Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: An expansible ear canal insert for treating TMJ disorders and headaches which acts directly on the TMJ and associated ligament and muscle structures to reduce stress and loads placed on the articulator disc located between the temporal bone and the mandible, as well as supportive muscles and ligaments near the TMJ. The insert is adapted to expand by application of body heat. In the expanded condition, the insert provides support to the TMJ and associated ligament and muscle structures.

Abstract: Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.

Abstract: Disclosed is a dishwasher having an interior with a tub, a dish rack slidably attached to the tub, the dish rack having a plurality of vertically-oriented side rails, and a height adjustment system including first and second height adjustment mechanisms provided alongside walls of the dish rack for vertically shifting the dish rack between lowered and raised positions relative to the tub. Each of first and second height adjustment mechanisms includes an adjuster arm fixed vertically relative to the tub, having at least one locking boss at the first end, and a locking clip on the adjuster arm having at least one locking tab adapted to couple with the locking boss to prevent the rack from shifting vertically relative to the adjuster arm. The locking clip has a pair of interference ribs engaging a pair of side rails to prevent rotational movement of the rack with respect to the dishwasher.

Abstract: A cartridge drive gear assembly for holding a drum coupling includes a drive gear having an outer surface and an inner surface, the inner surface including inner projections which extend into the interior of the drive gear and includes at least two voids disposed on opposing sides of the inner projections, and at least one slot disposed in the inner surface.

Abstract: Method of building a grid system wherein a plurality of modular apparatuses can be arranged at a structure site. The plurality modular apparatuses can have a central tubular member having an inner bore formed between a proximal end and a distal end, and a plurality of vanes having a lateral width at least equal to a diameter of the central tubular member. The one or more modular apparatuses can be positioned above a surface of the structure site. Each of the plurality modular apparatuses can be connected with at least two adjacent modular apparatuses of the plurality of modular apparatuses via a locking lug on one of the plurality of vanes slidingly engaged with a locking channel on an adjacent modular apparatus. The plurality of modular apparatuses can then be driven into the structure site wherein the inner bore receives earthen formation therein.

Abstract: A method of forming magnetic device structures and electrical contacts, including removing a portion of a second interlayer dielectric (ILD) layer to expose an underlying portion of a cap layer in a first device region, wherein the cap layer is on a first ILD layer, while leaving an ILD block in a second device region, forming a spacer layer on the exposed portion of the cap layer in the first device region, forming an electrical contact layer on the spacer layer in the first device region, forming a magnetic device layer on the electrical contact layer and ILD block, removing portions of the magnetic device layer to form a magnetic device stack on the ILD block, and removing portions of the electrical contact layer to form electrical contact pillars, wherein the portions of the electrical contact layer and portions of the magnetic device layer are removed at the same time.

Abstract: A patient monitoring system receives time series matrices, detects perturbations, extracts a set of features of the perturbations. The system also converts each perturbation into at least one object, links the features of each perturbation with the object into which the perturbation was converted, and formats the objects and the features into a time series of feature linked objects. The system includes an image recognizer programmed to receive the time series of feature linked objects, and detect an image comprised of at least three objects in timed relation to each other to generate an output indicative of the potential presence of the target condition in response to the detection of the image.

Abstract: There is provided a centrifugal pump comprising a pumping chamber (106). The pumping chamber (106) has an inner surface (108) defining a pump cavity (110); a pump inlet (112) defined in a first side of the pumping chamber (106); a shaft opening (116) defined substantially centrally in a second side of the pumping chamber (106), the second side substantially opposing the first side and arranged to be above the first side, in use; and a pump outlet (114). The centrifugal pump further comprises an impeller (120) retained within the pump cavity (110); and a shaft member (140) mechanically connected to the impeller (120) through the shaft opening (116), whereby rotation of the shaft member (140) causes rotation of the impeller (120) about a shaft axis (157) passing through the shaft opening (116) and movement of a pumping liquid from the pump inlet (112) towards the pump outlet (114).

Abstract: Provided herein are methods for detecting and identifying strains of mycobacteria, and compositions and kits for performing such methods. In particular, nucleic acid amplification and fluorescence detection methods are provided for the detection and differentiation of mycobacteria based on, for example, pathogenicity, species, and antibiotic resistance or sensitivity. Compositions and methods are provided herein to identify and differentiate mycobacteria in mixtures of different mycobacteria and mycobacteria and non-mycobacteria.

Abstract: Sulfur-containing polymeric particles having a high sulfur content can be prepared using emulsion polymerization. The sulfur-containing polymeric particles are useful in aerospace coatings and sealants.

Abstract: A method of cleaning power cells in an array of power cells, comprising coupling at least one first power cell to second power cells in an array of power cells and causing the second power cells to drive the at least one first power cell with a voltage to clean catalyst on the at least one first power cell.

Abstract: A guidewire for use with ureteral stents has an elongated shape with a proximal end and a distal end. The guidewire has indicia along the proximal end to indicate the length of the guidewire that was introduced into the patient. Based on the indicia or the visual inspection, a physician can select the appropriately sized stent to place in the patient.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.

Abstract: A low profile pump motor lead protector with a head guard and a trailing guard, the head guard including a front section with a front end and a rear section with a rear end, the trailing guard having a pin end for insertion in a head guard socket, the lead protector for protecting a motor lead of a pump and motor assembly of a downhole production string for surfacing fluid from a reservoir such as a subterranean oil well.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to ?v-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ?v-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Abstract: A system and method for automatically and remotely adjusting the position of a captive beam is provided. The system includes a motor that moves a bracket along a vertical track, with the bracket supporting an end of the captive beam. The bracket rotatably supports a latch that engages an aperture in a track when aligned therewith to allow track to support the load of the captive beam and the load supported by the captive beam.

Abstract: Technical solutions are described herein for adjusting a notification system of a vehicle. An example method includes receiving, by a controller, an occupant profile of an occupant of the vehicle. The method further includes adjusting, by the controller, a haptic array according to the occupant profile, the haptic array comprising a plurality of haptic actuators, the adjusting comprising activating a first subset of the haptic actuators and deactivating a second subset of the haptic actuators. Further, the method includes providing, by the haptic array, a notification to the occupant of the vehicle by providing a haptic feedback using the activated haptic actuators.

Abstract: An unducted thrust producing system is provided that can include a rotating element having an axis of rotation about a central longitudinal axis and comprising a plurality of blades attached to a spinner; a stationary element positioned aft of the rotating element; and an inlet positioned between the rotating element and the stationary element such that the inlet passes radially inward of the stationary element. The rotating element defines an annular valley positioned between a first annular crown and a second annular crown, and the inlet defines an open area positioned aft of the second annular crown.

Abstract: Described are techniques for enabling pointer devices to be used by users with vision impairment to interact with rendered content. Sounds may be output to a user to indicate the presence of one or more features within rendered content. Characteristics of the sounds may be used to indicate the position of the features within a user interface, the distance between the features and a pointer associated with a pointer device, and the direction of the features relative to the pointer. Sounds may also be used to indicate the type or size of rendered content. Responsive to the sounds, a user with impaired vision may manipulate the pointer device to reposition the pointer. Additional or modified sounds may be provided to the user based on the subsequent position of the pointer.