Patents by Inventor Laurent Bernard Fischer

Laurent Bernard Fischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated Bordetella Bronchiseptica Strains, Oral Vaccines Containing the Attenuated Strains, and Methods of Making & Use Thereof
    Publication number: 20220054616
    Abstract: The present invention provides attenuated, aroA mutant B. bronchiseptica strains that are effective to elicit an immune response in an animal against B. bronchiseptica. Also provided are immunogenic compositions and vaccines which include the attenuated, aroA mutant B. bronchiseptica strains. Also provided are kits for use with such compositions and vaccines. Also provided are methods of orally administering attenuated, aroA mutant B. bronchiseptica strains, compositions, and vaccines to animals.
    Type: Application
    Filed: January 6, 2020
    Publication date: February 24, 2022
    Inventors: Laurent Bernard FISCHER, Edmond JOLIVET, Kevin MILLSAP
  • Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure
    Patent number: 10364274
    Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 30, 2019
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEATLH USA INC.
    Inventors: Laurent Bernard Fischer, Nicolas Pierre Yves Carboulec, Fabien Lux
  • Her2 DNA vaccine as adjunct treatment for cancers in companion animals
    Patent number: 9901628
    Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: February 27, 2018
    Assignee: MERIAL INC.
    Inventor: Laurent Bernard Fischer
  • EXPRESSION OF CHIMERIC KSAC PROTEIN AND METHOD OF PRODUCING SOLUBLE PROTEINS BY HIGH PRESSURE
    Publication number: 20170081372
    Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
    Type: Application
    Filed: February 5, 2016
    Publication date: March 23, 2017
    Applicant: MERIAL INC.
    Inventors: Laurent Bernard Fischer, Nicolas Pierre Yves Carboulec, Fabien Lux
  • Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure
    Patent number: 9315553
    Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: April 19, 2016
    Assignee: MERIAL, INC.
    Inventors: Laurent Bernard Fischer, Nicolas Pierre Yves Carboulec, Fabien Lux
  • Her2 DNA Vaccine as Adjunct Treatment for Cancers in Companion Animals
    Publication number: 20150374808
    Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.
    Type: Application
    Filed: April 29, 2015
    Publication date: December 31, 2015
    Applicant: MERIAL INC.
    Inventor: Laurent Bernard Fischer
  • Her2 DNA vaccine as adjunct treatment for cancers in companion animals
    Patent number: 9040053
    Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: May 26, 2015
    Assignee: MERIAL, INC.
    Inventor: Laurent Bernard Fischer
  • Canine leishmania vaccine
    Patent number: 8871225
    Abstract: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: October 28, 2014
    Assignee: Merial Limited
    Inventor: Laurent Bernard Fischer
  • EXPRESSION OF CHIMERIC KSAC PROTEIN AND METHOD OF PRODUCING SOLUBLE PROTEINS BY HIGH PRESSURE
    Publication number: 20140072594
    Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
    Type: Application
    Filed: August 30, 2013
    Publication date: March 13, 2014
    Applicant: MERIAL LIMITED
    Inventors: Laurent Bernard Fischer, Nicolas Pierre Yves Carboulec, Fabien Lux
  • vaccine using sand fly salivary immunogen
    Patent number: 8603808
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: December 10, 2013
    Assignees: Merial Limited, The United States of America As Represented by The Secretary of the Department of Health and Human Services
    Inventors: Laurent Bernard Fischer, Jesus G. Valenzuela, Jose Ribeiro, Shaden Kamhawi
  • Leishmania challenge model
    Patent number: 8414882
    Abstract: The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are naïve to Leishmania, infecting the canines using bites of Leishmania-infected sand fly bites, and evaluating successful transmission of the Leishmania parasites.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: April 9, 2013
    Assignee: Merial Limited
    Inventors: Laurent Bernard Fischer, Shaden Kamahwi, Jesus Valenzuela, Hamide Aslan Suau
  • Leishmania Challenge Model
    Publication number: 20120164179
    Abstract: The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are naïve to Leishmania, infecting the canines using bites of Leishmania-infected sand fly bites, and evaluating successful transmission of the Leishmania parasites.
    Type: Application
    Filed: November 15, 2011
    Publication date: June 28, 2012
    Inventors: Laurent Bernard Fischer, Shaden Kamahwi, Jesus Valenzuela, Hamide Aslan Suau
  • Her2 DNA Vaccine as Adjunct Treatment for Cancers in Companion Animals
    Publication number: 20120093841
    Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.
    Type: Application
    Filed: October 13, 2011
    Publication date: April 19, 2012
    Inventor: Laurent Bernard Fischer
  • Plasmid encoding feline BMP-7
    Patent number: 8097599
    Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: January 17, 2012
    Assignee: Merial Limited
    Inventor: Laurent Bernard Fischer
  • CANINE LEISHMANIA VACCINE
    Publication number: 20100285066
    Abstract: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
    Type: Application
    Filed: July 20, 2010
    Publication date: November 11, 2010
    Inventor: Laurent Bernard Fischer
  • INTRA-VASCULAR KIDNEY GENE THERAPY WITH PLASMID ENCODING BMP-7
    Publication number: 20100261782
    Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
    Type: Application
    Filed: June 4, 2010
    Publication date: October 14, 2010
    Inventor: Laurent Bernard Fischer
  • Canine vaccine
    Patent number: 7794736
    Abstract: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: September 14, 2010
    Assignee: Merial Limited
    Inventor: Laurent Bernard Fischer
  • Plasmid encoding human BMP-7
    Patent number: 7771995
    Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: August 10, 2010
    Assignee: Merial Limited
    Inventor: Laurent Bernard Fischer
  • LEISHMANIA VACCINE USING SAND FLY SALIVARY IMMUNOGEN
    Publication number: 20090324649
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
    Type: Application
    Filed: May 6, 2009
    Publication date: December 31, 2009
    Inventors: Laurent Bernard Fischer, Jesus G. Valenzuela, Jose Ribeiro, Shaden Kamhawi
  • Intra-vascular kidney gene therapy with plasmid encoding BMP-7
    Publication number: 20080269150
    Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
    Type: Application
    Filed: May 16, 2007
    Publication date: October 30, 2008
    Inventor: Laurent Bernard Fischer