Abstract: A catheter handle 10 includes a handle body (12). A steering control mechanism (14) is displaceably carried on the handle body (12). An electrode sheath carrier (16) is carried on the handle body (12), the electrode sheath carrier (16) being displaceable at least relative to the steering control mechanism (14).

Abstract: A catheter handle (10) includes a handle body (12) having a proximal end (14) and a distal end (16) with a receiving formation (18) being defined at the distal end (16) for receiving a catheter arrangement. A steering control mechanism (22) is carried by the handle body (12), a steering device of the catheter arrangement being connectable to the steering control mechanism (22). At least one introducer zone (24) is defined by a part of the handle body (12) and is in communication with the distal end (16) of the handle body (12). A shape forming element is able to be introduced, in use, via the introducer zone (24) into a lumen of a catheter of the catheter arrangement received by the receiving formation (18).

Abstract: Sealant and potting formulations comprising a thioether-functional, oligomeric polythiol prepared by reacting together: (a) a compound having at least two thiol functional groups; and (b) a compound having triple bond functionality are disclosed.

Abstract: The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging. The method is used to monitor delivery of antitumor drugs to tumors and may be used to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g., 11C-paclitaxel and 11C-docetaxel, labeled anthracyclines, e.g., 11C-doxorubicin and 11C-epirubicin, and other radio-labeled drug, e.g. 11C-topotecan and 11C-mitoxantrone. The invention further describes antitumor drugs labeled with the radioactive label 11C and methods of preparing radio-labeled drugs.

Abstract: Film-forming compositions are disclosed that are substantially free of organic solvent. The film-forming compositions include a resinous binder and at least one water dilutable additive including the reaction product of (i) a reactant including at least one isocyanate functional group with (ii) an active hydrogen containing alkoxypolyalkylene compound. Also disclosed are multi-layer composite coatings that include such film-forming compositions and methods of applying such multi-component composite coatings to a substrate.

Abstract: An improvement relating to an infinitely variable ratio transmission having a pair of oppositely oriented variable diameter torque input and output pulleys is disclosed wherein the conical surfaces of the pulleys include a multiplicity of axially and circumferentially movable sprocket bars to accommodate the fixed length of an inextensible drive belt or chain wrapping about the pulleys.

Abstract: A method of preparing an organic sol of particles is provided. Steps include: a) providing a suspension of particles in an aqueous medium; b) adding an organic liquid to form an admixture where the concentration of particles in the admixture is less than or equal to 40 percent by weight; c) maintaining the admixture at a temperature and pressure and for a time sufficient to reduce the water content to less than 30 percent by weight while simultaneously adding a water-compatible organic liquid at a rate sufficient to maintain a concentration of particles in the admixture at less than or equal to 50 percent by weight; and d) adding at least one polymer while maintaining the admixture at a temperature and pressure and for a time sufficient to provide an organic sol of particles comprising 1 percent by weight or less of water.

Abstract: The present invention provides an improved multi-layer composite of two or more polymeric layers at least one of which is formed from a thermosetting composition. The composite includes at least a first polymeric layer formed on a substrate and a second polymeric layer over the first polymeric layer, wherein in the absence of a boron-containing compound, the first and second polymeric layers have poor interlayer adhesion. The improvement resides in the inclusion of at least one boron-containing compound in one or both of the first and second polymeric layers in an amount sufficient to improve the interlayer adhesion between the first and second polymeric layers. Also provided is an improved curable coating composition used to form a multi-layer composite coating of two or more cured coating layers, at least one of which is formed from the thermosetting composition. Related methods and coated substrates are also provided.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analog which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analog compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: An improvement relating to an infinitely variable ratio transmission having a pair of oppositely oriented variable diameter torque input and output pulleys is disclosed wherein the conical surfaces of the pulleys include a multiplicity of axially and circumferentially movable sprocket bars to accommodate the fixed length of an inextensible drive belt or chain wrapping about the pulleys.

Abstract: An infinitely variable ratio transmission having a pair of oppositely oriented conical torque input and output members wherein the conical members include multi-angled conical surfaces. Further the conical members include longitudinal floating sprocket bars which combined with the multi angled conical surfaces compensate for the effect of an inextensible drive belt as the drive belt is axially moved along the longitudinal length of the torque input and output members.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.

Abstract: An improvement relating to an infinitely variable ratio transmission having a pair of oppositely oriented conical torque input and output members is disclosed wherein the conical members include multi-angled conical surfaces. Further the conical members include longitudinal floating sprocket bars which combined with the multi angled conical surfaces compensate for the effect of an inextensible drive belt as the drive belt is axially moved along the longitudinal length of the torque input and output members.

Abstract: Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.