Patents by Inventor Lawrence C. Paoletti

Lawrence C. Paoletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid
    Patent number: 7534442
    Abstract: The present invention is directed to immunogenic conjugates comprised of a polymer, preferably a polysaccharide, with a covalently attached antigen and an agent for boosting a patient's immune response. The conjugates may be used in vaccines for a wide range of diseases.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: May 19, 2009
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Lawrence C. Paoletti
  • System for co-culturing bacteria and eukaryotic cells
    Publication number: 20040132126
    Abstract: The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and then perfused over the eukaryotic cells. The invention also includes a variety of methods for studying the attachment and invasion of host eukaryotic cells by bacteria.
    Type: Application
    Filed: September 29, 2003
    Publication date: July 8, 2004
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Lawrence C. Paoletti, Gennady Malin
  • System for co-culturing bacteria and eukaryotic cells
    Patent number: 6696287
    Abstract: The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and then perfused over the eukaryotic cells. The invention also includes a variety of methods for studying the attachment and invasion of host eukaryotic cells by bacteria.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: February 24, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Lawrence C. Paoletti, Gennady Malin
  • Conjugate vaccines
    Publication number: 20030170267
    Abstract: The present invention is directed to immunogenic conjugates comprised of a polymer, preferably a polysaccharide, with a covalently attached antigen and an agent for boosting a patient's immune response. The conjugates may be used in vaccines for a wide range of diseases.
    Type: Application
    Filed: August 20, 2002
    Publication date: September 11, 2003
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventor: Lawrence C. Paoletti
  • System for co-culturing bacteria and eukaryotic cells
    Publication number: 20020146808
    Abstract: The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and then perfused over the eukaryotic cells. The invention also includes a variety of methods for studying the attachment and invasion of host eukaryotic cells by bacteria.
    Type: Application
    Filed: March 19, 2002
    Publication date: October 10, 2002
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Lawrence C. Paoletti, Gennady Malin