Patents by Inventor Laurent Brard

Laurent Brard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9220714
    Abstract: The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: December 29, 2015
    Assignees: Brown University, Women and Infants' Hospital Rhode Island
    Inventors: Giselle L. Saulnier Sholler, Narasimha Swamy, Stayan Kalkunte, Rakesh K. Singh, Laurent Brard, Kyu Kwang Kim
  • Patent number: 9024039
    Abstract: This invention relates to the design, synthesis and use of synthetic vitamin D and other steroidal analogs. It further relates to the therapeutic use of such analogs and their manufacture.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: May 5, 2015
    Assignee: Women & Infants' Hospital of Rhode Island
    Inventors: Laurent Brard, Satyan Kalkunte, Rakesh Kumar Singh
  • Publication number: 20140371193
    Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
    Type: Application
    Filed: September 4, 2014
    Publication date: December 18, 2014
    Applicants: LOUISIANA STATE UNIVERSITY, WOMEN & INFANTS' HOSPITAL
    Inventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
  • Publication number: 20130331383
    Abstract: The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
    Type: Application
    Filed: May 17, 2013
    Publication date: December 12, 2013
    Applicants: BROWN UNIVERSITY, WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND
    Inventors: Henna Swamy, Laurent Brard, Rakesh K. Singh, Satyan Kalkunte, Narasimha Swamy, Giselle L. Saulnier Sholler, Kyu Kwang Kim
  • Patent number: 8470815
    Abstract: The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: June 25, 2013
    Assignees: Brown University, Women and Infants' Hospital Rhode Island
    Inventors: Giselle L. Saulnier Sholler, Satyan Kalkunte, Rakesh K. Singh, Laurent Brard, Kyu Kwang Kim, Hena Swamy
  • Publication number: 20130023511
    Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
    Type: Application
    Filed: July 23, 2012
    Publication date: January 24, 2013
    Applicants: LOUISIANA STATE UNIVERSITY, WOMEN & INFANTS' HOSPITAL
    Inventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
  • Patent number: 8252780
    Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: August 28, 2012
    Assignees: Women & Infants' Hospital, Louisiana State University
    Inventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
  • Patent number: 8193180
    Abstract: This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.
    Type: Grant
    Filed: January 23, 2008
    Date of Patent: June 5, 2012
    Assignee: Women & Infants Hospital
    Inventors: Laurent Brard, Rakesh Kumar Singh, Kyu Kwang Kim, Giselle Saulnier-Sholler
  • Publication number: 20110288080
    Abstract: The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.
    Type: Application
    Filed: March 7, 2007
    Publication date: November 24, 2011
    Inventors: Giselle L Saulnier Sholler, Narasimha Swamy, Henna Swamy, Satyan Kalkunte, Rakesh K. Singh, Laurent Brard, Kyu Kwang Kim
  • Publication number: 20100273763
    Abstract: This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
    Type: Application
    Filed: November 30, 2007
    Publication date: October 28, 2010
    Applicants: Women & Infants Hospital, Louisiana State University
    Inventors: Laurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
  • Publication number: 20100179136
    Abstract: This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.
    Type: Application
    Filed: January 23, 2008
    Publication date: July 15, 2010
    Applicant: WOMEN & INFANTS HOSPITAL
    Inventors: Laurent Brard, Rakesh Kumar Singh, Kyu Wang Kim, Giselle Saulnier-Sholler
  • Publication number: 20090221529
    Abstract: This invention relates to the design, synthesis and use of synthetic vitamin D and other steroidal analogs. It further relates to the therapeutic use of such analogs and their manufacture.
    Type: Application
    Filed: December 12, 2006
    Publication date: September 3, 2009
    Applicant: Women's & Infants Hospital of Rhode Island
    Inventors: Laurent Brard, Satyan Kalkunde, Rakesh Kumar Singh
  • Patent number: 5312881
    Abstract: The synthesis, and use as catalysts of chiral organolanthanide complexes for polymerization of substituted acrylates are disclosed, having the structure [(C.sub.5 R'.sub.4-x R*.sub.x) A (C.sub.5 R".sub.4-y R'''.sub.y) M Q.sub.p ].sup.m, where x and y represent the number of unsubstituted locations on the cyclopentadienyl ring; R', R", R''', and R* represent substituted and unsubstituted alkyl groups having 1-30 carbon atoms and R* is a chiral ligand; A is a fragment containing a Group 13, 14, 15, or 16 element of the Periodic Table; M is a Group 3, 4, 5, or lanthanide metal of the Periodic Table; and Q is a hydrocarbyl radical, aryl, hydrogen, amide radical, or halogen radical, with 3.gtoreq.p.gtoreq.o; and m=o or +1.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: May 17, 1994
    Assignee: Northwestern University
    Inventors: Tobin J. Marks, Yoshihiro Yamamoto, Laurent Brard, Michael Giardello