Abstract: Provided is a method and system of sound processing for a mobile terminal based on hand-holding and orientation detection. The method includes: detecting whether the mobile terminal is held by hand; in response to determination of the mobile terminal being held by hand, detecting whether it is one-hand holding or two-hand holding; in response to determination of one-hand holding, detecting whether it is landscape holding or portrait holding, and conducting corresponding frequency response equalization and stereo processing control; and in response to determination of two-hand holding, determining whether the mobile terminal is in an interaction procedure, and conducting corresponding frequency response equalization and stereo processing control.