Patents by Inventor Laurence Prat

Laurence Prat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 8759583
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: June 24, 2014
    Assignee: Teva Sante
    Inventors: Laurent Courvoisier, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • Regioselective reduction of fused pyrrolocarbazoles-5,7-diones
    Patent number: 8410267
    Abstract: The present invention relates to a method for regioselectively reducing the maleimide compounds of formula (I). The invention also relates to C7 hydroxy lactam regioisomers of formula (II) obtainable by this method and their use for the preparation of lactams of formula (III) which are particularly useful as intermediate for the synthesis of fused pyrrolocarbazoles.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: April 2, 2013
    Assignee: Teva Sante
    Inventor: Laurence Prat-Lacondemine
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 8318979
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: November 27, 2012
    Assignee: Cephalon France
    Inventors: Laurent Courvoisier, Veronique Courvoisier, legal representative, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation
    Publication number: 20120123161
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Application
    Filed: March 24, 2011
    Publication date: May 17, 2012
    Applicant: CEPHALON FRANCE
    Inventors: Laurent Courvoisier, Veronique Courvoisier, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • REGIOSELECTIVE REDUCTION OF FUSED PYRROLOCARBAZOLES-5,7-DIONES
    Publication number: 20110224436
    Abstract: The present invention relates to a method for regioselectively reducing the maleimide compounds of formula (I). The invention also relates to C7 hydroxy lactam regioisomers of formula (II) obtainable by this method and their use for the preparation of lactams of formula (III) which are particularly useful as intermediate for the synthesis of fused pyrrolocarbazoles.
    Type: Application
    Filed: May 11, 2011
    Publication date: September 15, 2011
    Applicant: CEPHALON FRANCE
    Inventor: Laurence Prat-Lacondemine
  • Process for Enantioselective Synthesis of Single Enantiomers of Thio-Substituted Arylmethanesulfinyl Derivatives by Asymmetric Oxidation
    Publication number: 20110098505
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.
    Type: Application
    Filed: January 4, 2011
    Publication date: April 28, 2011
    Applicant: CEPHALON FRANCE
    Inventors: Laurence Prat, Olivier Neckebrock, Dominique Schweizer, Philippe Louvet
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 7915449
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: March 29, 2011
    Assignee: Cephalon France
    Inventors: François Rebiere, Gérard Duret, Laurence Prat
  • Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
    Patent number: 7893111
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: February 22, 2011
    Assignee: Cephalon France
    Inventors: Laurence Prat, Olivier Neckebrock
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 7812193
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I); wherein n, Y, R1, R1a, R2 and R2a are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 12, 2010
    Assignee: Cephalon France
    Inventors: Francois Rebiere, Gerard Duret, Laurence Prat
  • PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION
    Publication number: 20080214868
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined.
    Type: Application
    Filed: March 18, 2008
    Publication date: September 4, 2008
    Applicant: Cephalon France
    Inventors: Francois Rebiere, Gerard Duret, Laurence Prat, Guy Piacenza
  • Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation
    Publication number: 20080171896
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I); wherein n, Y, R1, R1a, R2 and R2a are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 17, 2008
    Applicant: Cephalon France
    Inventors: Francois Rebiere, Gerard Duret, Laurence Prat
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 7368591
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: May 6, 2008
    Assignee: Cephalon France
    Inventors: François Rebiere, Gérard Duret, Laurence Prat, Guy Piacenza
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 7317126
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I); wherein n, Y, R1, R1a, R2 and R2a are as defined herein.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: January 8, 2008
    Assignee: Cephalon France
    Inventors: François Rebiere, Gérard Duret, Laurence Prat
  • Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
    Publication number: 20060205706
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.
    Type: Application
    Filed: March 13, 2006
    Publication date: September 14, 2006
    Applicant: Cephalon France
    Inventors: Laurence Prat, Olivier Neckebrock, Dominique Schweizer, Philippe Louvet
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Publication number: 20050222257
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Application
    Filed: March 17, 2005
    Publication date: October 6, 2005
    Applicant: Cephalon, Inc.
    Inventors: Francois Rebiere, Gerard Duret, Laurence Prat, Guy Piacenza
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Publication number: 20050080256
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I); wherein n, Y, R1, R1a, R2 and R2a are as defined herein.
    Type: Application
    Filed: September 17, 2004
    Publication date: April 14, 2005
    Inventors: Francois Rebiere, Gerard Duret, Laurence Prat