Abstract: A foldable bed includes a first outer panel defining a length and a width, a middle panel hingedly coupled to the first outer panel along an inner edge of the first outer panel, the middle panel defining a length and a width, the middle panel defining a cut-out having a length and a width, and a second outer panel hingedly coupled to the middle panel opposite the first outer panel and along an inner edge of the second outer panel, the second outer panel defining a length and a width. Each of the first outer panel, the middle panel, and the second outer panel includes a rigid substrate with a cushion coupled thereto, and the panels are hingedly coupled by a webbing extending across a lower surface of the foldable bed.

Abstract: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.