Abstract: A lockable syringe, which includes a syringe body having a longitudinal axis and including a distal end and a proximal end, and a locking mechanism, wherein the locking mechanism is configured to be attached to the proximal end of the syringe body. The locking mechanism includes: a plunger having at least one distal plate, and a rod with visual elements for marking an unlock position; and a locking ring which is free in its rotation about the longitudinal axis of the syringe body, the locking ring has at least two visual indicators on its outer surface, and the locking ring has elements for blocking the plunger stroke in a locked position.

Abstract: The application relates to compositions containing 2?-FL and DFL for use in a method of reducing pain and/or the perception of visceral pain in a non-infant human.

Abstract: The present invention relates to compositions comprising a mix of human milk oligosaccharides consisting of 2?-fucosyllactose and difucosyllactose, for use in the reduction of pain and/or perception of pain in an infant or in a young child. The compositions are particularly effective in the restoration of the sensitivity of the bi-directional pain transmission pathways in the gut-brain axis to normal levels. The compositions are in particular useful in reducing abdominal pain, such as pain associated with gastrointestinal discomfort, functional gastrointestinal disorders, and/or gastrointestinal diseases and consequently also contribute to reducing the crying periods and to improving the quality of sleep, the general quality of life, the mood, the playfulness, the temperament and/or the happiness of the infants and young children.

Abstract: A method, in one embodiment, includes administering to a non-infant human an effective amount of a combination of the human milk oligosaccharides (“HMO”s) 2?-FL and DFL, where the amount of the combination of HMOs is effective for modulating the microbiota of the non-infant human and reducing one or more post-treatment condition such as pain and/or a perception of visceral pain in the non-infant human.