Patents by Inventor Laurent DeBussche

Laurent DeBussche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPIRO-OXINDOLE MDM2 ANTAGONISTS
    Publication number: 20140148494
    Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 29, 2014
    Applicants: The Regents of the University of Michigan, Sanofi, Ascenta Licensing Corporation
    Inventors: Shaomeng Wang, Yujun Zhao, Wei Sun, Sanjeev Kumar, Lance Leopold, Laurent Debussche, Cedric Barriere, Jean-Christophe Carry, Kwame Amaning
  • COMPOSITIONS AND METHODS FOR TREATING CANCER USING PI3K INHIBITOR AND MEK INHIBITOR
    Publication number: 20140024653
    Abstract: Methods of treating patients with cancer are provided, wherein the methods comprise administering to the patient an effective amount of a MEK inhibitor and an effective amount of a PI3K inhibitor. Compositions in which the MEK and PI3K inhibitors are combined also are described.
    Type: Application
    Filed: June 7, 2013
    Publication date: January 23, 2014
    Applicants: Merck Patent GmbH, Sanofi
    Inventors: Laurent DEBUSSCHE, Carlos GARCIA-ECHEVERRIA, Jianguo MA, Stuart McMillan, Janet Ann Meurer OGDEN, Loic VINCENT
  • SPIRO-OXINDOLE MDM2 ANTAGONISTS
    Publication number: 20120122947
    Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, SANOFI, ASCENTA THERAPEUTICS, INC.
    Inventors: Shaomeng Wang, Yujun Zhao, Wei Sun, Sanjeev Kumar, Lance Leopold, Laurent Debussche, Cedric Barriere, Jean-Christophe Carry, Kwame Amaning
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 7090999
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: August 15, 2006
    Assignee: sanofi-aventis
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Methods of increasing the production of cobalamins using cob gene expression
    Publication number: 20060019352
    Abstract: Novel polypeptides involved in the biosynthesis of cobalamines and/or cobamides, in particular coenzyme B12, genetic material responsible for expressing these polypeptides, and a method for preparing them, are described. A method for amplifying the production of cobalamines, and particularly coenzyme B12, using recombinant DNA techniques, are also described.
    Type: Application
    Filed: December 1, 2003
    Publication date: January 26, 2006
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Laurent Debussche, Sophie Levy Schil, Denis Thibaut
  • Polypeptides (MBP1) capable of interacting with oncogenic mutants of the p53 protein
    Publication number: 20050129698
    Abstract: The invention concerns the field of biology and cell cycle regulation. More particularly, the invention concerns novel polypeptides capable of interacting specifically with an oncogenic form of the p53 protein.
    Type: Application
    Filed: January 20, 2004
    Publication date: June 16, 2005
    Inventors: Emmanuel Conseiller, Laurent Debussche, William Gallagher
  • Anti-P53 single-chain antibody fragments and their uses
    Patent number: 6852509
    Abstract: The invention concerns single-chain antibodies directed against the p53 protein, capable of being expressed in tumoral cells, capable of restoring a DNA binding in vitro and a transcription activator function in vivo. The invention also concerns nucleic acids coding for these molecules, the vectors containing them and their uses.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: February 8, 2005
    Inventors: Laurent Bracco, Laurent Debussche, Claude Caron De Fromentel
  • Streptogramins and method for preparing same by mutasynthesis
    Patent number: 6833382
    Abstract: Novel group B streptogramin-like compounds of general formula (I), and a method for preparing streptogramines by mutasynthesis using a mutated micro-organism to influence the biosynthesis of at least one of the precursors of group B streptogramins are disclosed. Novel nucleotide sequences involved in the biosynthesis of said precursors, and their uses, are also disclosed.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: December 21, 2004
    Assignee: Aventis Pharma S.A.
    Inventors: Véronique Blanc, Denis Thibaut, Nathalie Bamas-Jacques, Francis Blanche, Joël Crouzet, Jean-Claude Barriere, Laurent Debussche, Alain Famechon, Jean-Marc Paris, Gilles Dutruc-Rosset
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Publication number: 20040229236
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Application
    Filed: November 20, 2003
    Publication date: November 18, 2004
    Applicant: Aventis Pharma
    Inventors: Veronique Blanc, Francis Blanche, Joerl Crouzet, Nathalie Jacoues, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6670157
    Abstract: The invention concerns methods for preparing pristinamycin IIB and methods for preparing modified pristinamycin IIB.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: December 30, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Methods of increasing the production of cobalamins using cob gene expression
    Patent number: 6656709
    Abstract: Novel polypeptides involved in the biosynthesis of cobalamines and/or cobamides, in particular coenzyme B12, genetic material responsible for expressing these polypeptides, and a method for preparing them, are described. A method for amplifying the production of cobalamines, and particularly coenzyme B12, using recombinant DNA techniques, are also described.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: December 2, 2003
    Assignee: Rhone-Poulenc Biochimie, et al.
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Laurent Debussche, Sophie Levy Schil, Denis Thibaut
  • Polypeptide (MBP1) capable of interacting with oncogenic mutants of the P53 protein
    Publication number: 20030049699
    Abstract: The invention concerns the field of biology and cell cycle regulation. More particularly, the invention concerns novel polypeptides capable of interacting specifically with an oncogenic form of the p53 protein.
    Type: Application
    Filed: April 11, 2001
    Publication date: March 13, 2003
    Inventors: Emmanuel Conseiller, Laurent Debussche, William Gallagher
  • STREPTOGRAMINS AND METHOD FOR PREPARING SAME BY MUTASYNTHESIS
    Publication number: 20020142947
    Abstract: Novel group B streptogramine-like compounds of general formula (I), and a method for preparing streptogramines by muta-synthesis using a mutated micro-organism to influence the biosynthesis of at least one of the precursors of group B streptogramines, are disclosed. Novel nucleotide sequences involved in the biosynthesis of said precursors, and their uses, are also disclosed.
    Type: Application
    Filed: November 15, 2001
    Publication date: October 3, 2002
    Applicant: Aventis Pharma, S.A.
    Inventors: Veronique Blanc, Denis Thibaut, Nathalie Bamas-Jacques, Francis Blanche, Joel Crouzet, Jean-Claude Barriere, Laurent Debussche, Alain Famechon, Jean-Marc Paris, Gilles Dutruc-Rosset
  • Streptogramins for preparing same by mutasynthesis
    Patent number: 6352839
    Abstract: The invention provides a method for preparing streptogramins using genetically-modified microorganisms to influence the biosynthesis of at least one of the precursors of the group B streptogramins. Cultures of the genetically-modified microorganisms are supplemented with a least one precursor that is different from the streptogramin precursor whose biosynthesis is altered and the streptogramins produced are recovered.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: March 5, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Véronique Blanc, Denis Thibaut, Nathalie Bamas-Jacques, Francis Blanche, Joël Crouzet, Jean-Claude Barriere, Laurent Debussche, Alain Famechon, Jean-Marc Paris, Gilles Dutruc-Rosset
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6171846
    Abstract: The invention concerns mutant microorganisms blocked in a step of Streptogramin biosynthesis and methods for preparing cells blocked in a step of Streptogramin biosynthesis.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia LaCroix, Denis Thibaut, Monique Zagorec, Laurent DeBussche, Valerie De Crecy-Lagard
  • Biosynthesis method enabling the preparation of cobalamins
    Patent number: 6156545
    Abstract: The present invention relates to a biosynthetic process for preparing cobalamines. More precisely, it relates to a process for amplifying the production of cobalamines and, more specifically, of coenzyme B.sub.12 by means of recombinant DNA techniques and/or by means of adding a novel cobalamine precursor.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: December 5, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Laurent Debussche, Denis Thibaut, Elisabeth Remy
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6077699
    Abstract: Disclosed is the nucleic acid sequences for polypeptides and enzymes involved in the biosynthesis of streptogramins from Streptomyces sp. and the corresponding amino acid sequences. Also disclosed are recombinant vectors and cells as well as methods of making the polypeptides, enzymes and streptogramins using the recombinant host cells.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: June 20, 2000
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 5891695
    Abstract: The invention concerns nucleotide sequences coding for a polypeptide involved in Streptogramin biosynthesis, recombinant cells containing said sequences, and use thereof.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: April 6, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard