Patents by Inventor Laurent Germain

Laurent Germain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200009050
    Abstract: The present invention relates to a pharmaceutical composition comprising the combination of (i) a biocompatible nanoparticle and of (ii) a pharmaceutical compound of interest, to be administered to a subject in need of such a compound of interest, wherein the nanoparticle potentiates the compound of interest efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm, and its absolute surface charge value is of at least 10 mV (|10 mV|). The invention also relates to such a composition for use for administering the compound of interest to a subject in need thereof, wherein the nanoparticle and the compound of interest are to be administered to said subject between more than 5 minutes and about 72 hours from each other.
    Type: Application
    Filed: August 29, 2019
    Publication date: January 9, 2020
    Inventors: AGNÈS POTTIER, LAURENT LEVY, MARIE-EDITH MEYRE, AUDREY DARMON, MATTHIEU GERMAIN
  • Publication number: 20190374465
    Abstract: The present invention relates to a pharmaceutical composition comprising the combination of (i) at least two distinct biocompatible nanoparticles and (ii) at least one compound of interest, typically at least one pharmaceutical compound, to be administered to a subject in need of such at least one compound of interest, wherein the at least two distinct biocompatible nanoparticles potentiate the compound(s) of interest efficiency. The at least two biocompatible nanoparticles can be administered sequentially or simultaneously to the subject but are to be administered separately, typically with an interval of between more than about 5 minutes and about 72 hours, from the at least one compound of interest, preferably before the administration of the at least one compound of interest, to said subject. The longest dimension of the at least two biocompatible nanoparticles is typically between about 4 nm and about 500 nm.
    Type: Application
    Filed: August 26, 2019
    Publication date: December 12, 2019
    Inventors: MATTHIEU GERMAIN, MARIE-EDITH MEYRE, AGNÈS POTTIER, LAURENT LEVY
  • Publication number: 20190314530
    Abstract: The present invention relates to compositions and methods for use in medical diagnosis and patient monitoring, typically in the context of therapy, in particular in the context of oncology, to optimize tumor bed local irradiation. It more particularly relates to a biocompatible gel comprising nanoparticle and/or nanoparticle aggregates, wherein: i) the density of each nanoparticle and of each nanoparticle aggregate is at least 7 g/cm3, the nanoparticle or nanoparticles of the aggregate comprising an inorganic material comprising at least one metal element having an atomic number Z of at least 25, more preferably of at least 40, each of said nanoparticle and nanoparticle aggregate being covered with a biocompatible coating; ii) the nanoparticles' and/or nanoparticle aggregates' concentration is of at least about 1% (w/w); and iii) the apparent viscosity at 2 s?1 of the gel comprising nanoparticles and/or nanoparticle aggregates is between about 0.1 Pa·s and about 1000 Pa·s when measured between 20° C.
    Type: Application
    Filed: May 28, 2019
    Publication date: October 17, 2019
    Inventors: LAURENCE POUL, LAURENT LEVY, CELINE BERJAUD, MATTHIEU GERMAIN, AGNÉS POTTIER
  • Patent number: 10413509
    Abstract: The present invention relates to a pharmaceutical composition comprising the combination of (i) a biocompatible nanoparticle and of (ii) a pharmaceutical compound of interest, to be administered to a subject in need of such a compound of interest, wherein the nanoparticle potentiates the compound of interest efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm, and its absolute surface charge value is of at least 10 mV (|10 mV|). The invention also relates to such a composition for use for administering the compound of interest to a subject in need thereof, wherein the nanoparticle and the compound of interest are to be administered to said subject between more than 5 minutes and about 72 hours from each other.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: September 17, 2019
    Assignee: NANOBIOTIX
    Inventors: Agnés Pottier, Laurent Levy, Marie-Edith Meyre, Audrey Darmon, Matthieu Germain
  • Patent number: 10391058
    Abstract: The present invention relates to a pharmaceutical composition comprising the combination of (i) at least two distinct biocompatible nanoparticles and (ii) at least one compound of interest, typically at least one pharmaceutical compound, to be administered to a subject in need of such at least one compound of interest, wherein the at least two distinct biocompatible nanoparticles potentiate the compound(s) of interest efficiency. The at least two biocompatible nanoparticles can be administered sequentially or simultaneously to the subject but are to be administered separately, typically with an interval of between more than about 5 minutes and about 72 hours, from the at least one compound of interest, preferably before the administration of the at least one compound of interest, to said subject. The longest dimension of the at least two biocompatible nanoparticles is typically between about 4 nm and about 500 nm.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: August 27, 2019
    Assignee: NANOBIOTIX
    Inventors: Matthieu Germain, Marie-Edith Meyre, Agnes Pottier, Laurent Levy
  • Patent number: 8434447
    Abstract: This invention relates to a double-plenum or double-chamber inlet manifold or splitter, made up of a structural unit comprising two distinct coupled plenums with a common wall, an inlet opening for each of the two plenums and several pipes through each of the said plenums, the said superimposed plenums having substantially flattened general structures and forming, with their respectively connected inlet openings and pipes, two independent circulation circuits running from the entrance at the inlet openings to the outlet at the external openings of the pipes, the said external or outlet openings of the pipes being grouped in pairs, with each pair having an opening of each of the two types of pipes; the manifold comprises two one-piece parts assembled together, in a gas-tight manner, at the continuous assembly areas, a first part incorporating at least the two inlet openings and first portions of the walls of the two plenums, contiguous to the said openings and the second part incorporating the pipes and second
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: May 7, 2013
    Assignee: Systemes Moteurs (SAS)
    Inventors: Laurent Germain, Denis Menin
  • Patent number: 8082900
    Abstract: A method for producing a support plate (1) for valve bodies includes: i) providing a base armature (22) including an even number of portions of pipes (4, 4?); ii) arranging a valve body (5) on portions (19) of the base armature (22) forming temporary reception zones for a valve body (5); iii) mounting the control axis through bearings (7 and 9) and the transverse groove of each valve body (5); iv) molding onto the control axis a bearing support for each valve body (5) and a mounting insert in the corresponding guide bearing (7); v) mounting each valve body (5) on the corresponding bearing support by sliding on the control axis, and vi) inserting mounting inserts in the corresponding guide bearings (7).
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: December 27, 2011
    Assignee: Mark IV Systemes Moteurs (SAS)
    Inventors: Laurent Germain, Denis Menin, Richard Komurian
  • Patent number: 7771502
    Abstract: An air-filter device for a motor vehicle, having a casing and a filtering body separating the clean and dirty compartment, and also having a supporting body for the filtering body and a compression body designed to co-operate mechanically with the supporting body, these bodies being mounted in the manner of sliding drawers in an intermediate mounting compartment; the contact surfaces in mutual sliding bearing of the support and compression bodies are inclined in such a way that the forced stress position leading to a compression of the seal of the filtering body is achieved by displacement of the compression body in the direction of extraction and in that the control device, bringing about this displacement, stresses the supporting body and/or the casing in order to achieve the displacement of the compression body in a forced stress position, at least at the end of displacement.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: August 10, 2010
    Assignee: Mark IV Systemes Moteurs (SAS)
    Inventors: Laurent Germain, François Cottet, Hugues Winkelmuller
  • Publication number: 20090194060
    Abstract: A method for producing a support plate (1) for valve bodies includes: i) providing a base armature (22) including an even number of portions of pipes (4, 4?); ii) arranging a valve body (5) on portions (19) of the base armature (22) forming temporary reception zones for a valve body (5); iii) mounting the control axis through bearings (7 and 9) and the transverse groove of each valve body (5); iv) moulding onto the control axis a bearing support for each valve body (5) and a mounting insert in the corresponding guide bearing (7); v) mounting each valve body (5) on the corresponding bearing support by sliding on the control axis, and vi) inserting mounting inserts in the corresponding guide bearings (7).
    Type: Application
    Filed: February 4, 2009
    Publication date: August 6, 2009
    Applicant: MARK IV SYSTEMES MOTEURS
    Inventors: Laurent GERMAIN, Denis MENIN, Richard KOMURIAN
  • Publication number: 20090071430
    Abstract: This invention relates to a double-plenum or double-chamber inlet manifold or splitter, made up of a structural unit comprising two distinct coupled plenums with a common wall, an inlet opening for each of the two plenums and several pipes through each of the said plenums, the said superimposed plenums having substantially flattened general structures and forming, with their respectively connected inlet openings and pipes, two independent circulation circuits running from the entrance at the inlet openings to the outlet at the external openings of the pipes, the said external or outlet openings of the pipes being grouped in pairs, with each pair having an opening of each of the two types of pipes; the manifold comprises two one-piece parts assembled together, in a gas-tight manner, at the continuous assembly areas, a first part incorporating at least the two inlet openings and first portions of the walls of the two plenums, contiguous to the said openings and the second part incorporating the pipes and second
    Type: Application
    Filed: July 11, 2008
    Publication date: March 19, 2009
    Applicant: MARK IV SYSTEMES MOTEURS (SAS)
    Inventors: Laurent Germain, Denis Menin
  • Publication number: 20080211194
    Abstract: A method for producing a hollow part formed from at least two portions joined together along respective adjacent edges, or at least portions of such edges, producing at the same time a seal in the region of the assembly zone, the method consisting in producing a first portion by moulding of a first thermoplastic material, this first portion comprising at least one rib or ridge protruding in the region of its edge or its assembly edge portion, then in producing a second portion by moulding onto the first portion of a second thermoplastic material, with at least partial overmoulding of the edge or the assembly edge portion of the first portion by the second material mass forming the edge or the assembly edge portion of the second portion, or an extension of this edge, said second material entirely covering said at least one rib or ridge.
    Type: Application
    Filed: January 30, 2008
    Publication date: September 4, 2008
    Inventors: Denis Menin, Laurent Germain, Lionel Verchere
  • Publication number: 20080110146
    Abstract: An air-filter device for a motor vehicle, having a casing and a filtering body separating the clean and dirty compartment, and also having a supporting body for the filtering body and a compression body designed to co-operate mechanically with the supporting body, these bodies being mounted in the manner of sliding drawers in an intermediate mounting compartment; the contact surfaces in mutual sliding bearing of the support and compression bodies are inclined in such a way that the forced stress position leading to a compression of the seal of the filtering body is achieved by displacement of the compression body in the direction of extraction and in that the control device, bringing about this displacement, stresses the supporting body and/or the casing in order to achieve the displacement of the compression body in a forced stress position, at least at the end of displacement.
    Type: Application
    Filed: November 7, 2007
    Publication date: May 15, 2008
    Inventors: Laurent GERMAIN, Francois COTTET, Hugues WINKELMULLER
  • Patent number: 7165539
    Abstract: An air inlet module incorporating, in one structural unit, on the one hand, a supply manifold, on the other hand, an exhaust gas reinjection circuit and, finally, a gas/liquid heat exchanger designed to cool the exhaust gases, the module consisting of a sealed assembly of at most four parts, namely, a first part comprising the inlet manifold, the outlet manifolds, a portion of the supply conduit, and a hollow body forming the tank of the exchanger, a second part comprising the many circulation manifolds and a support body for assembling said manifolds in the tank, and a third part of which one portion forms a cover for the hollow open container and comprising several conduit portions forming at least partially the exhaust gas circulation circuit and conveying these gases to the inlet manifold, also incorporated in said third part.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: January 23, 2007
    Assignee: Mark IV Systemes Moteurs Societe Anonyme
    Inventors: Denis Menin, Laurent Germain, Jean-Paul Vaudry
  • Publication number: 20050263142
    Abstract: An air inlet module incorporating, in one structural unit, on the one hand, a supply manifold, on the other hand, an exhaust gas reinjection circuit and, finally, a gas/liquid heat exchanger designed to cool the exhaust gases, the module consisting of a sealed assembly of at most four parts, namely, a first part comprising the inlet manifold, the outlet manifolds, a portion of the supply conduit, and a hollow body forming the tank of the exchanger, a second part comprising the many circulation manifolds and a support body for assembling said manifolds in the tank, and a third part of which one portion forms a cover for the hollow open container and comprising several conduit portions forming at least partially the exhaust gas circulation circuit and conveying these gases to the inlet manifold, also incorporated in said third part.
    Type: Application
    Filed: May 25, 2005
    Publication date: December 1, 2005
    Inventors: Denis Menin, Laurent Germain, Jean-Paul Vaudry