkoxycarbonyl, or trifluoroacetyl, R2 represents hydrogen, linear or branched (C1-C6)alkyl, X represents oxygen or NOR3, R3 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more identical or different groups selected from hydroxy, amino and linear or branched (C1-C6)alkoxy, Ar represents aryl or heteroaryl, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cognitive disorders and which possess antalgic properties.
    Type: Application
    Filed: November 4, 2003
    Publication date: January 26, 2006
    Inventors: Sylvain Rault, Nicolas Leflemme, Patrick Dallemagne, Pierre Lestage, Brian Lockhart, Laurence Danober, Bruno Pfeiffer, Pierre Renard
  • Publication number: 20050165008
    Abstract: Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group selected from alkylaminocarbonyl and optionally substituted alkyl, R2 represents hydrogen, halogen or a group selected from cycloalkyl and optionally substituted alkyl, R3 to R6, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, nitro, cyano, alkylsulphonyl, hydroxy, alkoxy, optionally substituted alkyl and optionally substituted amino, its optical isomers when they exist, and also their addition salts with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as AMPA modulators.
    Type: Application
    Filed: January 24, 2005
    Publication date: July 28, 2005
    Inventors: Pierre Francotte, Pierre Fraikin, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Daniel-Henri Caignard, Pierre Renard