Patents by Inventor Lawrence Barak

Lawrence Barak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule agonists of neurotensin receptor 1
    Patent number: 9868707
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: January 16, 2018
    Assignees: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, DUKE UNIVERSITY
    Inventors: Anthony Pinkerton, Patrick Maloney, Paul Hershberger, Satyamaheshwar Peddibhotla, Michael Hedrick, Lawrence Barak, Marc Caron
  • SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1
    Publication number: 20150329497
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: December 19, 2013
    Publication date: November 19, 2015
    Applicant: DUKE UNIVERSITY
    Inventors: Anthony PINKERTON, Patrick MALONEY, Paul HERSHBERGER, Satyamaheshwar PEDDIBHOTLA, Michael HEDRICK, Lawrence BARAK, Marc CARON
  • SMOOTHENED RECEPTOR MODULATORS
    Publication number: 20120094974
    Abstract: The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: June 16, 2009
    Publication date: April 19, 2012
    Inventors: Wei Chen, Lawrence Barak, H. Kim Lyerly, Jiangbo Wang
  • METHODS OF ASSAYING RECEPTOR ACTIVITY
    Publication number: 20060188944
    Abstract: Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process.
    Type: Application
    Filed: May 9, 2002
    Publication date: August 24, 2006
    Inventors: Lawrence Barak, Marc Caron, Stephen Ferguson, Jie Zhang
  • Modified G-protein coupled receptors
    Publication number: 20050106623
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRS.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 19, 2005
    Inventors: Robert Oakley, Lawrence Barak, Stephane Laporte, Marc Caron