Patents by Inventor Laurence David Sibley

Laurence David Sibley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIGENS FOR DETECTING TOXOPLASMA INFECTION BY MONITORING CELLULAR IMMUNITY
    Publication number: 20240091327
    Abstract: Antigens of Toxoplasma gondii that provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-? secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-? secretion may be used.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Inventors: Laurence David Sibley, Kevin M. Brown, Qiuling Wang, Iti Saraav
  • IMMUNOLOGICALLY ACTIVE FRAGMENTS OF TOXOPLASMA GONDII
    Publication number: 20220288174
    Abstract: T. gondii proteins MIC1 and MIC4 are components of excretory/secretory antigens (ESA) that elicit delayed type hypersensitivity (DTH) responses in infected animals. These antigens are capable of inducing IFN-g secretion by splenic T cells (ELISPOT assay), stimulating T cells to produce cytokines that recruit inflammatory monocytes and neutrophils resulting in a positive luminol test (luminol ear assay), and eliciting a positive skin test in the guinea pig.
    Type: Application
    Filed: August 19, 2020
    Publication date: September 15, 2022
    Inventors: LAURENCE DAVID SIBLEY, ITI SARAAV, QIULING WANG, MARY SAVARI DHASON
  • ANTIGENS FOR DETECTING TOXOPLASMA INFECTION BY MONITORING CELLULAR IMMUNITY
    Publication number: 20220265789
    Abstract: Antigens of Toxoplasma gondii that provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-? secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-? secretion may be used.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 25, 2022
    Inventors: Laurence David Sibley, Kevin M. Brown, Qiuling Wang, Iti Saraav
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF PARASITIC DISEASES
    Publication number: 20220193034
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.
    Type: Application
    Filed: April 22, 2020
    Publication date: June 23, 2022
    Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Laurence David Sibley, Bruno Melillo, Eamon Comer
  • Antigens for detecting toxoplasma infection by monitoring cellular immunity
    Patent number: 11351233
    Abstract: Antigens of Toxoplasma gondii that provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-y secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-y secretion may be used.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 7, 2022
    Assignee: Washington University
    Inventors: Laurence David Sibley, Kevin M. Brown, Qiuling Wang, Iti Saraav
  • Compositions and methods for treating parasitic diseases
    Patent number: 11208411
    Abstract: Disclosed herein, inter alia, are compositions and methods for treating parasitic diseases.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 28, 2021
    Assignees: The Regents of the University of California, Washington University
    Inventors: Florentine Rutaganira, Kevan M. Shokat, Laurence David Sibley, James W. Janetka
  • COMPOSITIONS AND METHODS FOR TREATING PARASITIC DISEASES
    Publication number: 20200291030
    Abstract: Disclosed herein, inter alia, are compositions and methods for treating parasitic diseases.
    Type: Application
    Filed: March 17, 2017
    Publication date: September 17, 2020
    Inventors: Florentine Rutaganira, Kevan M. Shokat, Laurence David Sibley, James W. Janetka
  • ANTIGENS FOR DETECTING TOXOPLASMA INFECTION BY MONITORING CELLULAR IMMUNITY
    Publication number: 20190275124
    Abstract: Antigens of Toxoplasma gondii that provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-y secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-y secretion may be used.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 12, 2019
    Inventors: Laurence David Sibley, Kevin M. Brown, Qiuling Wang, Iti Saraav