Patents by Inventor Laurence I. Wu
Laurence I. Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11701377Abstract: A compound useful for treating leukemia or myelodysplastic syndrome, having the structure of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is H or —C(?O)—O—R3, and R2 is H or —C(?O)—O—R4, provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, and heteroalkyl. In an exemplary compound of formula (I), R1 is —C(?O)—O—CH2—CH3, and R2 is H.Type: GrantFiled: April 27, 2021Date of Patent: July 18, 2023Inventor: Laurence I. Wu
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Publication number: 20210244755Abstract: A compound useful for treating leukemia or myelodysplastic syndrome, having the structure of formula (I): or a pharmaceutically acceptable salt thereof, wherein R is H or —C(?O)—O—R3, and R2 is H or —C(?O)—O—R4, provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, and heteroalkyl. In an exemplary compound of formula (I), R1 is —C(?O)—O—CH2—CH3, and R2 is H.Type: ApplicationFiled: April 27, 2021Publication date: August 12, 2021Inventor: Laurence I. WU
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Patent number: 11021510Abstract: A compound useful for treating lymphoma, having the structure of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is H or —C(?O)—O—R3, and R2 is H or —C(?O)—O—R4, provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, and heteroalkyl. In an exemplary compound of formula (I), R1 is —C(?O)—O—CH2—CH3, and R2 is H.Type: GrantFiled: November 1, 2017Date of Patent: June 1, 2021Inventor: Laurence I. Wu
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Publication number: 20200095272Abstract: The present invention provides prodrugs of clofarabine. The compounds of the invention have formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is H or —C(=0)-X—R3 and R2 is H or —C(=0)-Y—R4, wherein X and Y are each independently O, CH2 or CH(NH2), provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compositions of formula (I) and methods for the treatment of cancer are also provided.Type: ApplicationFiled: November 1, 2017Publication date: March 26, 2020Inventor: Laurence I. WU
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Patent number: 9890189Abstract: The present invention provides compounds according to formula I: and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, —C(?O)—(CH2)2-aryl, and —C(?O)—(CH2)n—C(?O)—NH-aryl. The subscript n is from 2 to 6. R3 is selected from the group consisting of H and —C(?O)—O—R4; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R1 and R2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.Type: GrantFiled: December 5, 2016Date of Patent: February 13, 2018Assignee: BoYen Therapeutics, Inc.Inventor: Laurence I. Wu
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Publication number: 20170107245Abstract: The present invention provides compounds according to formula I: and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, —C(?O)—(CH2)2-aryl, and —C(?O)—(CH2)n—C(?O)—NH-aryl. The subscript n is from 2 to 6. R3 is selected from the group consisting of H and —C(?O)—O—R4; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R1 and R2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.Type: ApplicationFiled: December 5, 2016Publication date: April 20, 2017Applicant: BoYen Therapeutics, Inc.Inventor: Laurence I. Wu
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Patent number: 9540410Abstract: The present invention provides compounds according to formula I: and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, —C(?O)—(CH2)2-aryl, and —C(?O)—(CH2)n—C(?O)—NH-aryl. The subscript n is from 2 to 6. R3 is selected from the group consisting of H and —C(?O)—O—R4; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R1 and R2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.Type: GrantFiled: January 16, 2015Date of Patent: January 10, 2017Assignee: BOYEN THERAPEUTICS, INC.Inventor: Laurence I. Wu
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Publication number: 20150132298Abstract: The present invention provides compounds according to formula I: and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, —C(?O)—(CH2)2-aryl, and —C(?O)—(CH2)n—C(?O)—NH-aryl. The subscript n is from 2 to 6. R3 is selected from the group consisting of H and —C(?O)—O—R4; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R1 and R2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.Type: ApplicationFiled: January 16, 2015Publication date: May 14, 2015Inventor: Laurence I. Wu
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Patent number: 8956613Abstract: The present invention provides compounds according to formula I: and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, —C(?O)—(CH2)2-aryl, and —C(?O)—(CH2)n—C(?O)—NH-aryl. The subscript n is from 2 to 6. R3 is selected from the group consisting of H and —C(?O)—O—R4; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R1 and R2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.Type: GrantFiled: November 12, 2013Date of Patent: February 17, 2015Assignee: BoYen Therapeutics, Inc.Inventor: Laurence I. Wu
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Publication number: 20140134160Abstract: The present invention provides compounds according to formula I: and pharmaceutically acceptable salts thereof. For compounds of formula I, R1 and R2 are independently selected from the group consisting of H, —C(?O)—(CH2)2-aryl, and —C(?O)—(CH2)n—C(?O)—NH-aryl. The subscript n is from 2 to 6. R3 is selected from the group consisting of H and —C(?O)—O—R4; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R1 and R2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.Type: ApplicationFiled: November 12, 2013Publication date: May 15, 2014Applicant: BoYen Therapeutics, Inc.Inventor: Laurence I. Wu
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Patent number: 6900214Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.Type: GrantFiled: March 22, 2002Date of Patent: May 31, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Louis J. Lombardo, Laurence I. Wu
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Publication number: 20020143026Abstract: The present invention provides compounds of formula I 1Type: ApplicationFiled: March 22, 2002Publication date: October 3, 2002Inventors: Louis J. Lombardo, Laurence I. Wu
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Patent number: 5618835Abstract: A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.Type: GrantFiled: February 1, 1996Date of Patent: April 8, 1997Assignee: The Procter & Gamble CompanyInventors: Laurence I. Wu, John M. Janusz