Patents by Inventor Laurent Menard

Laurent Menard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11073507
    Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 27, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 11067537
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: July 20, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 11053535
    Abstract: Devices, such as chips for DNA analysis, have at least one fluid transport nanochannel with at least one intersecting (e.g., transverse) sensing nanochannel that can be monitored for change in ionic current to determine characteristics or parameters of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Jean Pierre Alarie, Laurent Menard
  • Patent number: 10996212
    Abstract: Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length, with width and depth dimensions that both vary over its length and forming (e.g., milling) at least one nanochannel into the planar substrate at an interface adjacent the narrow end of the nanofunnel.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: May 4, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard, Jinsheng Zhou, Michael Rubinstein, Sergey Panyukov
  • Publication number: 20200150085
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 10571428
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: February 25, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 10478158
    Abstract: The invention concerns a preoperative probe (2) for guiding an ablation tool, comprising a sensing head (21), said sensing head including: at least one optic fiber (2121, 2123) for receiving and guiding a signal emitted, by radioactive tracers and/or fluorescent molecules in a tissue zone, to an analyzing equipment (32), fixing means (2112) for mounting the head (21) on the ablation tool (1), such that the ablation tool is capable of extracting a portion of tissue in the tissue zone emitting the signal.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: November 19, 2019
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Laurent Menard, Sébastien Bonzom, Yves Charon, Marie-Alix Duval, Françoise Lefebvre, Stéphane Palfi, Laurent Pinot, Rainer Siebert, Stéphanie Pitre
  • Publication number: 20190210020
    Abstract: Nanofluidic chips are described herein that are configured for high-volume manufacturing and maintaining sample integrity in multiplexed devices comprising: at least two devices, wherein each device comprises at least one sample inlet and at least one nanochannel; and a detection region, wherein the at least two devices pass through the detection region and wherein the at least two devices are fluidically distinct from the inlet through the detection region, and wherein actuation energy can be applied independently to at least two devices.
    Type: Application
    Filed: January 3, 2019
    Publication date: July 11, 2019
    Inventors: Jeff KROGMEIER, Hardeep SINGH, Robert DUBROW, Laurent MENARD, Andrew GOLDEN, Samrudhi SHARMA
  • Publication number: 20190210016
    Abstract: A fluidic chip for detecting an analyte is provided, which comprises (a) at least one device comprising (i) a fluid inlet and (ii) at least one fluid transport channel that passes through a detection region, wherein (1) the at least one fluid transport channel has varying cross-sectional area as a function of position along the channel length and/or (2) the device comprises two or more fluid transport channels configured with two or more different cross-sectional areas; and (b) at least one fluid outlet, wherein the device provides for transport of single molecules across the detection region at a desired duty cycle by (1) allowing for detection of an analyte at a different position along the channel length based on the desired cross-sectional area and/or (2) allowing for detection of an analyte in a specific channel configured with the desired cross-sectional area. This application also provides for method of optimizing duty cycle using fluidic chips.
    Type: Application
    Filed: January 3, 2019
    Publication date: July 11, 2019
    Inventors: Qun ZHONG, Jeff KROGMEIER, Andrew GOLDEN, Samrudhi SHARMA, Laurent MENARD, Andrew WATSON, Oscar MCCRATE, Jun ZHOU, Rachel ROWELL
  • Publication number: 20190187123
    Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 10261065
    Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: April 16, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Publication number: 20190033255
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 31, 2019
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 10106848
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: October 23, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Publication number: 20180252697
    Abstract: Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length, with width and depth dimensions that both vary over its length and forming (e.g., milling) at least one nanochannel into the planar substrate at an interface adjacent the narrow end of the nanofunnel.
    Type: Application
    Filed: May 2, 2018
    Publication date: September 6, 2018
    Inventors: John Michael Ramsey, Laurent Menard, Jinsheng Zhou, Michael Rubinstein, Sergey Panyukov
  • Publication number: 20180224398
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 9, 2018
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 9989515
    Abstract: Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length, with width and depth dimensions that both vary over its length and forming (e.g., milling) at least one nanochannel into the planar substrate at an interface adjacent the narrow end of the nanofunnel.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: June 5, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard, Jinsheng Zhou, Michael Rubinstein, Sergey Panyukov
  • Patent number: 9970898
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: May 15, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 9775573
    Abstract: A peroperative probe for guiding a manual excision tool. The probe includes a detection head, an optical fiber for the reception and guidance of a signal emitted by radioactive tracers and fluorescent molecules in a tissue area, a photo-detector for converting the emitted signal into an electrical signal, a transmitter for transmitting information carried by the electrical signal to an analysis equipment, and a fastener for attaching the probe onto the manual excision tool, so that the excision tool can be used to remove a portion of tissue from the tissue area emitting the signal.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: October 3, 2017
    Assignee: Centre National De La Recherche Scientifique
    Inventors: Laurent Menard, Sebastien Bonzom, Yves Charon, Marie-Alix Duval, Francoise Lefebvre-Bouvet, Stephane Palfi, Laurent Pinot, Rainer Siebert, Stephanie Pitre
  • Publication number: 20170175181
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: March 1, 2017
    Publication date: June 22, 2017
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 9618479
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 11, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard