Abstract: The invention relates to MnTBAP or Mn(III) substituted pyridylporphyrin (MnP) compounds selected among MnTE-2-pYP5+, MnTEHex-2-Pyp5+ and MnTnBuOE-2-Pyp5+ for use in treating sepsis and/or reversing sepsis-induced microglial cells alteration(s), and/or reversing associated long-term cognitive impairment in a subject diagnosed with sepsis or sepsis-associated encephalopathy (SAE), and/or treating long-term cognitive impairment in a subject suffering from sepsis or sepsis-associated encephalopathy (SAE).

Abstract: The invention relates to a method for the detection of the occurrence of initiation of replication events in genomic DNA in a eukaryotic cell, involving contacting said eukaryotic cell comprising said genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said DNA genome and detecting said first nucleotide probe hybridized to said DNA. Further detection of at least one RNA molecule can be achieved.

Abstract: The invention relates to a method for in vitro investigating mitochondrial replication dysfunction in a biological sample removed from a subject susceptible of suffering from physiological ageing or physiopathological conditions related to physiological ageing, or physiopathological ageing or associated symptoms or conditions, in particular premature ageing or accelerated ageing, or of a progeroid syndrome, such as Cockayne syndrome (CS), or neurodegenerative disorders or symptoms thereof, in which the levels of at least one species selected in the group of: POLG1 protein, POLG1 RNA, POLG2 protein, protease(s) which have POLG as a target, in particular serine protease(s) such as HTRA3 protein, HTRA2 protein and, HTRA3 RNA or HTRA2 RNA, or any combination of these species, are investigated.

Abstract: A method to model a subterranean formation of a field. The method includes obtaining a seismic volume comprising a plurality of seismic traces of the subterranean formation of the field, computing, based on the seismic volume, a seismically-derived value of a structural attribute representing a structural characteristic of the subterranean formation, computing, based on a structural model, a structurally-derived value of the structural attribute, the structural model comprising a plurality of structural layers of the of the subterranean formation, comparing the seismically-derived value and the structurally-derived value to generate a difference value representing a discrepancy of modeling the structural attribute at a corresponding location in the subterranean formation, and generating a seismic interpretation result based on the difference value and the corresponding location.

Abstract: The invention relates to a method for in vitro investigating mitochondrial replication dysfunction in a biological sample removed from a subject susceptible of suffering from physiological ageing or physiopathological conditions related to physiological ageing, or physiopathological ageing or associated symptoms or conditions, in particular premature ageing or accelerated ageing, or of a progeroid syndrome, such as Cockayne syndrome (CS), or neurodegenerative disorders or symptoms thereof, in which the levels of at least one species selected in the group of: POLG1 protein, POLG1 RNA, POLG2 protein, protease(s) which have POLG as a target, in particular serine protease(s) such as HTRA3 protein, HTRA2 protein and, HTRA3 RNA or HTRA2 RNA, or any combination of these species, are investigated.

Abstract: The invention relates to a method for the detection of the occurrence of initiation of replication events in genomic DNA in a eukaryotic cell, involving contacting said eukaryotic cell comprising said genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said DNA genome and detecting said first nucleotide probe hybridized to said DNA. Further detection of at least one RNA molecule can be achieved.

Abstract: The invention relates to a method for in vitro investigating mitochondrial replication dysfunction in a biological sample removed from a subject susceptible of suffering from physiological ageing or physiopathological conditions related to physiological ageing, or physiopathological ageing or associated symptoms or conditions, in particular premature ageing or accelerated ageing, or of a progeroid syndrome, such as Cockayne syndrome (CS), or neurodegenerative disorders or symptoms thereof, in which the levels of at least one species selected in the group of: POLG1 protein, POLG1 RNA, POLG2 protein, protease(s) which have POLG as a target, in particular serine protease(s) such as HTRA3 protein, HTRA2 protein and, HTRA3 RNA or HTRA2 RNA, or any combination of these species, are investigated.

Abstract: The invention relates to a method for the detection of the occurrence of initiation of replication events in genomic DNA in a eukaryotic cell, involving contacting said eukaryotic cell comprising said genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said DNA genome and detecting said first nucleotide probe hybridized to said DNA. Further detection of at least one RNA molecule can be achieved.

Abstract: A method to model a subterranean formation of a field. The method includes obtaining a seismic volume comprising a plurality of seismic traces of the subterranean formation of the field, computing, based on the seismic volume, a seismically-derived value of a structural attribute representing a structural characteristic of the subterranean formation, computing, based on a structural model, a structurally-derived value of the structural attribute, the structural model comprising a plurality of structural layers of the of the subterranean formation, comparing the seismically-derived value and the structurally-derived value to generate a difference value representing a discrepancy of modeling the structural attribute at a corresponding location in the subterranean formation, and generating a seismic interpretation result based on the difference value and the corresponding location.

Abstract: The invention relates to a method for in vitro investigating mitochondrial replication dysfunction in a biological sample removed from a subject susceptible of suffering from physiological ageing or physiopathological conditions related to physiological ageing, or physiopathological ageing or associated symptoms or conditions, in particular premature ageing or accelerated ageing, or of a progeroid syndrome, such as Cockayne syndrome (CS), or neurodegenerative disorders or symptoms thereof, in which the levels of at least one species selected in the group of: POLG1 protein, POLG1 RNA, POLG2 protein, protease(s) which have POLG as a target, in particular serine protease(s) such as HTRA3 protein, HTRA2 protein and, HTRA3 RNA or HTRA2 RNA, or any combination of these species, are investigated.

Abstract: An evanescent wave microspectrometer includes a planar diopter separating two transparent media, an optical sensor with a pixel array, and disposed in the second transparent medium, and an interference device disposed such that at least a part of the interference device is in contact with evanescent waves generated at the surface of the diopter. The micro-spectrometer also includes a memory storing a map having a set of set of data grids including the optical response of said sensor for a set of quasi-monochromatic wavelengths of a calibration light source, and a calculator configured to determine the spectrum (?) of a test light source configured to generate evanescent waves at the surface of the diopter, on the basis of the map and the optical response of the sensor.

Abstract: An evanescent wave microspectrometer includes a planar diopter separating two transparent media, an optical sensor with a pixel array, and disposed in the second transparent medium, and an interference device disposed such that at least a part of the interference device is in contact with evanescent waves generated at the surface of the diopter. The micro-spectrometer also includes a memory storing a map having a set of set of data grids including the optical response of said sensor for a set of quasi-monochromatic wavelengths of a calibration light source, and a calculator configured to determine the spectrum (?) of a test light source configured to generate evanescent waves at the surface of the diopter, on the basis of the map and the optical response of the sensor.

Abstract: A method can include providing a mesh of a geologic environment that includes conformable sequences and an unconformity; interpolating an implicit function defined with respect to the mesh to provide values for the implicit function; and identifying an iso-surface based on a portion of the values where the iso-surface represents the unconformity as residing between two of the conformable sequences. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: A method, apparatus, and program product may utilize a stratigraphic implicit function, e.g., as used in connection with volume based modeling, to generate structural information for a subsurface formation. In particular, structural information for a subsurface formation may be generated by determining a location in a volume of interest in the subsurface formation from subsurface formation data associated with the subsurface formation, accessing a numerical model having a monotonously varying stratigraphic implicit function defined within the volume of interest to determine a value of the stratigraphic implicit function corresponding to the determined location, and generating at least one structural element for the subsurface formation from the stratigraphic implicit function of the numerical model based upon a spatial distribution of the determined value within the volume of interest.

Abstract: A method can include formulating a linear system of equations for an implicit function with respect to a mesh that represents a geologic environment; solving the linear system of equations as a first sub-system subject to at least one second order smoothness constraint and at least a portion of data and as a second sub-system subject to at least one first order smoothness constraint and at least a portion of the data; and, based at least in part on the solving, outputting values for the implicit function with respect to at least a portion of the mesh. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: The invention relates to a method for the detection of the occurrence of initiation of replication events in genomic DNA in a eukaryotic cell, involving contacting said eukaryotic cell comprising said genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said DNA genome and detecting said first nucleotide probe hybridized to said DNA. Further detection of at least one RNA molecule can be achieved.

Abstract: A method can include providing a mesh of a geologic environment that includes conformable sequences and an unconformity; interpolating an implicit function defined with respect to the mesh to provide values for the implicit function; and identifying an iso-surface based on a portion of the values where the iso-surface represents the unconformity as residing between two of the conformable sequences. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: A method of representing and using fractures in a model of a subterranean reservoir is described including the partitioning the fracture network into a discretely modeled part and a remaining statistically described part from a statistical description of all fractures, the determination of the correlation effects caused by fractures with dimensions exceeding dimension of the local grid cells and the determination of petrophysical properties while allowing for arbitrary distribution of fracture orientations, with all three aspects being combinable to improve the modeling of fractures and the simulation of fractured reservoirs.

Abstract: A method of representing and using fractures in a model of a subterranean reservoir is described including the partitioning the fracture network into a discretely modeled part and a remaining statistically described part from a statistical description of all fractures, the determination of the correlation effects caused by fractures with dimensions exceeding dimension of the local grid cells and the determination of petrophysical properties while allowing for arbitrary distribution of fracture orientations, with all three aspects being combinable to improve the modeling of fractures and the simulation of fractured reservoirs.

Abstract: A method can include providing a mesh of a geologic environment that includes conformable sequences and an unconformity; interpolating an implicit function defined with respect to the mesh to provide values for the implicit function; and identifying an iso-surface based on a portion of the values where the iso-surface represents the unconformity as residing between two of the conformable sequences. Various other apparatuses, systems, methods, etc., are also disclosed.