Abstract: The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.

Abstract: A surgical robotic system includes a control tower and a mobile cart. The control tower is configured to selectively output power and includes a frequency generator and a converter. The frequency generator is configured to generate an electrical frequency signal and the converter is configured to receive the electrical frequency signal and convert the electrical frequency signal to a first optical signal having a unique identifier frequency. The mobile cart is configured to receive the first optical signal from the control tower and includes an optical splice configured to loop the first optical signal back to the control tower as a second optical signal and deliver the first optical signal to a frequency monitor of the mobile cart.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for using a continuous conveyor belt. One of the systems includes a conveyor belt adapted to move a plurality of comestibles and having i) a first edge, ii) a second edge opposite the first edge, iii) a first row of apertures that is substantially parallel to the first edge, and iv) a second row of apertures that is substantially parallel to the second edge.

Abstract: The present invention relates to compositions or vaccines for combating Mycoplasma hyopneumoniae (M hyo), Porcine Circovirus type 2 (PCV2), and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections in animals and for increasing the ability of pigs to gain weight and/or improve death loss, methods of vaccination against the infections, and kits for use with such methods and compositions.

Abstract: Systems and methods for changing programs on imaging devices are disclosed herein. An example method includes capturing, by a first imaging device, an image of a target object, and transmitting the image of the target object to a leader device that is communicatively coupled to the first imaging device and a second imaging device. The second imaging device may be different from the first imaging device. The example method may further include analyzing, by the leader device, the image of the target object using a photogrammetric technique to determine a dimension of the target object, and changing a program executing on the second imaging device based on the dimension of the target object.

Abstract: The invention provides novel benzamides of pyrazolyl-amino-pyrimidinyl derivatives of Formula (I) as selective and potent JAK inhibitors for treating various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: The present disclosure provides compounds of the formula: where R1, R2, R3, R4, R5, A, and B are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.

Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

Abstract: A system and method for automatically updating biometric data for a user by preferably retaining an ongoing digital collection of images/biometric captures/IOT (“Internet of Things”) captures taken over the life of the user. Changes in appearance of the user due to age, health, facial hair, hair color, hair length and many other evolutionary changes are automatically captured and contribute to the learning set. Accordingly, the system itself gets smarter and faster with every subsequent authentication. In one non-limiting embodiment, a target of the most recent 500 captures are retained, and tuning may suggest a greater number of captures should or could be used. Preferably, with each new capture the oldest capture in the ongoing digital collection is automatically deleted by the system.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: A containment apparatus for collecting electrolyte from a battery relief vent is provided. The containment apparatus includes a body comprising a reservoir, a relief vent aperture, an internal baffle, and an upper vent aperture; a push-on connection that attaches the relief vent aperture to the battery relief vent; and a viewing window on an external side of the body. The containment apparatus attaches to a pressure relief vent on a battery to capture droplets of electrolyte that are released from the battery relief vent. Liquid electrolytes travel through the relief vent aperture and into the reservoir, and vaporized electrolyte condenses on the baffle and falls into the reservoir as droplets or travels past the baffle and is directed through the upper vent aperture via the walls. The device prevents electrolytes from accumulating on the outside of the battery and associated hardware within the vicinity of the battery.

Abstract: A monitoring device for measuring organic compounds may include a housing of the monitoring device. The housing may be defined by an outer peripheral wall. The outer peripheral wall may include at least a first surface and a second surface opposite the first surface. The monitoring device may further include an interior cavity disposed within the housing. The monitoring device may further include a fan disposed within the interior cavity. The monitoring device may further include a plurality of slots in the first surface. The plurality of slots may be disposed directly above the fan and may be configured to allow the fan to pull ambient air from an environment outside of the housing into the interior cavity. The monitoring device may further include a visual indicator disposed on the first surface. The monitoring device may further include one or more buttons disposed on the first surface.

Abstract: Disclosed herein are styrene butadiene rubber latex compositions with high solids content and methods for making and using these compositions. The method for making the styrene butadiene rubber latex compositions can include mixing a seed, a styrene, an initiator, a base, a surfactant, and a solvent; adding a first portion of 1,3-butadiene to make a first reaction mixture; heating the first reaction mixture for a first reaction time to make a first styrene butadiene rubber latex; mixing the first styrene butadiene rubber latex, a styrene, a base, an initiator, a surfactant, and a solvent; adding a second portion of 1,3-butadiene to make a second reaction mixture; and heating the second reaction mixture for a second reaction time to make a second styrene butadiene rubber latex, where the second styrene butadiene rubber latex has a solids content higher than that of the first styrene butadiene rubber latex.

Abstract: A method performed by a first microservice processor includes receiving a first user indication from a first computing device from a plurality of computing devices of a second user that indicates that a first user requested a service of the second user. A first user-specific data container object is generated that includes first user-specific data elements associated with the service provided to the first user. First user-specific service-necessity information data objects are obtained from electronic resources. The first user-specific data elements and the first user-specific service-necessity information data objects are inputted into a machine learning engine to obtain ranked reference-claim data objects. A chosen reference-claim data object from the ranked reference-claim data objects is chosen by the second user to justify providing the service to the first user.

Abstract: Certain exemplary aspects of the present disclosure are directed towards an apparatus for electrostatic fluid filtration. The apparatus utilizing alternating positive and negative electrodes in conjunction with filter media there between to filter contaminants from a fluid flow.

Abstract: A replacement heart valve prosthesis for transcatheter repair of a native valve, the replacement heart valve comprises a valve construct mounted to the exterior surface of an expandable frame. The frame comprises an expandable region near the distal end of the frame, and a cusp region near the proximal region comprising a plurality of valve attachment features. The valve construct may be attached to the valve construct at least at the valve attachment features. The replacement heart valve prosthesis of present disclosure may be a more durable and long-lasting valve that has added benefits by placing valve tissue between the expandable frame and native cardiac tissue.

Abstract: A centralized application management computing system is described that is configured to generate digital dog tag files for local storage on each computing device of a plurality of computing devices (e.g., data center servers) within the enterprise network. The computing system is configured to periodically retrieve, from one or more sources within the enterprise network, application information for one or more applications hosted on a given computing device of the plurality of computing devices. The computing system is configured to periodically generate, based on the application information, a digital dog tag file for the given computing device that includes recovery information for the one or more applications hosted on the given computing device. The computing system is further configured to send the digital dog tag file for local storage at a predefined location on the given computing device.

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

Abstract: Read Fused Groups with uniform resource allocation. In one example, a data storage device including an electronic processor that, when executing the Uniform Read Fused Group scheme, is configured to receive information indicating each zone of a plurality of Zone Namespace (ZNS) zones is assigned to one of a plurality of Read Fused Groups (RFGs), assign a portion of a plurality of resources of a memory to the plurality of ZNS zones, control all of the plurality of concurrency units to process a first resource of the plurality of resources assigned to a first Read Fused Group (RFG) of the plurality of RFGs. The first resource is assigned to a first zone of the plurality of ZNS zones, the first zone is assigned to the first RFG, and the electronic processor is one of the plurality concurrency units.

Abstract: A remote vehicle control system includes a vehicle mounted sensor system including a video camera system for producing video data and a distance mapping sensor system for producing distance map data. A data handling system is used to compress and transmit both the video and distance map data over a cellular network using feed forward correction. A virtual control system acts to receive the video and distance map data, while providing a user with a live video stream supported by distance map data. Based on user actions, control instructions can be sent to the vehicle mounted sensor system and the remote vehicle over the cellular network.