Abstract: Fuse, comprising at least one fuse blade in which is formed a reduced section (46A) defining a plane (P4) transverse to the fuse blade. The fuse also comprises arc guards, which are made of an elastic material and which are associated in pairs, the arc guards of the same pair being each disposed opposite one another on one respective main side of the same fuse blade. Each arc guard comprises an internal face, oriented towards the fuse blade, a front face, oriented towards the reduced section, and a rear face, oriented away from the reduced section. At least one perforation is made in the fuse blade in the vicinity of the reduced section, each perforation being at least partially closed by the internal faces of the two arc guards of the same pair, each perforation leaving a cavity between the two arc guards of the same pair.

Abstract: An apparatus and a method are provided for a patient-specific instrument guide for arthroplasty or other operations on bone tissue, capable of limiting bone cuts, achieving optimal implant positioning, and providing improved stability of implants. The patient-specific instrument guide comprises a body that includes a bone contact surface configured to contact a bone surface of a patient. The body is configured to be 3D printed according to medical imaging of a patient's anatomy, such that the bone contact surface optimally contacts the surface of the patient's bone. The body includes one or more guide slots that each slidably receives a cutting guide. The cutting guides are configured to receive a saw blade during bone cutting. The cutting guides may be oriented to guide cutting a talus or a tibia during a total ankle arthroplasty surgery.

Abstract: A method for imaging a structure composed of at least one wave guide connected to a junction, the structure supporting elastic wave guided propagation modes, the method includes the following steps: for at least one operating frequency, acquiring a plurality of measurements of signals propagating in the structure by means of a plurality of pairs of non-colocalized elastic wave sensors, determining a plurality of propagation modes guided by the structure, correcting the measurements on the basis of ultrasound signals measured or simulated for the same structure in the absence of any defect, converting the measurement matrix M into a wave field scattering matrix U, determining, at each point of a sampling grid, a test vector F characteristic of the structure without any defect, applying a numerical inversion method to determine a vector H of modal components such that U.H=F at each point of a sampling grid, determining an image of the structure on the basis of the vector H.

Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of conforming surfaces and support elements to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves shoulder arthroplasty, a PSI system includes at least one shoulder PSI operable to be positioned on a bone in a shoulder in the patient. The at least one shoulder PSI allow for the transfer of preoperative planning to intra-operative procedures. The at least one shoulder PSI may be virtually designed as a model based on scan data of the bone in the shoulder of the patient. The at least one shoulder PSI may be fabricated based on the virtually-designed at least one shoulder PSI model.

Abstract: An apparatus and a method are provided for a patient-specific instrument guide for arthroplasty or other operations on bone tissue, capable of limiting bone cuts, achieving optimal implant positioning, and providing improved stability of implants. The patient-specific instrument guide comprises a body that includes a bone contact surface configured to contact a bone surface of a patient. The body is configured to be 3D printed according to medical imaging of a patient's anatomy, such that the bone contact surface optimally contacts the surface of the patient's bone. The body includes one or more guide slots that each slidably receives a cutting guide. The cutting guides are configured to receive a saw blade during bone cutting. The cutting guides may be oriented to guide cutting a talus or a tibia during a total ankle arthroplasty surgery.

Abstract: Described herein are methods of treating RNA virus infections with a therapeutic combination of an antiviral nucleobase compound and a de novo nucleotide biosynthesis inhibitor (DNNBi). An aspect of the invention is a method for the treatment of an RNA virus infection comprising administering a therapeutic combination as a combined formulation or by alternation to a patient, wherein the therapeutic combination comprises therapeutically effective amounts of (i) an antiviral nucleobase or a pharmaceutically acceptable salt thereof, and (ii) a de novo nucleotide biosynthesis inhibitor (DNNBi) or a pharmaceutically acceptable salt thereof.

Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of guide elements and feature to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves ankle arthroplasty, a PSI system includes a tibial PSI operable to be coupled to a tibia and a talar PSI operable to be coupled to a talus. Pins pass through the tibial PSI into the tibia and through the talar PSI into the talus. The tibia and talus are aligned based on the tibial PSI, the talar PSI, the pins, and optionally a connection guide operable to receive, or be coupled to, the pins. The tibial PSI and the talar PSI allow for the transfer of pre-operative planning to intra-operative procedures.

Abstract: The invention relates to quinazoline derivatives of formula (I), wherein in is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C1-5akylR3 (wherein R3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkynylR3 (wherein R3 is as defined hereinbefore); 3) C2-5alkynylR3 (wherein R3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Abstract: An implantable ankle-prosthesis component (1), comprising a main body (2) with a bone contact face (3) intended to come into contact with an area of a bone body of an ankle and extending along a median contact plane (Pc), and comprising a anchoring means (4) protruding from the bone contact face (3), the anchoring means (4) comprising two pairs (20A, 20B) of anchoring wings, each extending in a plane (P1, P2), respectively, orthogonal to said median contact plane (Pc) between a first end (23A, 23B) connected to said bone contact face (3) and an opposite second end (24A, 24B), the planes of extension (P1, P2) of the pairs (20A, 20B) of anchoring wings intersecting each other, said second ends (24A, 24B) of the pairs (20A, 20B) of anchoring wings being inscribed in a leading plane (Pa) inclined with respect to said median contact plane (Pc).

Abstract: Embodiments herein disclose automated methods and systems to fill background and interstitial space in the visual object layout with one or more colors that bleed/blend into each other. Embodiments herein automate the creation of multi-colored backgrounds for filling the interstitial space.

Abstract: The invention concerns an ankle prosthesis (100), comprising a talar component (200) which includes a talar upper face (201) defining a first articular surface (202) and which extends between a talar anterior edge (203) and an opposite talar posterior edge (204) according to a first average direction, said first articular surface (202) being curved according to said first average direction, said first articular surface (202) comprising a first curved portion (202A) and a second curved portion (202B), each extending according to said first average direction, said first curved portion (202A) having a first curvature and said second curved portion (202B) having a second curvature, said prosthesis (100) being characterized in that said first curved portion (202A) and said second curved portion (202B) define respectively an anterior portion and a posterior portion of said first articular surface (202), said first curvature being greater than said second curvature.

Abstract: The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. A method is also provided for treating a subject in need thereof by administering the combination of adrenaline with an antidepressant. The pharmaceutical composition is to be administered by injection.

Abstract: Embodiments herein disclose methods and systems for applying content aware stickers onto a layout (wherein the layout can be a digital layout or a physical layout) and the stickers can add a decorative or narrative element about the images and/or the layout.

Abstract: The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C1-5alkylR3 (wherein R3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkenylR3 (wherein R3 is as defined hereinbefore); 3) C2-5alkynylR3 (wherein R3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Abstract: Embodiments herein disclose methods and systems for determining the structure of a sorted collection list of layouts by optimizing the organization of a collection of objects on a layout based on series of narrative and aesthetic criteria that vary for each set of objects and/or layout.

Abstract: Embodiments herein disclose methods and systems for decorating and embellishing interstitial space in a digital object layout using one or more design elements. Embodiments herein place one or more embellishments on any layout of 1-dimensional objects in a sequential manner by automatically detecting one or more “potential” regions/locations of placement (computed rectangular whitespace on edge, computed rectangular whitespace inside, geometric corners/vertices). One or more embellishments are placed in the one or more determined regions/locations using aesthetic measurements (measurement of nearest and furthest neighbor, chamfer radius around corners, number of objects overlaid on one side against the number of objects overlaid on the other side) and a rule based system. Embodiments herein disclose one or more specific design rules that enable a layout with embellishments to look aesthetically pleasing.

Abstract: The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R? represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C1-5alkylR3 (wherein R3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkenylR3 (wherein R3 is as defined hereinbefore); 3) C2-5alkynylR3 (wherein R3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Abstract: Embodiments herein disclose automated methods and systems to fill background and interstitial space in the visual object layout with one or more colors that bleed/blend into each other. Embodiments herein automate the creation of multi-colored backgrounds for filling the interstitial space.

Abstract: Embodiments herein disclose methods and systems for decorating and embellishing interstitial space in a digital object layout using one or more design elements. Embodiments herein place one or more embellishments on any layout of 1-dimensional objects in a sequential manner by automatically detecting one or more “potential” regions/locations of placement (computed rectangular whitespace on edge, computed rectangular whitespace inside, geometric corners/vertices). One or more embellishments are placed in the one or more determined regions/locations using aesthetic measurements (measurement of nearest and furthest neighbor, chamfer radius around corners, number of objects overlaid on one side against the number of objects overlaid on the other side) and a rule based system. Embodiments herein disclose one or more specific design rules that enable a layout with embellishments to look aesthetically pleasing.