Abstract: Genetically modified pigs having at least one cancer and/or at least one co-morbid condition are provided. Also provided are methods of using the pig and derived tumor cells to screen for therapeutic compounds, medical devices or procedures, and/or combinations thereof. Further provided are methods of producing personalized cancer models, including obtaining a tumor sample from a subject, identifying mutations in the tumor sample, and producing a genetically modified tumor or tumor cell line having the same mutations.

Abstract: Acetylated low density lipoproteins are combined with active and effective lipophilic peptide or other lipophilic immunomodulators, antigens or vaccines to carry the same to macrophage specific targeted receptor mediated endocytosis sites in a living system for treatment of cancer, infection hyperimmune related diseases or deficiences, or to enhance vaccine induction of immunity. Such receptor mediated endocytosis sites are found on macrophages, monocytes and endothelial cells in organs and tissues of the body.The combination of acetyl-LDL and a lipophilic peptide or related lipophilic immunomodulators, antigens, polynucleotides or vaccines enables delivery of such to be made across vascular barriers by transcytosis. The penetration of endothelial blood-brain, eye or testicular barriers is included in this concept.