Patents by Inventor Laurent Oliver Chorro

Laurent Oliver Chorro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FimH mutants and uses thereof
    Patent number: 12357681
    Abstract: This disclosure relates to the design of E. coli mutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, and uses thereof.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: July 15, 2025
    Assignee: Pfizer Inc.
    Inventors: Ye Che, Laurent Oliver Chorro, Robert George Konrad Donald, Matthew Curtis Griffor, Natalie Clare Silmon de Monerri
  • ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
    Publication number: 20250121044
    Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
    Type: Application
    Filed: September 9, 2024
    Publication date: April 17, 2025
    Inventors: Robert G.K. Donald, Annaliesa Sybil Anderson, Laurent Oliver Chorro, Jianxin Gu, Jin-Hwan Kim, Srinivas Kodali, Jason Arnold Lotvin, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, Ling Chu, Scott Ellis Lomberk, Karen Kiyoko Takane, Nishith Merchant, Wei Chen
  • ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
    Publication number: 20250114442
    Abstract: This invention relates to compositions that include a polypeptide derived from E. coli or a fragment thereof; and modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof, and methods of use thereof.
    Type: Application
    Filed: September 9, 2024
    Publication date: April 10, 2025
    Inventors: Annaliesa Sybil Anderson, Laurent Oliver Chorro, Robert George Konrad Donald, Jacqueline Marie Lypowy, Rosalind Pan
  • compositions and methods thereof
    Patent number: 12138302
    Abstract: This invention relates to compositions that include a polypeptide derived from E. coli or a fragment thereof; and modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof, and methods of use thereof.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: November 12, 2024
    Assignee: Pfizer Inc.
    Inventors: Annaliesa Sybil Anderson, Laurent Oliver Chorro, Robert George Konrad Donald, Jacqueline Marie Lypowy, Rosalind Pan
  • compositions and methods thereof
    Patent number: 12128095
    Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: October 29, 2024
    Assignee: Pfizer Inc.
    Inventors: Robert G. K. Donald, Annaliesa Sybil Anderson, Laurent Oliver Chorro, Jianxin Gu, Jin-Hwan Kim, Srinivas Kodali, Jason Arnold Lotvin, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, Ling Chu, Scott Ellis Lomberk, Karen Kiyoko Takane, Nishith Merchant, Wei Chen
  • ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
    Publication number: 20230000966
    Abstract: In one aspect, the invention relates to a polypeptide derived from E. coli and a fragment thereof, including compositions and methods thereof. Also disclosed herein are compositions that include a polypeptide derived from E. coli and a fragment thereof; and modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. In a further aspect, disclosed herein are mammalian host cells that include sequence(s) encoding a polypeptide derived from E. coli or fragments thereof.
    Type: Application
    Filed: October 28, 2020
    Publication date: January 5, 2023
    Inventors: Annaliesa Sybil Anderson, Ye Che, Wei Chen, Laurent Oliver Chorro, Ling Chu, Robert G.K. Donald, Matthew Curtis Griffor, Jianxin Gu, Zeqiang Guan, Jin-Hwan Kim, Srinivas Kodali, Scott Ellis Lomberk, Jason Arnold Lotvin, Nishith Merchant, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, David Robert Stead, Karen Kiyoko Takane
  • E. COLI FIMH MUTANTS AND USES THEREOF
    Publication number: 20220202923
    Abstract: This disclosure relates to the design of E. coli mutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, and uses thereof.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 30, 2022
    Applicant: Pfizer Inc.
    Inventors: Ye Che, Laurent Oliver Chorro, Robert George Konrad Donald, Matthew Curtis Griffor, Natalie Clare Silmon de Monerri
  • ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
    Publication number: 20220168410
    Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
    Type: Application
    Filed: February 15, 2022
    Publication date: June 2, 2022
    Applicant: Pfizer Inc.
    Inventors: Robert G.K. Donald, Annaliesa Sybil Anderson, Laurent Oliver Chorro, Jianxin Gu, Jin-Hwan Kim, Srinivas Kodali, Jason Arnold Lotvin, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, Ling Chu, Scott Ellis Lomberk, Karen Kiyoko Takane, Nishith Merchant, Wei Chen
  • ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
    Publication number: 20220152181
    Abstract: This invention relates to compositions that include a polypeptide derived from E. coli or a fragment thereof; and modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof, and methods of use thereof.
    Type: Application
    Filed: October 25, 2021
    Publication date: May 19, 2022
    Applicant: Pfizer Inc.
    Inventors: Annaliesa Sybil Anderson, Laurent Oliver Chorro, Robert George Konrad Donald, Jacqueline Marie Lypowy, Rosalind Pan
  • compositions and methods thereof
    Patent number: 11260119
    Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: March 1, 2022
    Assignee: Pfizer Inc.
    Inventors: Robert G. K. Donald, Annaliesa Sybil Anderson, Laurent Oliver Chorro, Jianxin Gu, Jin-Hwan Kim, Srinivas Kodali, Jason Arnold Lotvin, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, Ling Chu, Scott Ellis Lomberk, Karen Kiyoko Takane, Nishith Merchant, Wei Chen
  • ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
    Publication number: 20200061177
    Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
    Type: Application
    Filed: August 7, 2019
    Publication date: February 27, 2020
    Inventors: Robert G.K. Donald, Annaliesa Sybil Anderson, Laurent Oliver Chorro, Jianxin Gu, Jin-Hwan Kim, Srinivas Kodali, Jason Arnold Lotvin, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, Ling Chu, Scott Ellis Lomberk, Karen Kiyoko Takane, Nishith Merchant, Wei Chen