Abstract: A method of mixing a liquid composition that includes microparticles dispersed in an aqueous liquid carrier may involve a first premixing step and a second premixing step. During the first premixing step a receptacle is oscillated about a longitudinal axis clockwise and counter-clockwise from a first reference point through a first angle of rotation for a first period of time and at a first angular velocity. During the second premixing step the receptacle is oscillated about the longitudinal axis clockwise and counter-clockwise from a second reference point through a second angle of rotation for a second period of time and at a second angular velocity. In examples, the first angle of rotation is smaller than said second angle of rotation, and the first period of time is shorter than the second period of time.

Abstract: It is disclosed a method of mixing a liquid composition, wherein said liquid composition comprises microparticles dispersed in an aqueous liquid carrier and wherein said liquid composition is contained in a receptacle having a longitudinal axis, the method comprising: a first premixing step in which the receptacle is oscillated about said longitudinal axis clockwise and counter-clockwise from a first reference point through a first angle of rotation for a first period of time and at a first angular velocity; a second premixing step in which the receptacle is oscillated about said longitudinal axis clockwise and counter-clockwise from a second reference point through a second angle of rotation for a second period of time and at a second angular velocity; and wherein said first angle of rotation is smaller than said second angle of rotation, and said first period of time is shorter than said second period of time. Also disclosed is a device for mixing a liquid composition.

Abstract: A kit comprising a medical dispensing container (402), such as a vial for diagnostic agents, and a liquid transfer device (401) to be used to transfer a liquid into or from said dispensing container. The transfer device allows substantially limiting the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Abstract: A device for administering a liquid preparation comprising a pharmaceutical agent, particularly a contrast agent, in the form of a bolus. The device comprises in particular a core cylinder and an external cylinder, the core cylinder comprising a conduit (107) and a cylindrical reservoir (108) cooperating with a respective plunger (109), wherein the plunger is modified in order to operatively engage with guiding means (300) provided on the external cylinder.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Abstract: A device for administering a liquid preparation comprising a pharmaceutical agent, particularly a contrast agent, in the form of a bolus. The device comprises in particular a core cylinder and an external cylinder, the core cylinder comprising a conduit (107) and a cylindrical reservoir (108) cooperating with a respective plunger (109), wherein the plunger is modified in order to operatively engage with guiding means (300) provided on the external cylinder.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Abstract: A kit comprising a medical dispensing container (402), such as a vial for diagnostic agents, and a liquid transfer device (401) to be used to transfer a liquid into or from said dispensing container. The transfer device allows substantially limiting the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Abstract: Liquid transfer device to be used to transfer a liquid into or from a dispensing container, particularly a medical dispensing container like a vial for diagnostic agents and kit comprising a vial, a syringe and a device of the aforementioned type. The transfer device comprises a valve which substantially limits the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.