Abstract: An implantable medical device comprising (a) a metallic substrate and (b) a bisphosphonate wherein both phosphorus atoms contained in the bisphosphonate are covalently attached to a same carbon atom. The bisphosphonate continuously coats the external surface of the metallic substrate as monolayer and as outermost layer. At least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate and/or covalently bonded to another molecule of the bisphosphonate in the coating.

Abstract: An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen, (b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft.

Abstract: An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen, (b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft.

Abstract: An implantable medical device comprising (a) a metallic substrate and (b) a bisphosphonate wherein both phosphorus atoms contained in the bisphosphonate are covalently attached to a same carbon atom. The bisphosphonate continuously coats the external surface of the metallic substrate as monolayer and as outermost layer. At least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate and/or covalently bonded to another molecule of the bisphosphonate in the coating.