Patents by Inventor Lawrence A. Shimp

Lawrence A. Shimp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210369462
    Abstract: Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.
    Type: Application
    Filed: August 16, 2021
    Publication date: December 2, 2021
    Inventor: Lawrence A. Shimp
  • Patent number: 11116638
    Abstract: Methods for preparing bone void filler substrates with carbonate surface coatings to promote bone growth.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: September 14, 2021
    Assignee: CaP Biomaterials, LLC
    Inventor: Lawrence A. Shimp
  • Patent number: 10603407
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 31, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Abdulhafez A. Selim, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Publication number: 20190350716
    Abstract: Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 21, 2019
    Inventor: Lawrence A. Shimp
  • Patent number: 10368995
    Abstract: Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: August 6, 2019
    Assignee: CaP Biomaterials, LLC
    Inventor: Lawrence A. Shimp
  • Patent number: 10322209
    Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: June 18, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd Boyce, Lawrence A. Shimp
  • Patent number: 10111983
    Abstract: Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 30, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Lawrence A. Shimp
  • Patent number: 10098681
    Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: October 16, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Guobao Wei, Todd M. Boyce, Robert Cohen, Cristy Richards, Lawrence A. Shimp
  • Publication number: 20180250442
    Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
    Type: Application
    Filed: May 8, 2018
    Publication date: September 6, 2018
    Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd Boyce, Lawrence A. Shimp
  • Patent number: 10028837
    Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: July 24, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth, John Winterbottom, James Beisser, Todd Boyce, Mohamed Attawia, Cristy J. Richards, Lawrence A. Shimp
  • Patent number: 10016457
    Abstract: Carbonated calcium phosphate compositions and methods of preparation, affording enhanced biophysical properties.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: July 10, 2018
    Assignee: CaP Biomaterials, LLC
    Inventor: Lawrence A. Shimp
  • Patent number: 9999520
    Abstract: An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: June 19, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Albert Manrique, Jean T. Edwards, Nelson L. Scarborough, Scott D. Boden, Kathy Traianedes, Lawrence A. Shimp, James L. Russell
  • Patent number: 9993579
    Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: June 12, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
  • Publication number: 20180133014
    Abstract: Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.
    Type: Application
    Filed: November 14, 2017
    Publication date: May 17, 2018
    Inventor: Lawrence A. Shimp
  • Publication number: 20180099009
    Abstract: A delivery system and method suitable for delivering a fluid to an interior of a bone and for removing fluid including bodily material from the interior of the bone. The delivery system includes a proximal portion graspable by a user and in fluid communication with a source of negative pressure and a delivery fluid. A delivery cannula has a length sufficient to extend from the proximal portion to a distal tip insertable into the interior of the bone to deliver the delivery fluid into the bone. A removal cannula has a length sufficient to extend from the proximal portion to a distal tip insertable into the interior of the bone to withdraw fluid including bodily material from the bone.
    Type: Application
    Filed: March 15, 2016
    Publication date: April 12, 2018
    Inventors: Francois BINETTE, Lawrence A. SHIMP
  • Patent number: 9849215
    Abstract: Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture; and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: December 26, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Christina Mossaad, Lawrence A. Shimp, Guobao Wei, John Winterbottom
  • Publication number: 20170304496
    Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 26, 2017
    Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
  • Patent number: 9789223
    Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: October 17, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
  • Patent number: 9771410
    Abstract: Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: September 26, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Nels Lauritzen, Lawrence A. Shimp, Brent S. Mitchell
  • Patent number: 9649341
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 16, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Abdulhafez A. Selem, Lawrence A. Shimp, Hsiu Ying Sherry Wang