Abstract: The present disclosure relates to a process for preparing a Lawsonia inermis extract which is rich in Lawsone. It also relates to the extract which may be obtained by said process and to a composition comprising thereof. The disclosure also relates to a method for dying fibers, in particular keratin fibers.

Abstract: The invention relates to an extract of the aerial parts of Lawsonia inermis, as well as its preparation method and the extract that can be obtained by said method. The invention also relates to a cosmetic dye composition comprising such an extract. The invention finally concerns a cosmetic method for dying keratin fibers comprising the application of such a composition.

Abstract: The invention relates to an extract of the aerial parts of Lawsonia inermis, as well as its preparation method and the extract that can be obtained by said method. The invention also relates to a cosmetic dye composition comprising such an extract. The invention finally concerns a cosmetic method for dying keratin fibers comprising the application of such a composition.

Abstract: The present invention relates to the use of a cosmetic composition intended for colouring the skin, said cosmetic composition including, as an active principle, an aqueous extract of gardenia.

Abstract: The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt2, wherein M represents an alkaline metal, or with NHEt2 in the presence of a Lewis acid-amine complex, in order to obtain an amide-alcohol; (c) reaction of said amide-alcohol with thionyl chloride in order to obtain a chlorinated amide; (d) reaction of said chlorinated amide with a phthalimide salt in order to obtain a phthalimide derivative; (e) hydrolysis of the phthalimide group of said phthalimide derivative in order to obtain (1S, 2R)-milnacipran, and (f) salification of (1S, 2R)-milnacipran in a suitable solvent system in the presence of a pharmaceutically acceptable acid.

Abstract: The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt2, wherein M represents an alkaline metal, or with NHEt2 in the presence of a Lewis acid-amine complex, in order to obtain an amide-alcohol; (c) reaction of said amide-alcohol with thionyl chloride in order to obtain a chlorinated amide; (d) reaction of said chlorinated amide with a phthalimide salt in order to obtain a phthalimide derivative; (e) hydrolysis of the phthalimide group of said phthalimide derivative in order to obtain (1S, 2R)-milnacipran, and (f) salification of (1S, 2R)-milnacipran in a suitable solvent system in the presence of a pharmaceutically acceptable acid.