Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.

Abstract: A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

Abstract: A computer-implemented method of assessing roughness in metallic lines of an integrated circuit (IC) is provided. The computer-implemented method includes developing a library of roughness characterizations for metal lines of varying characteristics and dimensions. The computer-implemented method further includes fabricating a testable IC and identifying, in the testable IC, a location of interest (LoI) at which roughness of a metal line within the LoI could impact IC performance. Also, the computer-implemented method includes developing, from the library, a roughness model using the roughness characterizations for those metal lines having characteristics and dimensions corresponding to those of the metal line within the LoI and refining the library and the roughness model based on a comparison of the roughness model and an actual roughness of the metal line within the LoI to obtain a final roughness model.

Abstract: An apparatus for vertical transfer of whole nuts from a first elevation to a second, lower elevation includes a run extending between an entrance and an exit, and having a plurality of alternatingly arranged conveying panels between the entrance and the exit. Each conveying panel is inclined at approximately 30 degrees to horizontal and has a variable effective conveying width. The apparatus further includes arcuate turn-arounds disposed between respective conveying panels to facilitate transferring the nuts from one conveying panel to the next lower conveying panel. The variable effective conveying width is selected based on a predetermined mass flow rate of nuts such that whole nuts move along the run in a continuous stream without tumbling, and wherein each nut is in contact with adjacent nuts in its respective layer.

Abstract: A low earth orbit (LEO) satellite including a processor, a memory, and a communication sub-system. The communication sub-system including: an antenna array and a reconfigurable digital logic processing device. The processor dynamically reconfigures the reconfigurable digital logic processing device to amplify or attenuate transmissions received from one or more directions of interest, or to amplify or attenuate signals transmitted by the antenna array in one or more directions of interest according to the orbital schedule of the LEO satellite.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.

Abstract: Methods and apparatus for utilizing a valve with a pump rotor passage with a downhole production string, the pump rotor being on a rotatable rod with a bobbin moving along the rod between a position for opening the passage to fluid flow, when the bobbin is not seated on a shuttle seat, and a position for closing the passage to fluid flow, when the bobbin is seated on the shuttle seat. The pump rotor and rod are removable through the passage while leaving the pump stator in place upstream of the valve.

Abstract: Optical hyperfocal reflective systems and methods are provided. One such optical hyperfocal reflective system has an optical substrate; an optical input coupling portion configured to input couple a collimated display image to the optical substrate; and an optical hyperfocal output coupling portion integrated with said optical substrate. The optical output coupling portion includes at least one hyperfocal reflective view port formed from a discrete optical hyperfocal reflector spot integrated with the optical substrate. The discrete optical hyperfocal reflector spot is sized to form a reflected discrete optical spot beam with a diameter at a target area such that a view of a discrete virtual display image portion, as seen by a lens-detector system locatable at the target area, is hyperfocused.

Abstract: A square gauge apparatus configured for being selectively and removably mounted on a leg of a carpenter's square has a ledge having a ledge first surface and an opposite ledge second surface, the ledge first and second surfaces being parallel and offset, a first abutment extending from the ledge and having a first abutment front surface that is perpendicular to the ledge first surface, a second abutment extending from the ledge opposite the first abutment and having a second abutment front surface that is perpendicular to the ledge second surface and parallel to and coplanar with the first abutment front surface, and a slot formed adjacent to the ledge between the first and second abutments, the slot having a slot end surface that is parallel to and coplanar with the first and second abutment front surfaces.

Abstract: A tip including an alloy of platinum and an alloying element chosen from gold, palladium, ruthenium, osmium, iron, cobalt, nickel, copper, zinc, silver, chromium, manganese, titanium, niobium, scandium, vanadium, yttrium, zirconium, molybdenum, tantalum, tungsten, technetium, cadmium, hafnium, rhenium, less than 5 wt. % of iridium, less than 5 wt. % of rhodium, greater than 20 wt. % iridium, greater than 20 wt. % rhodium, and a combination thereof, relative to the total weight of the alloy is disclosed. An interface cone can include a base and the tip.

Abstract: A surgical tool includes a drive housing, a shaft extending from the drive housing, an end effector at an end of the shaft and having opposing jaws and a cutting element, and an articulable wrist configured to rotate the end effector within a plane. The wrist is articulated via antagonistic translation of a pair of drive members. Various systems are provided for homing one or more drive inputs that cause movement in the wrist and/or the end effector, or for controlling articulation of the drive inputs.

Abstract: A method of forming a structure for etch masking that includes forming first dielectric spacers on sidewalls of a plurality of mandrel structures and forming non-mandrel structures in space between adjacent first dielectric spacers. Second dielectric spacers are formed on sidewalls of an etch mask having a window that exposes a connecting portion of a centralized first dielectric spacer. The connecting portion of the centralized first dielectric spacer is removed. The mandrel structures and non-mandrel structures are removed selectively to the first dielectric spacers to provide an etch mask. The connecting portion removed from the centralized first dielectric spacer provides an opening connecting a first trench corresponding to the mandrel structures and a second trench corresponding to the non-mandrel structures.

Abstract: A method of randomizing inductor current in at least one of a plurality of parallel coupled peak/valley current-controlled power converters may include comparing the inductor current to a threshold to generate a comparison signal, delaying the comparison signal by a plurality of delay amounts to generate a plurality of delayed versions of the comparison signal, and randomly selecting one of the plurality of delayed versions of the comparison signal for controlling the inductor current during one or both of a charging state and a transfer state of the at least one of the plurality of parallel coupled peak/valley current-controlled power converters.

Abstract: The various examples are directed to establishing a secure session between a device and a server. The device and the server may establish a session key. The session key may be used for encrypting data. After authenticating the session key, the server may transmit secure session data to the device, and the device may store the secure session data. The server may transmit information for deriving, based on secure session data, the session key to a different server. The device may transmit the secure session data to the server, or to the different server, to re-establish the secure session. The different server may derive, using the information and based on the secure session data, the session key. The different server may re-establish, using the session key, the secure session.

Abstract: System and computer-implemented method of analyzing tags associated with a sequence of images presented to a user to present a current interest of the user is disclosed. An image from among a plurality of images is presented on an electronic display. The image is associated with a set of tags. An input is received indicating a user's preference for the image. A plurality of tags is processed based on the preference and the set of tags to determine a next set of tags from the plurality of tags. A next image is determined from the plurality of images based on the next set of tags. The next image represents a physical object, different from a physical object represented by the previous image. A sequence of images is generated by repeating the above process with the next image in place of the previous image for present a user's current interest.

Abstract: A memory using mixed valence conductive oxides is disclosed. The memory includes a mixed valence conductive oxide that is less conductive in its oxygen deficient state and a mixed electronic ionic conductor that is an electrolyte to oxygen and promotes an electric filed to cause oxygen ionic motion.

Abstract: A method for fabricating patterns on a flexible substrate in a roll-to-roll configuration. Drops of a monomer diluted in a solvent are dispensed on a substrate, where the drops spontaneously spread and merge with one another to form a liquid resist formulation. The solvent is evaporated (e.g., blanket evaporation) from the liquid resist formulation followed by selective multi-component resist film evaporation resulting in a non-uniform and substantially continuous film on the substrate. The gap between the film on the substrate and a template is closed such that the film fills the features of the template. After cross-linking the film to polymerize the film, the template is separated from the substrate thereby leaving the polymerized film on the substrate.

Abstract: A system for configuring an information handling system based on a multi-user state change. An intelligent sensor hub communicates with sensors to detect the number of persons in a field of view of the information handling system. When the intelligent sensor hub determines there is a change in the number of persons, the information is sent out-of-band to an embedded controller (EC) independent of a host operating system. The EC makes a change to the configuration of the information handling system if needed.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.