Patents by Inventor Lawrence A. Rheins

Lawrence A. Rheins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11849923
    Abstract: A transdermal oxygen patch measures an oxygen concentration based on transcutaneous oxygen diffusing through an epidermal surface of a patient. Transcutaneous oxygen differs from hemoglobin-bound oxygen often measured in a patient blood flow. The patch employs an indicator responsive to an oxygen presence for emitting light having an intensity and lifetime (duration) based on the oxygen presence. An optical receptor is in communication with logic for receiving the intensity of emitted light and computing the oxygen concentration based on the received intensity and lifetime (duration). A wireless transmitter conveys the results to a base station or monitoring counterpart for untethered patient monitoring. Low power demands and circuit footprint are amenable to a wearable device such as a patch for continuous use.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: December 26, 2023
    Assignee: Worcester Polytechnic Institute
    Inventors: Ulkuhan Guler, Ian Costanzo, Devdip Sen, Lawrence Rhein
  • Publication number: 20210106316
    Abstract: A transdermal oxygen patch measures an oxygen concentration based on transcutaneous oxygen diffusing through an epidermal surface of a patient. Transcutaneous oxygen differs from hemoglobin-bound oxygen often measured in a patient blood flow. The patch employs an indicator responsive to an oxygen presence for emitting light having an intensity and lifetime (duration) based on the oxygen presence. An optical receptor is in communication with logic for receiving the intensity of emitted light and computing the oxygen concentration based on the received intensity and lifetime (duration). A wireless transmitter conveys the results to a base station or monitoring counterpart for untethered patient monitoring. Low power demands and circuit footprint are amenable to a wearable device such as a patch for continuous use.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 15, 2021
    Inventors: Ulkuhan Guler, Ian Costanzo, Devdip Sen, Lawrence Rhein
  • Publication number: 20080254150
    Abstract: Botanically-sourced and botanically-derived emollient sanitation compositions for topical use are disclosed. Representative compositions generally aid reconstitution of the lipid profile of the stratum corneum by providing botanical lipids and/or lipid-derivatives that resemble human sebum—these components being ordinarily diminished with the use of conventional hand sanitizer products. Disclosed features and specifications may be variously controlled, adapted or optionally modified to realize, for example, improved hand sanitizer formulations. Representative embodiments of the present invention generally provide anti-microbial compositions blended with botanically sourced lipids and/or lipid-derivatives to control or otherwise improve dermatitic symptoms associated with frequent use of conventional hand sanitizer products.
    Type: Application
    Filed: March 31, 2008
    Publication date: October 16, 2008
    Inventors: Lawrence A. Rheins, John C. Hill, David Ashley, James S. Brown, John Reinhardt, James H. Brown
  • Patent number: 6949338
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: September 27, 2005
    Assignee: DermTech International
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Patent number: 6720145
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: April 13, 2004
    Assignee: Dermtech International
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Publication number: 20020197604
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: August 17, 1999
    Publication date: December 26, 2002
    Inventors: LAWRENCE A. RHEINS, VERA B. MORHENN
  • Publication number: 20020150918
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: October 11, 2001
    Publication date: October 17, 2002
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Publication number: 20020127573
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: October 3, 2001
    Publication date: September 12, 2002
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Publication number: 20020119471
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: October 11, 2001
    Publication date: August 29, 2002
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Publication number: 20020115086
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: October 5, 2001
    Publication date: August 22, 2002
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Publication number: 20020110822
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: September 28, 2001
    Publication date: August 15, 2002
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Publication number: 20020110824
    Abstract: Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. Additionally, provided are methods for non-invasive isolation of samples from the skin as well as kits for use in the methods provided herein.
    Type: Application
    Filed: October 12, 2001
    Publication date: August 15, 2002
    Inventors: Lawrence A. Rheins, Vera B. Morhenn
  • Patent number: 4874744
    Abstract: Dermatitis is treated by topically applying a composition including melanocyte stimulating hormone to the epidermal portion of the infected skin. Preferably, alpha-melanocyte stimulating hormone is applied in a concentration in the range of about 5.times.10.sup.-5 M/cm.sup.2. This is an effective treatment against a broad range of dermatitis. Occlusion of the affected site enhances response.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: October 17, 1989
    Assignee: University of Cincinnati
    Inventors: James J. Nordlund, Lawrence A. Rheins