Patents by Inventor Lawrence D. Wise

Lawrence D. Wise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzoxazinone dopamine D4 receptor antagonists
    Patent number: 6177422
    Abstract: This invention relates to compounds that are antagonists of dopamine D4 receptors, to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors, and to pharmaceutically acceptable compositions that contain a dopamine D4 receptor antagonist.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 23, 2001
    Assignee: Warner-Lambert Company
    Inventors: Thomas R. Belliotti, Lawrence D. Wise, David J. Wustrow
  • Substituted piperazines and piperidines as central nervous system agents
    Patent number: 6121267
    Abstract: Di- and tri-Methoxybenzyl substituted piperazines and piperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopamine antagonists and antipsychotic agents.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: September 19, 2000
    Assignee: Warner-Lambert Company
    Inventors: Shelly A. Glase, Terri S. Purchase, Lawrence D. Wise
  • Substituted piperazines and piperidines as central nervous system agents
    Patent number: 5965560
    Abstract: Substituted piperazines and piperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopamine antagonists and antipsychotic agents.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: October 12, 1999
    Assignee: Warner-Lambert Company
    Inventors: Shelly A. Glase, Terri S. Purchase, Lawrence D. Wise
  • Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX
    Patent number: 5929064
    Abstract: Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as antiobesity agents and for the treatment of cyanide poisoning, neonatal hyperbilirubinemia, and cancer.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: July 27, 1999
    Assignee: Warner-Lambert Company
    Inventors: Om P. Goel, Stephen J. Johnson, Lawrence D. Wise
  • Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
    Patent number: 5620988
    Abstract: Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Benzimidazoles and imidazopyridines as central nervous system agents
    Patent number: 5486517
    Abstract: Benzimidazoles and imidazopyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and for the treatment of disorders which respond to dopaminergic blockade including psychotis depression, substance abuse, and compulsive disorders.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: January 23, 1996
    Assignee: Warner-Lambert Company
    Inventors: Dennis M. Downing, Shelly A. Glase, Stephen J. Johnson, Lawrence D. Wise, Jonathan L. Wright
  • Substituted tetrahydrophyridines and hydroxypiperidines as central nervous system agents
    Patent number: 5466698
    Abstract: Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: November 14, 1995
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Neurotensin antagonists
    Patent number: 5430047
    Abstract: Neurotensin antagonists are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and as agents to treat Parkinson's disease and gastrointestinal disorders.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: July 4, 1995
    Assignee: Warner-Lambert Company
    Inventors: Stephen J. Johnson, Suzanne R. Kesten, Lawrence D. Wise, David J. Wustrow
  • Dimeric benzimidazoles as central nervous system agents
    Patent number: 5414010
    Abstract: Dimeric benzimidazoles are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and for the treatment of disorders which respond to dopaminergic blockade including psychotic depression, substance abuse, and compulsive disorders.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: May 9, 1995
    Assignee: Warner-Lambert Company
    Inventors: Dennis M. Downing, Lawrence D. Wise, Jonathan L. Wright
  • 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
    Patent number: 5409931
    Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: April 25, 1995
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
  • Neurotensin mimetics as central nervous system agents
    Patent number: 5407916
    Abstract: Neurotensin mimetics are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as analgesic and antipsychotic agents.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: April 18, 1995
    Assignee: Warner-Lambert Company
    Inventors: Lawrence D. Wise, David J. Wustrow
  • Naphthalamides as central nervous system agents
    Patent number: 5395835
    Abstract: Naphthalamides are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and as agents for the treatment of disorders which respond to dopaminergic blockade including psychotic depression, substance abuse, and compulsive disorders.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: March 7, 1995
    Assignee: Warner-Lambert Company
    Inventors: Shelly A. Glase, Suzanne R. Kesten, Lawrence D. Wise, Jonathan Wright
  • 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
    Patent number: 5314896
    Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: May 24, 1994
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
  • Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
    Patent number: 5273977
    Abstract: Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: December 28, 1993
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted piperazines as central nervous system agents
    Patent number: 5270312
    Abstract: Substituted piperazines and derivatives of Formula I ##STR1## are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: December 14, 1993
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted thiazepines as central nervous system agents
    Patent number: 5206233
    Abstract: Substituted thiazepines are described as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic and antidepressant agents as well as for treating cerebral ischemia or cerebral infarction.
    Type: Grant
    Filed: August 27, 1991
    Date of Patent: April 27, 1993
    Assignee: Warner-Lambert Company
    Inventors: William J. Smith, III, Lawrence D. Wise, David J. Wustrow
  • Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents
    Patent number: 5198443
    Abstract: Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: March 30, 1993
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Substituted tetrahydropyridines and their use as central nervous system agents
    Patent number: 5187280
    Abstract: Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: August 16, 1991
    Date of Patent: February 16, 1993
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, David G. Nickell, Donna M. Reynolds, Sarah J. Smith, Lawrence D. Wise, David J. Wustrow
  • Substituted indoles as central nervous system agents
    Patent number: 5124332
    Abstract: Substituted indoles and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: June 23, 1992
    Assignee: Warner-Lambert Company
    Inventors: Lawrence D. Wise, David J. Wurtrow
  • Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents
    Patent number: 5120748
    Abstract: Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: June 9, 1992
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise