Patents by Inventor Laurence G. Rahme

Laurence G. Rahme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthranilyl-adenosinemonosulfamate analogs and uses thereof
    Patent number: 10874686
    Abstract: Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or of an infectious disease (e.g., bacterial infection (e.g., P. aeruginosa infection).
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: December 29, 2020
    Assignees: Memorial Sloan-Kettering Cancer Center, The General Hospital Corporation, East Carolina University
    Inventors: Derek Shieh Tan, Cheng Ji, Indrajeet Sharma, Debarshi Pratihar, James P. Coleman, Everett C. Pesci, Laurence G. Rahme
  • ANTHRANILYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF
    Publication number: 20190038656
    Abstract: Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or of an infectious disease (e.g., bacterial infection (e.g., P. aeruginosa infection).
    Type: Application
    Filed: October 3, 2016
    Publication date: February 7, 2019
    Applicants: Memorial Slooan-Kettering Cancer Center, The General Hospital Corporation d/b/a Massachusetts General Hospital, East Carolina University
    Inventors: Derek Shieh Tan, Cheng Ji, Indrajeet Sharma, Debarshi Pratihar, James P. Coleman, Everett C. Pesci, Laurence G. Rahme
  • METHODS FOR THE PREVENTION OR TREATMENT OF BACTERIAL AND FUNGAL INFECTIONS
    Publication number: 20100184804
    Abstract: The present invention features improved methods for treating, stabilizing, or preventing a bacterial or a fungal infection in a plant or an animal, such as a mammal. In particular, these methods involve the use of a compound, that is controlled by MvfR, and that affects the expression of an MvfR protein or that promotes its modification or inactivation, or a compound produced by P. aeruginosa strain PA14, but not by P. aeruginosa containing an mvfR mutation, in late stationary phase cultures.
    Type: Application
    Filed: November 20, 2009
    Publication date: July 22, 2010
    Inventors: Laurence G. Rahme, Hui Cao, Francois Lepine, Eric Deziel, Ronald G. Tompkins
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Patent number: 7166270
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: January 23, 2007
    Assignees: The Netherlands Cancer Institute, The General Hospital Corporation
    Inventors: Frederick M. Ausubel, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun, Shalina Mahajan-Miklos, Annegien Broeks, Ronald H. A. Plasterk, Georg Jander, Jacqueline Heard
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Patent number: 6905670
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: June 14, 2005
    Assignee: The General Hospital Corporation
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Eleftherios Mylonakis, Andrew Diener, Julia Plotnikova, Costi D. Sifri, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun, Georg Jander, Jacqueline Heard
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Publication number: 20030086871
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.
    Type: Application
    Filed: May 22, 2002
    Publication date: May 8, 2003
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Eleftherios Mylonakis, Andrew Diener, Julia Plotnikova, Costi D. Sifri, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun, Georg Jander, Jacqueline Heard
  • Virulence-associated nucleic acid sequences and uses thereof
    Publication number: 20030022349
    Abstract: Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.
    Type: Application
    Filed: October 10, 2001
    Publication date: January 30, 2003
    Inventors: Frederick M. Ausubel, Laurence G. Rahme
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Patent number: 6461854
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: October 8, 2002
    Assignee: The General Hospital Corporation
    Inventors: Frederick M. Ausubel, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun
  • Virulence-associated nucleic acid sequences and uses thereof
    Patent number: 6355411
    Abstract: Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 12, 2002
    Assignee: The General Hospital Corporation
    Inventors: Frederick Ausubel, Howard M. Goodman, Laurence G. Rahme, Shalina Mahajan-Miklos, Man-Wah Tan, Hui Cao, Eliana Drenkard, John Tsongalis