Abstract: Provided is a process for grafting a substituted difluoromethyl group onto a compound bearing at least one electrophilic substituent, comprising (i) contacting the compound bearing at least one electrophilic substituent with a nucleophilic reagent which comprises (a) a fluorocarboxylic acid having the formula Ea—CF2—COOH, wherein Ea is an electron-withdrawing atom or group, the fluorocarboxylic acid being at least partially salified with an organic or inorganic cation and (b) a polar aprotic solvent, and (ii) exposing the resulting medium of reaction to the action of microwave energy.

Abstract: The invention features the use of fluorosulphonates to release the organic bases from their fluorohydrate. This use is characterised in that a hydrogenofluorosulphonate of an organic base is formed and in that the hydrofluoric acid which is associated with the said base or with one of its precursors is separated therefrom. The invention is useful in organic synthesis applications.

Abstract: The invention features a useful method for the synthesis of fluorinated derivatives. It is characterized in that it comprises at least one step in which a substrate comprising one sp.sup.3 hybridizing halogenophore carbon bearing at least two halogens, at least one of which is a halogen of an atomic number higher than that of fluorine, which halogenophore carbon is coupled to at least one weak hybridization atom bearing an unsaturation, is subjected to the action of one reagent comprising at least one defined compound selected among those constituted by the association of one Bronstedt base with a defined number n of hydrofluoric acid, n being at least 3 and at most 20, advantageously 15, preferably 10. This invention is useful in organic synthesis.

Abstract: The invention relates to a reagent which is useful for the synthesis of oxysulphide-containing fluorine-containing organic derivatives by reacting with an oxide of sulphur, especially sulphur dioxide, characterized in that it comprises:a) a fluorocarboxylic acid of formula E.sub.w --CF.sub.2 --COOH where E.sub.w is an electron-withdrawing group or atom which is at least partially salified by an organic or inorganic cation, andb) an aprotic polar solvent; andin that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid.This reagent can be used by heating in order to form fluorine-containing sulphinic or sulphonic acids.

Abstract: The invention relates to a process and a nucleophilic reagent which is useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function, characterized in that it comprises:a) a fluorocarboxylic acid of formula Ew--CF.sub.2 --COOH where Ew represents an electron-withdrawing atom or group, at least partially salified with an organic or inorganic cation, andb) a polar aprotic solvent;and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid.