Patents by Inventor Laurence M. Harwood

Laurence M. Harwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asymmetric synthesis of peptides
    Patent number: 8399612
    Abstract: A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemization, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerization.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: March 19, 2013
    Assignee: University of Reading
    Inventors: Laurence M. Harwood, Ran Yan
  • ASYMMETRIC SYNTHESIS OF PEPTIDES
    Publication number: 20120190816
    Abstract: The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC (O)— occurs without racemisation. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.
    Type: Application
    Filed: July 20, 2011
    Publication date: July 26, 2012
    Inventors: Laurence M. Harwood, Ran Yan
  • ASYMMETRIC SYNTHESIS OF PEPTIDES
    Publication number: 20110275784
    Abstract: The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC (O)— occurs without racemisation. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.
    Type: Application
    Filed: July 20, 2011
    Publication date: November 10, 2011
    Inventors: Laurence M. Harwood, Ran Yan
  • Asymmetric synthesis of peptides
    Patent number: 8044173
    Abstract: A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: October 25, 2011
    Assignee: University of Reading
    Inventors: Laurence M. Harwood, Ran Yan
  • ASYMMETRIC SYNTHESIS OF PEPTIDES
    Publication number: 20080281075
    Abstract: The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.
    Type: Application
    Filed: March 20, 2008
    Publication date: November 13, 2008
    Inventors: Laurence M. Harwood, Ran Yan