Patents by Inventor Laurent Daeffler

Laurent Daeffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer
    Patent number: 10058591
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: August 28, 2018
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Zahari Raykov, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Methods of treating cancer using chemovirotherapy
    Patent number: 9664684
    Abstract: Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: May 30, 2017
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg, Universitaetsklinikum Heidelberg
    Inventors: Nathalia Giese, Jens Werner, Markus Buechler, Thomas Giese, Laurent Daeffler, Celina Czeipluch, Jean Rommelaere, Zahari Raykov
  • Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer
    Publication number: 20160082085
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Application
    Filed: December 3, 2015
    Publication date: March 24, 2016
    Inventors: Zahari RAYKOV, Svitlana GREKOVA, Laurent DAEFFLER, Jean ROMMELAERE, Marc APRAHAMIAN, Nathalia GIESE
  • Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer
    Publication number: 20140328798
    Abstract: The present invention relates to a combination of a parvovirus and a cytokine, preferably IFN?, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 6, 2014
    Inventors: Zahari Raykov, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Compositions comprising a parvovirus VP1-variant and a parvovirus NS1 protein for induction of cytolysis
    Patent number: 8450289
    Abstract: The present invention provides a composition comprising (a) a parvovirus NS1 protein and (b) a parvovirus VP1 protein. Furthermore, the present invention provides DNA sequences encoding said proteins. The composition of the invention is useful for the preparation of a toxin for treating tumoral diseases.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: May 28, 2013
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offenlichen Rechts
    Inventors: Laurent Daeffler, Jurg Nuesch, Jean Rommelaere
  • CO-ADMINISTRATION OF A PARVOVIRUS AND A CYTOKINE FOR THERAPY OF PANCREATIC CANCER
    Publication number: 20130129678
    Abstract: The application relates to a combination of a parvovirus and a cytokine, preferably IFN?, for use in treating pancreatic cancer (PDAC), in particular a terminal stage of this disease.
    Type: Application
    Filed: November 17, 2011
    Publication date: May 23, 2013
    Inventors: Zahari RAYKOV, Svitlana Grekova, Laurent Daeffler, Jean Rommelaere, Marc Aprahamian, Nathalia Giese
  • Diagnostic Method for Predicting the Response of a Patient to Chemovirotherapy or Radiovirotherapy
    Publication number: 20130101989
    Abstract: Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.
    Type: Application
    Filed: April 29, 2011
    Publication date: April 25, 2013
    Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFUNG DES OEFFE, UNIVERSITAETSKLINIKUM HEIDELBERG, RUPRECHT-KARIS-UNIVERSITAET HEIDELBERG
    Inventors: Nathalia Giese, Jens Werner, Markus Buechler, Thomas Giese, Laurent Daeffler, Celina Cziepluch, Jean Rommelaere, Zahari Raykov
  • COMPOSITIONS COMPRISING A PARVOVIRUS VP1-VARIANT AND A PARVOVIRUS NS1 PROTEIN FOR INDUCTION OF CYTOLYSIS
    Publication number: 20100029751
    Abstract: The present invention provides a composition comprising (a) a parvovirus NS1 protein and (b) a parvovirus VP1 protein. Furthermore, the present invention provides DNA sequences encoding said proteins. The composition of the invention is useful for the preparation of a toxin for treating tumoral diseases.
    Type: Application
    Filed: September 30, 2009
    Publication date: February 4, 2010
    Applicant: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Laurent Daeffler, Jurg Nuesch, Jean Rommelaere
  • Composition comprising a parvovirus vp1- variant and a parvovirus ns1 protein for induction of cytolysis
    Publication number: 20040208886
    Abstract: The present invention provides a composition comprising (a) a parvovirus NS1 protein and (b) a parvovirus VP1 protein. Furthermore, the present invention provides DNA sequences encoding said proteins. The composition of the invention is useful for the preparation of a toxin for treating tumoral diseases.
    Type: Application
    Filed: January 8, 2004
    Publication date: October 21, 2004
    Inventors: Laurent Daeffler, Jurg Nuesch, Jean Rommelaere