Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of the interleukin 15R alpha (IL-15R?) or derivatives thereof; and uses thereof.

Abstract: A liquefaction system is capable of sequentially or simultaneously liquefying multiple feed streams of hydrocarbons having different normal bubble points with minimal flash. The liquefying heat exchanger has separate circuits for handling multiple feed streams. The feed stream with the lowest normal boiling point is sub-cooled sufficiently to suppress most of the flash. Feed streams with relatively high normal boiling points are cooled to substantially the same temperature, then blended with bypass streams to maintain each product near its normal bubble point. The system can also liquefy one stream at a time by using a dedicated circuit or by allocating the same feed to multiple circuits.

Abstract: Aspects of the present invention relate to an induction heating system for heating a component. The induction heating system includes a power module for outputting an alternating current, the power module being operable to output the alternating current at a variable supply frequency. A controller is provided to identify at least one resonant frequency of the alternating current supplied to the at least one induction element. The controller is configured to determine an operating temperature of the component in dependence on the at least one identified resonant frequency. Aspects of the present also relate to an induction heating controller; a component comprising an induction heating element; and to a method of heating a component by inductive heating.

Abstract: The present disclosure relates to a thermal management system (2) configured to heat a conduit (4) composed of metal. The thermal management system (2) includes an electrical generator (16) for generating alternating current at a high frequency. First and second electrical connectors (19, 20) are provided for connecting the electrical generator (16) to the conduit (4). In use, the electrical generator (16) outputs alternating current at a high frequency to the first and second electrical connectors (19, 20), the alternating current being introduced into the conduit (4) and causing direct heating of the conduit (4). The present disclosure also relates to an exhaust system (1) comprising a comprising a thermal management system (2); and to a related method of heating a conduit (4).

Abstract: A liquefaction system is capable of sequentially or simultaneously liquefying multiple feed streams of hydrocarbons having different normal bubble points with minimal flash. The liquefying heat exchanger has separate circuits for handling multiple feed streams. The feed stream with the lowest normal boiling point is sub-cooled sufficiently to suppress most of the flash. Feed streams with relatively high normal boiling points are cooled to substantially the same temperature, then blended with bypass streams to maintain each product near its normal bubble point. The system can also liquefy one stream at a time by using a dedicated circuit or by allocating the same feed to multiple circuits.

Abstract: A monitoring apparatus comprises at least one sensor for measuring a current of the electric motor to generate a time-based signal and at least one electronic processor configured to transform the time-based signal into a frequency-based signal and to analyse the frequency-based signal to identify a signal pattern representing a pump fault condition. By monitoring the frequency-based signal, the monitoring apparatus can identify a pump fault condition.

Abstract: A liquefaction system is capable of sequentially or simultaneously liquefying multiple feed streams of hydrocarbons having different normal bubble points with minimal flash. The liquefying heat exchanger has separate circuits for handling multiple feed streams. The feed stream with the lowest normal boiling point is sub-cooled sufficiently to suppress most of the flash. Feed streams with relatively high normal boiling points are cooled to substantially the same temperature, then blended with bypass streams to maintain each product near its normal bubble point. The system can also liquefy one stream at a time by using a dedicated circuit or by allocating the same feed to multiple circuits.

Abstract: A liquefaction system is capable of sequentially or simultaneously liquefying multiple feed streams of hydrocarbons having different normal bubble points with minimal flash. The liquefying heat exchanger has separate circuits for handling multiple feed streams. The feed stream with the lowest normal boiling point is sub-cooled sufficiently to suppress most of the flash. Feed streams with relatively high normal boiling points are cooled to substantially the same temperature, then blended with bypass streams to maintain each product near its normal bubble point. The system can also liquefy one stream at a time by using a dedicated circuit or by allocating the same feed to multiple circuits.

Abstract: A monitoring apparatus comprises at least one sensor for measuring a current of the electric motor to generate a time-based signal and at least one electronic processor configured to transform the time-based signal into a frequency-based signal and to analyse the frequency-based signal to identify a signal pattern representing a pump fault condition. By monitoring the frequency-based signal, the monitoring apparatus can identify a pump fault condition.

Abstract: The present invention relates to a vacuum pumping system (10) which comprises: a vacuum pumping mechanism (12) and a motor (14) for driving the vacuum pumping mechanism. Means (16) are provided for determining a cumulative load on the vacuum pumping system over time by monitoring a characteristic of the motor over that time. Means (18) are also provided for activating a maintenance activity on the system when the cumulative load exceeds a predetermined amount.

Abstract: The invention relates to a method for removing water from a mixture containing at least one compound having at least one group reactive towards isocyanate and containing water, the mixture being applied to the surface of a rotating body A, the mixture flowing over the surface of the rotating body A to an outer region of the surface of the rotating body A and water evaporating from the mixture. In particular, this method is suitable for removing water from alcohols and amines.

Abstract: The present invention relates to a reduced fat bakery emulsion comprising 39-65 wt. % of a continuous fat phase and 35-61 wt. % of a dispersed aqueous phase, said aqueous phase having the following composition: 60-80 wt. % of water; 18-40 wt. % of maltodextrin with a DE in the range of 1-5; 0-5 wt. % of other hydrocolloids; 0-6 wt. % of dissolved components selected from acids, salts and combinations thereof; 0-2 wt. % of other edible ingredients; said continuous fat phase having the following composition: 94-99.5 wt. % of triglycerides; 0.5-5 wt. % of emulsifier; 0-2 wt. % of other edible ingredients; wherein the fat phase is characterized by the following solid fat profile: 25%?N20?50; 15%?N30?35%; 8%?N35?30%. The bakery emulsion of the present invention enables the preparation of low fat puff pastries of high quality.

Abstract: The invention relates to a process for the preparation of copolymers containing acid monomer structural units and polyether macromonomer structural units, which is carried out in a continuous mode of operation in a reactor which has ?) a body B rotating about an axis of rotation and having a reaction surface, ?) a metering system and ?) a device for irradiating the reaction surface, i) the components of a starting reaction composition being applied individually and/or as a mixture with the aid of the metering system in a thin film on an inner region of the reaction surface of the rotating body B so that the thin film flows over the reaction surface of the rotating body B to an outer region of the reaction surface of the rotating body B, the thin film on the reaction surface being electromagnetically irradiated by means of the device for the irradiation of the reaction surface, ii) the thin film leaving the reaction surface as a reaction composition which has copolymer containing acid monomer structural uni

Abstract: The present invention provides a pumping system (60) comprising: a pumping mechanism (64); a motor (51) for driving the pumping mechanism; a drive control (50) for controlling the motor; and means (52) for monitoring at least one state within the system; wherein, to improve the performance of the system, the drive control causes the system to operate for transient periods in an overload condition which can result in said monitored state exceeding a predetermined operational limit, and when operating in said overload condition said drive control controls the power to the motor dependent on the level of said monitored state thereby avoiding said state from exceeding said operational limit.

Abstract: The invention relates to a process for the preparation of silylated polyurethanes and/or polyureas, comprising the steps: a) application of a component ?) containing isocyanate and of a component ?) containing polyol and/or polyamine to at least one surface of body A, which surface rotates about an axis of rotation and has a temperature between 60 and 400° C., and b) reaction of the reaction product of ?) isocyanate and ?) polyol and/or polyamine with a silylating agent.

Abstract: The invention relates to a process for the preparation of metal nanoparticles, selected from the group consisting of lead, bismuth, zinc, antimony, indium, gold, nickel, cobalt, palladium, platinum, iridium, osmium, rhodium, ruthenium, rhenium, vanadium, chromium, manganese, niobium, molybdenum, tungsten, tantalum, cadmium, silver and/or copper, on a rotating body, characterized in that a reduction of corresponding metal salts, corresponding metal salt complexes, corresponding metal hydroxides and/or corresponding metal oxides by polyols having a number of hydroxyl groups in the polyol of 1 to 10 and a molecular weight of the polyols of 2000 to 18 000 Da is effected.

Abstract: The present invention relates to a method for removing isocyanate from a reaction product of isocyanate with compounds reactive towards isocyanates, the reaction product being applied to the surface of a rotating body A, the reaction product flowing over the surface of the rotating body A to an outer region of the surface of the rotating body A and isocyanate which was used for the preparation of the reaction product and has not reacted evaporating from the mixture in the process.

Abstract: The invention relates to a method for removing water from a mixture containing at least one compound having at least one group reactive towards isocyanate and containing water, the mixture being applied to the surface of a rotating body A, the mixture flowing over the surface of the rotating body A to an outer region of the surface of the rotating body A and water evaporating from the mixture. In particular, this method is suitable for removing water from alcohols and amines.

Abstract: The present invention relates to a vacuum pumping system (10) which comprises: a vacuum pumping mechanism (12) and a motor (14) for driving the vacuum pumping mechanism. Means (16) are provided for determining a cumulative load on the vacuum pumping system over time by monitoring a characteristic of the motor over that time. Means (18) are also provided for activating a maintenance activity on the system when the cumulative load exceeds a predetermined amount.

Abstract: The invention relates to a process for the preparation of a polymeric mixture, comprising a first polymerization step in which substantially monomer M is reacted by atom transfer radical polymerization in a mixture which contains a transition metal salt, a ligand having at least two chelating sites, an atom transfer radical polymerization initiator, a reducing agent and monomer M, and a second polymerization step in which monomer S substituted by silyl groups is added to the mixture obtained from the first polymerization step, so that monomer S substituted by silyl groups is reacted by atom transfer radical polymerization in the mixture obtained from the first polymerization step. The polymeric mixture obtained is used as a binder additive for sealants.