Patents by Inventor Lawrence A. Bottomley

Lawrence A. Bottomley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer micro-cantilever with probe tip and method for making same
    Publication number: 20070237676
    Abstract: A micro-cantilever includes a base, a micro-cantilever beam and a tip. The micro-cantilever beam extends outwardly from the base and is constructed from a material including a thermoplastic polymer material. The micro-cantilever beam has a distal end opposite the base. The tip extends transversely from the distal end. The tip is constructed from a material including a thermoplastic polymer material and is integrated with the micro-cantilever beam. To make a micro-cantilever, a mold defining a cavity having a geometry of a micro-cantilever is formed and an indentation corresponding to an image of a probe tip is formed in the mold. Molten thermoplastic is injected into the mold.
    Type: Application
    Filed: October 14, 2005
    Publication date: October 11, 2007
    Inventors: Jonathan Colton, Andrew McFarland, Mark Poggi, Lawrence Bottomley
  • Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors
    Patent number: 7141385
    Abstract: An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the microcantilever.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: November 28, 2006
    Assignee: Protiveris, Inc.
    Inventors: Lawrence A. Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul, Sebastian Kossek, Gary W. Pace
  • Microfluidics apparatus and methods of use therefor
    Publication number: 20050176034
    Abstract: A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell receives a different sample fluid. A plurality of microcantilevers may be disposed in each of the interaction cells, wherein each of the plurality of microcantilevers configured to deflect in response to an interaction involving a component of the sample fluid.
    Type: Application
    Filed: November 18, 2004
    Publication date: August 11, 2005
    Inventors: John Peeters, Thomas Wiggins, Madhushree Ghosh, Lawrence Bottomley, Salvatore Seminara, Zhiyu Hu, Timothy Seeley, Sebastian Kossek
  • Microfluidics apparatus and methods for use thereof
    Patent number: 6926864
    Abstract: A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell receives a different sample fluid. A plurality of microcantilevers may be disposed in each of the interaction cells, wherein each of the plurality of microcantilevers configured to deflect in response to an interaction involving a component of the sample fluid.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: August 9, 2005
    Inventors: John P. Peeters, Thomas Wiggins, Madhushree Ghosh, Lawrence A. Bottomley, Salvatore Seminara, Zhiyu Hu, Timothy Seeley, Sebastian Kossek
  • Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors
    Publication number: 20040029108
    Abstract: An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectively, attached to a surface of the microcantilever.
    Type: Application
    Filed: January 17, 2003
    Publication date: February 12, 2004
    Inventors: Lawrence A. Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul, Sebastian Kossek, Gary W. Pace
  • Microfluidics apparatus and methods for use thereof
    Publication number: 20030092016
    Abstract: A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell receives a different sample fluid. A plurality of microcantilevers may be disposed in each of the interaction cells, wherein each of the plurality of microcantilevers configured to deflect in response to an interaction involving a component of the sample fluid.
    Type: Application
    Filed: November 13, 2001
    Publication date: May 15, 2003
    Inventors: Thomas Wiggins, Madhushree Ghosh, Lawrence A. Bottomley, Salvatore Seminara, Zhiya Hu, Timothy Seeley, Sebastian Kossek
  • Microcantilever apparatus and methods for detection of enzymes
    Publication number: 20030068655
    Abstract: An apparatus and a method are provided for detecting an enzyme by measuring a change in defection of a microcantilever having a substrate for the enzyme.
    Type: Application
    Filed: September 12, 2001
    Publication date: April 10, 2003
    Applicant: Protiveris, Inc.
    Inventors: Lawrence A. Bottomley, Madhushree Ghosh, Shanxiang Shen, Richard Saul