Abstract: A micro-cantilever includes a base, a micro-cantilever beam and a tip. The micro-cantilever beam extends outwardly from the base and is constructed from a material including a thermoplastic polymer material. The micro-cantilever beam has a distal end opposite the base. The tip extends transversely from the distal end. The tip is constructed from a material including a thermoplastic polymer material and is integrated with the micro-cantilever beam. To make a micro-cantilever, a mold defining a cavity having a geometry of a micro-cantilever is formed and an indentation corresponding to an image of a probe tip is formed in the mold. Molten thermoplastic is injected into the mold.

Abstract: A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell receives a different sample fluid. A plurality of microcantilevers may be disposed in each of the interaction cells, wherein each of the plurality of microcantilevers configured to deflect in response to an interaction involving a component of the sample fluid.