Patents by Inventor Laurent David

Laurent David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9321748
    Abstract: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: April 26, 2016
    Assignees: H. Lundbeck A/S, Vernalis (R&D) Ltd.
    Inventors: Gitte Kobberøe Mikkelsen, Laurent David, Stephen Watson, Garrick Paul Smith, Douglas Stewart Williamson, I-Jen Chen
  • Patent number: 9315772
    Abstract: The present invention relates to a new method for treating or processing a cross-linked hyaluronan hydrogel prior to its use in applications involving three-dimensional cell culture. The invention also relates to cross-linked hyaluronan hydrogels prepared by such a method and to their use in 3D cell culture, stem cell/tissue engineering, drug discovery, toxicology testing, and broad cell biology applications.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: April 19, 2016
    Assignee: UNIVERSITE DE ROUEN
    Inventors: Jean-Pierre Vannier, Laurent David, Didier Lecerf, Virginie Dulong, Berenice Coquerel, Elise Demange
  • Patent number: 9238880
    Abstract: The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element.
    Type: Grant
    Filed: February 15, 2010
    Date of Patent: January 19, 2016
    Assignees: LABORATOIRE TETRA MEDICAL, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alain Domard, Laurent David, Alexandra Montembault, Mylène Desorme
  • Publication number: 20150368231
    Abstract: The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.
    Type: Application
    Filed: January 27, 2014
    Publication date: December 24, 2015
    Inventors: Philip James Maltas, Stephen Watson, Morten Langgärd, Laurent David
  • Publication number: 20150336942
    Abstract: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
    Type: Application
    Filed: December 30, 2013
    Publication date: November 26, 2015
    Inventors: Gitte Kobberøe Mikkelsen, Laurent David, Stephen Watson, Garrick Paul Smith, Douglas Stewart Williamson, I-Jen Chen
  • Publication number: 20150174298
    Abstract: An implantable material has at least one external surface grafted with a film including carboxylate and sulfonate functions wherein the film is simultaneously synthesized and grafted directly on the external surface by radical reaction of a source of carboxylate functions, the source being either polymerizable or chemisorbable and polymerizable and a source of sulfonate functions, the source being either polymerizable or chemisorbable and polymerizable. A process for simultaneously synthesizing and grafting a film directly onto at least one external surface of an implantable material, and the use of a grafted implantable material for the manufacture of an antiproliferative and/or antibacterial implantable medical device are also described.
    Type: Application
    Filed: June 14, 2013
    Publication date: June 25, 2015
    Applicants: BIOWINTECH, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVE (CEA)
    Inventors: Alexandre Brouzes, Laurent David, Guy Deniau, Maxime Oudin
  • Publication number: 20150174153
    Abstract: The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 ?m (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses. It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.
    Type: Application
    Filed: July 16, 2013
    Publication date: June 25, 2015
    Applicant: UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Fatiha Nothias, Sylvia Soares, Laurent David, Alexandra Montembault
  • Patent number: 9044410
    Abstract: The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: June 2, 2015
    Assignees: UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alain Domard, Laurent David, Florence Dupasquier
  • Publication number: 20150065454
    Abstract: The present invention relates to a homogeneous aqueous solution of injectable chitosan containing a chitosan having a degree of acetylation lower than 20%, said solution containing between 0.1 and 3.5% by weight of chitosan, said solution presenting a pH lower than 6.2, and said aqueous solution being capable of forming crystalline particles of chitosan after injection. The present invention also relates to compounds containing such a homogeneous aqueous solution of chitosan. The invention also relates to such compounds for their use as dermatological or cosmetic compounds, or for their use as a medical device, advantageously as a bioresorbable implant.
    Type: Application
    Filed: November 30, 2012
    Publication date: March 5, 2015
    Inventors: Florence Dupasquier, Laurent David, Thierry Delair
  • Publication number: 20140242146
    Abstract: The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Alain DOMARD, Laurent DAVID, Florence DUPASQUIER
  • Patent number: 8753671
    Abstract: The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: June 17, 2014
    Assignees: Universite Claude Bernard Lyon I, Centre National de la Recherche Scientifique
    Inventors: Alain Domard, Laurent David, Florence Dupasquier
  • Publication number: 20130260464
    Abstract: The present invention relates to a new method for treating or processing a cross-linked hyaluronan hydrogel prior to its use in applications involving three-dimensional cell culture. The invention also relates to cross-linked hyaluronan hydrogels prepared by such a method and to their use in 3D cell culture, stem cell/tissue engineering, drug discovery, toxicology testing, and broad cell biology applications.
    Type: Application
    Filed: June 22, 2011
    Publication date: October 3, 2013
    Inventors: Jean-Pierre Vannier, Laurent David, Didier Lecerf, Virginie Dulong, Berenice Coquerel, Elise Demange
  • Publication number: 20130252498
    Abstract: A method for obtaining an elongate polysaccharide element, in particular a chitosan thread, includes extruding a hydroalcoholic extrusible solution containing a polyalcohol of said polysaccharide through an extrusion die, coagulating the extruded solution by neutralisation, and at least one operation of removing the polyalcohol. The ratio of water to polyalcohol in the extrusible solution is determined such as to obtain in the elongate element a polysaccharide with the crystalline structure thereof mainly in the form of an anhydrous allomorph. Since the polysaccharide used to prepare the extrusible solution has a weight-average molar mass Mw0, the polysaccharide in the elongate element obtained preferably has a weight-average molar mass Mw1 comprised between Mw0 and 0.7 Mw0. Since the purpose is to obtain a chitosan thread, the latter has properties of mechanical strength and flexibility that allow the thread to be tied into overhand knots and to be woven without breaking.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 26, 2013
    Applicant: Laboratoire Tetra Medical
    Inventors: Laurent David, Alexandra Montembault, Mylène Desorme
  • Publication number: 20120040463
    Abstract: The present invention relates to a method for preparing fibers, notably of polysaccharide or collagen, by wet spinning under coagulation, said method notably comprising: a step for extruding a coagulable macromolecular assembly solution through a normal die; at least one partial coagulation cycle comprising a coagulation step on the one hand and a step for interrupting the coagulation on the other hand; and a step for receiving, notably by winding up, the obtained hollow fiber. The invention also relates to multi-membrane hollow fibers consisting of a same macromolecular assembly which may be spun by coagulation, notably a natural or modified natural polysaccharide in the physical hydrogel or partly dehydrated state. Said fibers including at least over their length two superposed coaxial membranes separated from each other by an inter-membrane space. The invention also relates to the spinning device for applying said method.
    Type: Application
    Filed: September 5, 2008
    Publication date: February 16, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Alain Domard, Laurent David, Rocío Nohemí Rivas Araiza
  • Publication number: 20120022242
    Abstract: The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element.
    Type: Application
    Filed: February 15, 2010
    Publication date: January 26, 2012
    Applicants: Laboratoire Tetra Medical, Centre National De La Recherche Scientifique, Universite Claude Bernad Lyon I
    Inventors: Alain Domard, Laurent David, Alexandra Montembault, Mylène Desorme
  • Publication number: 20110280829
    Abstract: Low molecular weight sulphated L-fucose polysaccharide fraction having a molecular weight ranging from 11 to 30 kDa when measured with TEST A, a sulphate content ranging from 10 and 50% w/w relative to the total weight of the fraction, a fucosis content ranging from 30 and 70% w/w relative to the total weight of the fraction, and a polydispersity index ranging from 1 and 2, wherein the fraction is obtainable by free radical depolymerisation of a crude fucan of vegetal origin; process for manufacturing same; pharmaceutical composition and medicament containing same and their use for inhibiting neovascularisation.
    Type: Application
    Filed: January 7, 2010
    Publication date: November 17, 2011
    Applicant: THERAPOL
    Inventors: Laurent David, Laetitia Frank, Rosa Siali, Jean Huet
  • Publication number: 20100310631
    Abstract: The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.
    Type: Application
    Filed: September 26, 2008
    Publication date: December 9, 2010
    Applicants: UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alain Domard, Laurent David, Florence Dupasquier
  • Patent number: 7689435
    Abstract: A method and apparatus are disclosed for managing composite business processes that include multiple trading mechanisms, such as requests for quotes (RFQs), auctions and contracts, or repeat passes through a single trading mechanism. The independence of the individual business processes that manage each trading mechanism is maintained, while each individual business process can be connected to other business processes to form a composite business process. Each individual business process that may be followed by another business process to form a composite process must have at least one state labeled as a conversion state with a conversion transition to another business process. A conversion transition spans the gap between an end state of one business process and the start state of another subsequent business process. When a conversion state is entered by an object, a determination is made as to whether the object is being managed by a composite flow, and if so, what business process to use next.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: March 30, 2010
    Assignee: International Business Machines Corporation
    Inventors: Mitchell Adam Cohen, Titania Mary Gupta, Laurent David Hasson, John Scott Houston, Jianren Li, Rakesh Mohan, Jakka Sairamesh, Josef Schiefer, Revathi Subramanian
  • Publication number: 20090317071
    Abstract: This invention describes a system for the remote control of setting up an adjustable head for optical and/or photo-cinematographic equipment comprising an adjustable head for mounting by adjustable setting-up of optical and/or photo-cinematographic equipment, at least one servomechanism for locking and/or unlocking and/or setting up a movable part of the head in relation to a fixed part thereof, as well as remote control means of said servomechanism for setting up the head comprising at least one pushbutton control, remote in relation to the servomechanism, that can be operated by the user while he is holding said equipment.
    Type: Application
    Filed: April 27, 2007
    Publication date: December 24, 2009
    Inventor: Laurent David
  • Publication number: 20090209736
    Abstract: The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow means being placed between adjacent zones and between the last zone and the first zone, this process comprising several sequences, each sequence comprising at least one step chosen from an absorption step, a rinsing step and a desorption step, carried out either simultaneously or not, each following sequence is carried out by the displacement of the fronts in the zones towards the downstream end substantially of the same increment before the periodic displacement of the points of introduction and of withdrawal, characterized in that the process includes a sub-sequence without injection of the charge.
    Type: Application
    Filed: June 18, 2007
    Publication date: August 20, 2009
    Inventors: Marc-André Theoleyre, Stanislas Baudouin, Annick Merrien, Eric Valery, Olivier Ludemann-Hombourger, Laurent David, Margit Holzer