Abstract: A pre-filled hypodermic syringe includes a retractable needle and detachable plunger shaft so the syringe can be selectively rendered inoperable. A liquid held within the syringe is held in place by a elastomeric stop that surrounds the discharging tip of the needle. When the syringe is to be used, the needle stop is removed and the plunger is advanced within the syringe barrel until the liquid is displaced through the needle. When the plunger contacts the base of the needle within the syringe barrel, the plunger becomes capable of being rotated. The rotation of the plunger connects the plunger to the needle and the needle can be retracted into the syringe barrel with the plunger. Once fully retracted, the needle cants and the plunger shaft can be destructively disconnected from the plunger, rendering the syringe inoperable.