Abstract: Methods for classifying subjects and analyzing the relation between subject classification and multiple features of the subjects are provided. Some embodiments of the disclosure provide processes that use clustering analysis as an unsupervised machine learning technique to classify subjects based on multiple features. Some embodiments may associate features of the subjects with a categorical variable on which subject groups are based. This association between the features and the categorical variable of interest (or subject groups) can be obtained by finding featured-based clusters that have similar members as the subject groups. Systems and computer program products implementing the methods are also disclosed.

Abstract: Methods for classifying subjects and analyzing the relation between subject classification and multiple features of the subjects are provided. Some embodiments of the disclosure provide processes that use clustering analysis as an unsupervised machine learning technique to classify subjects based on multiple features. Some embodiments may associate features of the subjects with a categorical variable on which subject groups are based. This association between the features and the categorical variable of interest (or subject groups) can be obtained by finding featured-based clusters that have similar members as the subject groups. Systems and computer program products implementing the methods are also disclosed.

Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.

Abstract: The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.