Patents by Inventor Laurie Ozelius

Laurie Ozelius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic Acids, Methods and Kits for the Diagnosis of DYT6 Primary Torsion Dystonia
    Publication number: 20230043763
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Application
    Filed: July 13, 2022
    Publication date: February 9, 2023
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia
    Patent number: 11421275
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: August 23, 2022
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic Acids, Methods and Kits for the Diagnosis of DYT6 Primary Torsion Dystonia
    Publication number: 20190241959
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Application
    Filed: December 11, 2018
    Publication date: August 8, 2019
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia
    Patent number: 10167510
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: January 1, 2019
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic Acids, Methods and Kits for the Diagnosis of DYT6 Primary Torsion Dystonia
    Publication number: 20160222454
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Application
    Filed: March 17, 2016
    Publication date: August 4, 2016
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia
    Patent number: 9322064
    Abstract: This invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: April 26, 2016
    Assignees: Icahn School of Medicine at Mount Sinai, Beth Israel Medical Center
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic Acids, Methods and Kits for the Diagnosis of DYT6 Primary Torsion Dystonia
    Publication number: 20140147844
    Abstract: This invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Application
    Filed: October 23, 2013
    Publication date: May 29, 2014
    Applicant: Icahn School of Medicine of Mount Sinai
    Inventors: Laurie Ozelius, Susan Bressman
  • Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia
    Patent number: 8568980
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: October 29, 2013
    Assignees: Mount Sinai School of Medicine, Beth Israel Medical Center
    Inventors: Laurie Ozelius, Susan Bressman
  • NUCLEIC ACIDS, METHODS AND KITS FOR THE DIAGNOSIS OF DYT6 PRIMARY TORSION DYSTONIA
    Publication number: 20110020802
    Abstract: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Application
    Filed: January 27, 2010
    Publication date: January 27, 2011
    Applicant: Mount Sinai School of Medicine of New York University
    Inventors: Laurie Ozelius, Susan Bressman
  • Genetic diagnosis of torsion dystonia
    Patent number: 5407821
    Abstract: Methods are provided for detecting the presence of a gene for torsion dystonia in a human subject. Furthermore, a haplotype which is associated with torsion dystonia is disclosed. Methods and kits for the detection of torsion dystonia in a subject are additionally provided.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: April 18, 1995
    Assignee: The General Hospital Corporation
    Inventors: Xandra O. Breakefield, Laurie Ozelius