Abstract: This invention relates to connectors to be provided into fluid communication or engagement either directly with, or via a component to be associated with, a terminal end of a breathing conduit. In at least one embodiment, the connector comprises a body having a first end and a second end, and an internal lumen for the passage of gas between the ends. The first end engageable with a terminal end of a conduit or a component to be associated therewith. The second end engageable with another connector. An internal surface of the body at the second end comprises internal connection features for connection with another connector to be received internally therein. An external surface of the body comprises one or more external alignment feature(s) for aligning the connector or another connection into an aligned orientation for connection therebetween.

Abstract: TROP2 binders and variants thereof are described. In a specific embodiment, the TROP2 binders that are antibodies that preferentially bind high-expressing TROP2 cells over low-expressing TROP2 cells and conjugates thereof comprising the TROP2 binders conjugated to a payload are described.

Abstract: A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

Abstract: This invention relates to connectors to be provided into fluid communication or engagement either directly with, or via a component to be associated with, a terminal end of a breathing conduit. In at least one embodiment, the connector comprises a body having a first end and a second end, and an internal lumen for the passage of gas between the ends. The first end engageable with a terminal end of a conduit or a component to be associated therewith. The second end engageable with another connector. An internal surface of the body at the second end comprises internal connection features for connection with another connector to be received internally therein. An external surface of the body comprises one or more external alignment feature(s) for aligning the connector or another connection into an aligned orientation for connection therebetween.

Abstract: The present disclosure provides for a porous gas sorbent material with superior gravimetric working capacity and volumetric capacity, a gas storage system including a porous gas sorbent material of the present disclosure, methods of making the same, and method for storing a gas. The porous gas sorbent material includes a gas adsorbing material and a non-aqueous binder.

Abstract: Provided is a method for treating keratinous fibers comprising: applying steam to the keratinous fibers at a rate of less than 5 g/min; and shaping the keratinous fibers at a temperature of greater than 50° C., wherein the application of the steam and the shaping of the keratinous fibers do not occur simultaneously. The method disclosed herein may make it possible for example to obtain rapid shaping of the keratinous fibers while improving their cosmetic properties and the comfort of the user.

Abstract: Provided is a method for treating keratinous fibers comprising: applying steam to the keratinous fibers at a rate of less than 5 g/min; and shaping the keratinous fibers at a temperature of greater than 50° C., wherein the application of the steam and the shaping of the keratinous fibers do not occur simultaneously. The method disclosed herein may make it possible for example to obtain rapid shaping of the keratinous fibers while improving their cosmetic properties and the comfort of the user.

Abstract: The present invention relates to a cosmetic composition comprising: a) one or more amphoteric or zwitterionic surfactants, b) one or more cationic surfactants, c) one or more sulfureous reducing agents, and d) one or more alkaline agents, the weight ratio between the total amount of the amphoteric or zwitterionic surfactant(s), on the one hand, and the total amount of the cationic surfactant(s), on the other hand, being greater than or equal to 1.2. The present invention also relates to processes using this composition. The invention also relates to the use of the composition according to the invention for relaxing the curls and/or reducing the volume of keratin fibres, preferably the hair.

Abstract: The subject matter of the present invention is a method for straightening/relaxing the hair, which comprises (i) the application to the hair of a cosmetic composition comprising at least glyoxylic acid and/or at least one derivative thereof, the composition having a pH of less than or equal to 4, (ii) a leave on time for the composition comprising glyoxylic acid and/or at least one derivative thereof of at least 10 min, followed by (iii) the application, without rinsing, of a composition comprising at least one hair treatment compound chosen from fatty alcohols and cationic conditioning agents, and then by (iv) a heat application step comprising at least one step of heating at a temperature of at least 150° C. The method for straightening the hair according to the invention is effective in terms of straightening and quickly implemented.

Abstract: A system and method for layered application server processing. Embodiments of the system are particularly useful in extreme transaction processing (XTP) environments to support hundreds of thousands of simultaneous users, and perhaps millions of simultaneous transactions. Applications can be built from service components. Mashups can be performed on applications, services, and data, to create a more dynamic form of application. Data center consolidation and server virtualization techniques can be used to distribute applications over multiple machines or data centers. A horizontal Operating System (OS) fabric is then used to integrate components of the data centers in a dynamic fashion, including for example integrating portal or Service Component Architecture (SCA) components into personality profiles that can be federated over many (e.g. thousands) of Java machines and data centers.

Abstract: Process for treating keratin fibres using at least one sulfureous reducing agent, at least one cationic polymer and at least one mercaptosiloxane The present invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising a step of applying to the keratin fibres a reducing composition (A) comprising one or more sulfureous reducing agents, optionally a step of applying to the keratin fibres an oxidizing composition (B), a step of applying a rinse-out or leave-in care composition (C), comprising one or more cationic polymers and optionally one or more amino silicones (i), it being understood that the reducing composition (A) and/or the oxidizing composition (B) and/or composition (C) comprise(s) one or more silicones (ii), other than the silicones (i), with a molecular weight of less than 10 000 and functionalized with one or more mercapto groups.

Abstract: A method for estimating a combustion torque acting upon a crankshaft of an internal combustion engine is described. In one example, the method includes acquiring an instantaneous engine speed signal, calculating a cyclic engine speed signal based on the instantaneous engine speed signal, averaging the cyclic engine speed signal, correcting the averaged cyclic engine speed signal for engine losses, and estimating the combustion torque based on the corrected averaged cyclic engine speed signal. The description also concerns a control unit for an internal combustion engine.

Abstract: A pipe joining device for forming a junction in pressurised and rehabilitated pipes between a first pipe and a branch pipe, the pipe joining device including a substantially rigid body at least in part of thermoplastic, the body including a first pipe sealing portion adapted to form a seal with the first pipe and a branch pipe sealing portion adapted to form a seal with the branch pipe.

Abstract: A volatilizable substance can be sampled from a surface using a hand-held sampler employing a probe that comprises a supply tube in fluid communication with a pressurized gas supply and an outlet proximate to a target surface, a recovery tube having an inlet proximate to the target surface and being in fluid communication with a collector or analyzer and a skirt of varied depth. The probe is brought into contact with the surface, preferably in at least three points, gas flows out through the supply tube onto the surface, the volatilizable substance is volatilized, uptaken in to the gas and a fraction of the gas flows back through the recovery tube to the collector or analyzer, the remainder flowing under the skirt to prevent ingress of contaminants.

Abstract: Disclosed herein are cosmetic compositions comprising: at least one carboxylic anionic surfactant, and at least one vinylformamide/vinylformamine copolymer comprising from 10 to 90 mol % of units of formula A: and from 90 to 10 mol % of units of formula B: and processes for use thereof.

Abstract: The disclosure relates to novel detergent and conditioning compositions comprising, in a cosmetically acceptable aqueous medium, (A) at least one anionic surfactant comprising at least one group chosen from sulfate, sulfonate and phosphate, (B) at least one carboxylic anionic surfactant other than the at least one anionic surfactant of (A), (C) at least one amphoteric or zwitterionic surfactant, (D) at least one alkylpolyglycoside nonionic surfactant, (E) at least one cationic polymer with a cationic charge density of greater than or equal to 4 meq./g, and (F) at least one beneficial agent other than the at least one cationic polymer of (E), wherein the sulfate, sulfonate or phosphate anionic surfactant/amphoteric surfactant weight ratio is in a range from 0.1 to 2. Also disclosed are uses of said composition for cleansing and caring for the hair or the skin.

Abstract: Provided is a method for treating keratinous fibers comprising: applying steam to the keratinous fibers at a rate of less than 5 g/min; and shaping the keratinous fibers at a temperature of greater than 50° C., wherein the application of the steam and the shaping of the keratinous fibers do not occur simultaneously. The method disclosed herein may make it possible for example to obtain rapid shaping of the keratinous fibers while improving their cosmetic properties and the comfort of the user.

Abstract: A system and method for layered application server processing. Embodiments of the system are particularly useful in extreme transaction processing (XTP) environments to support hundreds of thousands of simultaneous users, and perhaps millions of simultaneous transactions. Applications can be built from service components. Mashups can be performed on applications, services, and data, to create a more dynamic form of application. Data center consolidation and server virtualization techniques can be used to distribute applications over multiple machines or data centers. A horizontal Operating System (OS) fabric is then used to integrate components of the data centers in a dynamic fashion, including for example integrating portal or Service Component Architecture (SCA) components into personality profiles that can be federated over many (e.g. thousands) of Java machines and data centers.

Abstract: The disclosure relates to novel detergent and conditioning compositions comprising, in a cosmetically acceptable aqueous medium, (A) at least one anionic surfactant comprising at least one group chosen from sulfate, sulfonate and phosphate, (B) at least one carboxylic anionic surfactant other than the at least one anionic surfactant of (A), (C) at least one amphoteric or zwitterionic surfactant, (D) at least one alkylpolyglycoside nonionic surfactant, (E) at least one cationic polymer with a cationic charge density of greater than or equal to 4 meq./g, and (F) at least one beneficial agent other than the at least one cationic polymer of (E), wherein the sulfate, sulfonate or phosphate anionic surfactant/amphoteric surfactant weight ratio is in a range from 0.1 to 2. Also disclosed are uses of said composition for cleansing and caring for the hair or the skin.