Abstract: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, the present invention relates to sized Streptococcus pneumoniae serotype 6A capsular polysaccharides, in particular Streptococcus pneumoniae serotype 6A capsular polysaccharides having the average size (e.g. Mw) of the Streptococcus pneumoniae serotype 6A capsular polysaccharide is between 100-1000 kDa, suitably conjugated to a carrier protein.

Abstract: A counter-rotating turbine for a turbine engine comprising an inner rotor having an inner drum to which is attached a plurality of inner impellers rotatably supported by a first shaft, an outer rotor comprising an outer drum to which is fastened a plurality of outer impellers rotatably supported by a second shaft coaxial with the first shaft, the outer rotor comprising a downstream impeller having a plurality of downstream moving blades extending between an outer shroud and an inner shroud, one upstream end of the outer shroud being attached downstream of said outer drum, the inner shroud being attached to the second shaft, at least one of the inner shroud and of the outer shroud comprising at least one flexible transition part configured to allow elastic deformation of said shroud in the radial direction.

Abstract: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, the present invention relates to sized Streptococcus pneumoniae serotype 6A capsular polysaccharides, in particular Streptococcus pneumoniae serotype 6A capsular polysaccharides having the average size (e.g. Mw) of the Streptococcus pneumoniae serotype 6A capsular polysaccharide is between 100-1000 kDa, suitably conjugated to a carrier protein.

Abstract: The present invention relates to a process for preparing immunogenic compositions. More particularly, it relates to a process for preparing liquid compositions of Protein D polypeptide and their use in preparing immunogenic compositions comprising Protein D polypeptide which may be used in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.

Abstract: The present invention relates to thermotropic ionic liquid crystal molecules of general formula (I) With E1 and E2, which may be identical or different, representing, independently of one another, a linear, saturated and unsubstituted C10 to C14 hydrocarbon-based radical, Ax? representing a sulfonate anion or a sulfonylimide anion of formula —SO2—N?—SO2CyF2y+1 with y being an integer ranging from 0 to 2 and Cx+ a sodium, lithium or potassium ion, most particularly advantageous for their conductivity performance qualities as an electrolyte in particular for lithium batteries.

Abstract: A method and a system are disclosed for making an article of manufacture from a blank defining an internal opening. A stack of blanks are aligned and the internal openings of the blanks in the stack of blanks are machined by a rotary cutting tool to a finished dimension. The blanks are clamped together before machining in a numerically controlled machine tool. The blanks are subsequently formed individually in a sheet metal forming operation in which the inner perimeter of the internal openings is expanded as the blank is formed.

Abstract: The present invention relates to a process for preparing immunogenic compositions. More particularly, it relates to a process for preparing liquid compositions of Protein D polypeptide and their use in preparing immunogenic compositions comprising Protein D polypeptide which may be used in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.

Abstract: The present invention provides attenuated, aroA mutant B. bronchiseptica strains that are effective to elicit an immune response in an animal against B. bronchiseptica. Also provided are immunogenic compositions and vaccines which include the attenuated, aroA mutant B. bronchiseptica strains. Also provided are kits for use with such compositions and vaccines. Also provided are methods of orally administering attenuated, aroA mutant B. bronchiseptica strains, compositions, and vaccines to animals.

Abstract: The present invention relates broadly to microfluidic devices, particularly microfluidic devices optimised for the industrial production of nanoparticles such as liposomes. The device (101) comprises a substrate which extends between a distal end (107) comprising an outlet region (105) and a proximal end (108) comprising an inlet region (106). The inlet region comprises two substantially parallel outer channels (103a, 103b) for transport of a first fluid, said outer channels (103a, 103b) defined in part by a first outer wall (109a) and a second outer wall (109b) respectively, and a linear inner channel (104) for transport of a second fluid. The linear channel is disposed between the two substantially parallel outer channels. The outer channels (103a, 103b) and inner channel (104) extend from the proximal end (108) to a mixing chamber (102) which extends from the inlet region (106) to the outlet region (105).

Abstract: Nanoparticles encapsulating polysaccharide conjugates and compositions comprising same are provided. Particularly the nanoparticles are prepared using a microfluidic device.

Abstract: Methods for manufacturing a non-viral delivery system comprising a liposome encapsulating an RNA using a microfluidic device and compositions for use therein are provided.

Abstract: The present invention relates to thermotropic ionic liquid crystal molecules of general formula (I) With E1 and E2, which may be identical or different, representing, independently of one another, a linear, saturated and unsubstituted C10 to C14 hydrocarbon-based radical, Ax? representing a sulfonate anion or a sulfonylimide anion of formula —SO2—N?—SO2CyF2y+1 with y being an integer ranging from 0 to 2 and Cx+ a sodium, lithium or potassium ion, most particularly advantageous for their conductivity performance qualities as an electrolyte in particular for lithium batteries.

Abstract: The invention relates to an annular combustion chamber in a turbine engine, comprising two coaxial walls of revolution, one an internal wall (12) and the other an external wall (14), between which emerge fuel injectors (19) each engaged in centring means (36) which are moveable in the radial direction in support means (38), the chamber also comprising means (50, 68) of axial retention in the upstream direction of the centring means. According to the invention, the means of axial retention in the upstream direction are removably fixed to at least one of the internal (12) or external (14) walls of revolution.

Abstract: The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to pH such that above a threshold pH level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.

Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.

Abstract: A method and a system are disclosed for making an article of manufacture from a blank defining an internal opening. A stack of blanks are aligned and the internal openings of the blanks in the stack of blanks are machined by a rotary cutting tool to a finished dimension. The blanks are clamped together before machining in a numerically controlled machine tool. The blanks are subsequently formed individually in a sheet metal forming operation in which the inner perimeter of the internal openings is expanded as the blank is formed.

Abstract: The invention relates to a device for supporting and centring a fuel injector in a turbine engine combustion chamber, which includes means for centring a fuel injector along an axis, which are movable in a plane that is radial to the centring axis (52) in supporting means intended for being attached to the bottom of an annular chamber (18). According to the invention, the centring means include at least two radially external tabs (54, 56) each inserted respectively in a circumferential recess (60, 64) of the supporting means, the device including circumferential abutment means (78, 80, 74, 76, 82, 86, 84, 88) of the radial tabs (54, 56) of the centring means in the circumferential recesses (60, 64), the circumferential abutment means being configured such as to enable a greater angular displacement of a first (54, 154) one of the radial tabs in a first circumferential recess (60) relative to a second (56, 156) one of the radial tabs in a second circumferential recess (64).

Abstract: A method and a system are disclosed for making an article of manufacture from a blank defining an internal opening. A stack of blanks are aligned and the internal openings of the blanks in the stack of blanks are machined by a rotary cutting tool to a finished dimension. The blanks are clamped together before machining in a numerically controlled machine tool. The blanks are subsequently formed individually in a sheet metal forming operation in which the inner perimeter of the internal openings is expanded as the blank is formed.

Abstract: A measuring comb for temperature and/or pressure and/or chemical composition of the gases flowing at the outlet of a turbine engine flow path, in which the flow path extends around an axis of revolution of the flow path, is provided. The measuring comb includes: a comb body with an elongated shape, intended to face the outlet of the flow path, the comb body including at least one measuring opening arranged along an axis, the measuring opening being configured to tap gases flowing at the outlet of the flow path; and an adjusting system configured to adjust an angle between the axis of the at least one measuring opening and the axis of revolution, so as to allow orientation of the at least one measuring opening in the flow direction of the gases at the outlet of the flow path.

Abstract: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, the present invention relates to sized Streptococcus pneumoniae serotype 6A capsular polysaccharides, in particular Streptococcus pneumoniae serotype 6A capsular polysaccharides having the average size (e.g. Mw) of the Streptococcus pneumoniae serotype 6A capsular polysaccharide is between 100-1000 kDa, suitably conjugated to a carrier protein.