Abstract: h The present disclosure provides compositions, methods, and systems related to template-mediated genome editing and modification. In particular, the present disclosure provides novel genome modification technology involving site-specific chemical modification of a nucleotide to introduce a replication-blocking lesion. The compositions, methods, and systems described herein facilitate efficient site-specific genome modification of a DNA target, while minimizing the unintended edits and cellular toxicity associated with current genome editing approaches.

Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.

Abstract: The present disclosure relates to enhancements in diagnostic assays for detection of analytes. The improved assays are suitable for management of infections and pandemics in humans and animal reservoirs, including but not limited to SARS-CoV-2 (CoV2), and for measurement of biomarkers of disease (both human and veterinary).

Abstract: A semiconductor device includes a backside power rail, a backside ground rail, and a backside isolation rail between the backside power rail and the backside ground rail. The backside isolation rail may provide adequate electrical isolation between the backside power rail and the backside ground rail, thereby enabling the backside power rail and the backside ground rail to be located relatively near to one another. The backside isolation rail may also cure actual electrical shorts between the backside power rail and the backside ground rail.

Abstract: A vehicle detection system warns snowmobilers of other approaching vehicles with potential risk of collision. To better prevent accidents, the system calculates collision risks and warns the rider based on level of risk. When riding in groups, a member can press a stop request button to ask the group to slow down. When a member exits the group, everyone in the group will receive a message, alerts or indication with the update. The vehicle detection system utilizes Bluetooth® low energy (BLE), LoRaWAN® technologies and/or global positioning system technologies and is designed to detect other devices in the region and use acquired information to calculate proximity and risk of collision.

Abstract: A breathing air laboratory on location gas sample test and data collecting system and method, at a remote breathing air provider's facility, that includes an air compressor, for remotely testing, collecting, and monitoring the quality and purity of the breathing air being produced at the provider's facility, that allows an accredited independent monitoring, testing, and analyzing facility to provide breathing air validation and certification to a cloud-based air quality test and analysis account belonging to the breathing air provider facility at any time. The system includes redundant gas sample air sensors for O2 and CO to ensure quality and accuracy in the breathing air test and data collection, and analysis and a “canary” gas sample test module securely mounted in a laboratory chassis, but manually swappable, to ensure credibility and accuracy of the sensors being used to test gas/air samples.

Abstract: Techniques described herein relate to a method for identifying offline accounts for online adoption targeting, including obtaining an account group data set; generating, using the account group data set, an enhanced account group data set comprising the account group data set and a derived data item; obtaining, using a ML model and the enhanced account group data set, a key metric set; performing a clustering analysis using the key metric set and a portion of the enhanced account group data set to obtain account clusters; assigning a weight to a cluster of the account clusters; performing a similarity computation for an offline account of the account group using the key metric set and the portion of the enhanced account group data set to obtain a weighted similarity score; adding the weighted similarity score to a ranked list of weighted similarity scores; and providing the ranked list to an interested entity.

Abstract: A drain system includes a drain body attachable to a subfloor and configured for attachment to a pipe member below the subfloor. A seal component is positionable between the drain body and the pipe member and is arranged to form a seal therebetween. The seal component has a body including open upper and lower ends defining an opening therethrough for receiving a portion of the pipe member. An outer surface of the body defines an interface between the seal component and the drain body arranged to permit a first angular movement between the seal component and the drain body. An inner surface defines an interface between the seal component and the pipe member and is arranged to seal and permit a second angular movement between the seal component and the pipe member, wherein the second angular movement is different than the first angular movement.

Abstract: A digital file forensic accounting and management system collects forensic data for a digital file that is stored and accounted for in a datastore. The digital files and the associated forensic data may be retrieved from the datastore by a third party to verify the authenticity of the digital file. An interface program is utilized to collect forensic data about a file upon creation of the file and/or when the file is transferred to the datastore. An interface program may be a framework that is operated on a file producing program that a file provider used to create a digital file. An interface program may be an origination driver that is operated on the file providing computer. An interface program may be a directory monitoring program that transfers the digital file and forensic data to the datastore upon saving the file to the monitored directory.

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: Disclosed herein are a group anchor system, subsea installation tool and method of install such group anchor systems. The group anchor system includes a template through which a plurality of vertical piles, such as helical piles, are passed, drilled into the seabed at one end and secured to the template at the other to provide a mooring anchor for an offshore asset. The installation tool is a modular tool designed to mate with the group anchor system. Each module including drive mechanism for engaging and driving a pile. The piles may be driven simultaneously, individually, or in groups as required for proper placement and leveling. Methods of using the installation tool are also disclosed.

Abstract: Systems and methods for implementing extensible attributes in ETL are disclosed. In some examples, attributes configured at a source file may be extracted from the source file. The extracted attributes can be mapped to a target column of a data warehouse table, and then a dynamic ETL script may be generated. The dynamic script may be executed to move data associated with the attributes to an appropriate new column of the data warehouse.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: An electrochemical sensor incorporates a ferrocenophane which is a compound with at least one bridging group covalently attached to and connecting the two cyclopentadiene rings associated with the same iron atom. This bridging group maybe tetramethylene. As compared to an equivalent sensor with ferrocene, the tolerance of elevated temperature is improved and so is the working life at ambient temperature.

Abstract: Methods and systems for authenticating operations of an aircraft are disclosed. In at least one embodiment, the method may include: receiving, by an aircraft data gateway, a request for an operation of an aircraft from an operations portal; performing a first digital authentication of the request using first digital authentication information; performing a second digital authentication of the request using second digital authentication information, the second digital authentication information being distinct from the first digital authentication information; and executing the operation of the aircraft upon validating the first digital authentication and the second digital authentication.

Abstract: A system for providing integrated detection and deterrence against an unmanned vehicle including but not limited to aerial technology unmanned systems using a detection element, a tracking element, an identification element and an interdiction or deterrent element. Elements contain sensors that observe real time quantifiable data regarding the object of interest to create an assessment of risk or threat to a protected area of interest. This assessment may be based e.g., on data mining of internal and external data sources. The deterrent element selects from a variable menu of possible deterrent actions. Though designed for autonomous action, a Human in the Loop may override the automated system solutions.

Abstract: A method of determining a physical location for an address. The method includes receiving from a first global positioning system on a vehicle a first set of global positioning data indicative of a vehicle location. The method may also receive from a second global positioning system on a portable electronic device a second set of global positioning data indicative of a portable electronic device location. The method may also receive a set of location metadata associated with a picture. The method determines a residence location from the first set of global positioning data, the second set of global positioning data, or the set of location metadata. The method then associates the physical location to the address.

Abstract: The present invention relates to a sterilized packaging kit having surgical components used in a combined laparoscopic port closure procedure and targeted nerve block delivery that can both be performed by a surgeon. The specialized kit allows the surgeon to perform both a pre-op or post op nerve block and port closure.

Abstract: An orthopaedic prosthesis is disclosed. The orthopaedic prosthesis includes a frame including a plurality of beams defining an open-cell structure and a shell applied to the frame. The frame includes a proximal arm, a distal arm, and a central body connecting the proximal arm to the distal arm. The shell extends over the proximal arm, the distal arm, and the central body of the frame. A method of implanting an orthopaedic prosthesis is also disclosed.

Abstract: Light emitting structures and methods of fabrication are described. In an embodiment, LED coupons are transferred to a carrier substrate and then patterned to LED mesa structures. Patterning may be performed on heterogeneous groups of LED coupons with a common mask set. The LED mesa structure are then transferred in bulk to a display substrate. In an embodiment, a light emitting structure includes an arrangement of LEDs with different thickness, and corresponding bottom contacts with different thicknesses bonded to a display substrate.