Abstract: Apparatus and related methods for assisting tool use includes one or more motors, a wrist support and a shaft coupled to the one or more motors. The shaft includes a coupling to couple to a tool to enable a user resting a hand with the wrist on the wrist support to hold and manipulate the tool with one or more fingers. The apparatus can include a controller configured to: receive position data indicative of a position of an active end of the tool; receive constraint data indicative of one or more regions of space in which the active end should not be positioned; and process the position and constraint data to control the one or more motors to bias the active end out of a region indicated by the constraint data when a position indicated by the position data is within the region indicated by the constraint data.

Abstract: Apparatus and related methods for assisting tool use includes one or more motors, a wrist support and a shaft coupled to the one or more motors. The shaft includes a coupling to couple to a tool to enable a user resting a hand with the wrist on the wrist support to hold and manipulate the tool with one or more fingers. The apparatus can include a controller configured to: receive position data indicative of a position of an active end of the tool; receive constraint data indicative of one or more regions of space in which the active end should not be positioned; and process the position and constraint data to control the one or more motors to bias the active end out of a region indicated by the constraint data when a position indicated by the position data is within the region indicated by the constraint data.

Abstract: The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5 b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., B-RAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and conditions that are ameliorated by the inhibition of RAF, RTK, etc., proliferative conditions such as cancer (e.g., colorectal cancer, melanoma), etc.

Abstract: The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5 b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc.

Abstract: A device for measuring the mass rate of flow which operates according to the Coriolis principle, with a measurement tube (1) and a magnet coil (7) of a bobbin (9) and a winding (10) attached to it for exciting and/or detecting vibrations of the measurement tube (1). The bobbin (9) of the magnet coil (7) has a specific thermal conductivity of at least 1 W/(K m). This enables the heat which forms in the magnet coil (7) to be efficiently dissipated to the surrounding vicinity without cooling elements, such as cooling fins, being necessary. In this way, the efficiency of the device for measuring the mass rate of flow using the Coriolis principle is altogether improved.

Abstract: A device for measuring the mass rate of flow which operates according to the Coriolis principle, with a measurement tube (1) and a magnet coil (7) of a bobbin (9) and a winding (10) attached to it for exciting and/or detecting vibrations of the measurement tube (1). The bobbin (9) of the magnet coil (7) has a specific thermal conductivity of at least 1 W/(K m). This enables the heat which forms in the magnet coil (7) to be efficiently dissipated to the surrounding vicinity without cooling elements, such as cooling fins, being necessary. In this way, the efficiency of the device for measuring the mass rate of flow using the Coriolis principle is altogether improved.

Abstract: An active-constraint robot (4), particularly for surgical use, is controlled by means of a series of motorized joints to provide a surgeon with real-time tactile feedback of an operation in progress. The robot system holds, in memory, a series of constraint surfaces beyond which it would be dangerous for the surgeon to go, and a resistive force is applied to the cutting tool (14) as the surgeon approaches any such surface. To improve the overall quality of feedback experienced by the surgeon, the resistive force applied to the cutting tool (14) depends upon the point of intersection (I) between the force factor applied by the surgeon and the surface. Further improvements are achieved by adjusting the tangential resistive force, when the tool is adjacent to the surface, in dependence upon the surrounding shape of the surface.

Abstract: A Coriolis mass flowmeter that incorporates a straight Coriolis measuring tube, two straight connecting pipes, at least one oscillator stimulating the tube, a measuring sensor associated with the tube and a compensating cylinder, where the tube is positioned within the cylinder, the two end sections of the cylinder are solidly connected to the respective end sections of the tube, the tube transitions with either end section into a connecting pipe, the connecting pipes extending outside the compensating cylinder, and by means of mounting flanges provided on the external ends of the connecting pipes, the mass flowmeter can be installed in a pipeline system. Each connecting pipe meets the requirements of the formula M ? ? ? f 2 e ? ? ? i / l 3 > 5.

Abstract: A Coriolis mass flowmeter that incorporates a straight Coriolis measuring tube, two straight connecting pipes, at least one oscillator stimulating the tube, a measuring sensor associated with the tube and a compensating cylinder, where the tube is positioned within the cylinder, the two end sections of the cylinder are solidly connected to the respective end sections of the tube, the tube transitions with either end section into a connecting pipe, the connecting pipes extending outside the compensating cylinder, and by means of mounting flanges provided on the external ends of the connecting pipes, the mass flowmeter can be installed in a pipeline system. Each connecting pipe meets the requirements of the formula 1 Mf   ⁢ 2 ei / l 3 > 5.

Abstract: An active-constraint robot (4), particularly for surgical use, is controlled by means of a series of motorised joints to provide a surgeon with real-time tactile feedback of an operation in progress. The robot system holds, in memory, a series of constraint surfaces beyond which it would be dangerous for the surgeon to go, and a resistive force is applied to the cutting tool (14) as the surgeon approaches any such surface. To improve the overall quality of feedback experienced by the surgeon, the resistive force applied to the cutting tool (14) depends upon the point of intersection (I) between the force factor applied by the surgeon and the surface. Further improvements are achieved by adjusting the tangential resistive force, when the tool is adjacent to the surface, in dependence upon the surrounding shape of the surface.

Abstract: A training system for training a user in the operation of a tool comprises a two-axis actively-constrained computer-controlled motorised table (1000) which has a grip member (2000) attached to a pen (3000). In use, the system provides active constraint to a user, allowing the pen (3000) to move only within a narrow region of permitted motion. As the user becomes more proficient, the system gradually allows the user more freedom. In that way, the user becomes more proficient in performing certain physical motions. The system finds particular although not exclusive applicable in the training of surgeons, specifically in surgical implant procedures.

Abstract: The invention in its various forms relates generally to surgical planning methods, and in particular to the planning of surgical operations to implant a prosthesis. In a first embodiment, the surgeon uses an interactive system to design both the shape of the prosthesis and the shape of the bone. In a second embodiment, a modified Marching Cubes algorithm is used to simulate cutting planes within bones. In a third embodiment, back-projection is used within a computer model to allow an integrated display of both bone and prosthesis. In a fourth embodiment, an interactive system is used to test the mobility of a proposed implant, prior to undertaking a surgical operation.

Abstract: A method for mounting a metal body on an essentially straight measuring tube, made of titanium or zirconium, of a Coriolis mass flowmeter. The method ensures secure retention of the metal body on the measuring tube even through very extended operation of the Coriolis mass flowmeter, in that the metal body is shrink-mounted on the measuring tube.

Abstract: A method for mounting a metal body on an essentially straight measuring tube, made of titanium or zirconium, of a Coriolis mass flowmeter. The method ensures secure retention of the metal body on the measuring tube even through very extended operation of the Coriolis mass flowmeter, in that the metal body is shrink-mounted on the measuring tube.

Abstract: Description and illustration of a method for mounting a metal body (1) on an essentially straight measuring tube (2), made of titanium or zirconium, of a Coriolis mass flowmeter. The method ensures secure retention of the metal body (1) on the measuring tube (2) even through very extended operation of the Coriolis mass flowmeter, in that the metal body (1) is shrink-mounted on the measuring tube (2).

Abstract: A mass flowmeter operating by the Coriolis principle incorporates a straight Coriolis measuring tube through which flows a fluid or medium, at least one oscillator associated with and exciting the Coriolis measuring tube, and at least one detector associated with the Coriolis measuring tube for capturing the Coriolis forces and/or the Coriolis-force-induced oscillations. To provide a Coriolis flowmeter incorporating a Coriolis measuring tube which is subject to only minimal thermal expansion and, accordingly, to only minimal thermal stress, and which is resistant to chemicals, the Coriolis measuring tube is made of a ceramic material.

Abstract: A mass flowmeter operating by the Coriolis principle and incorporating an essentially straight, moving-fluid-conducting Coriolis measuring tube, at least one oscillator associated with and exciting the Coriolis measuring tube, at least one detector associated with the Coriolis measuring tube and sensing the Coriolis forces and/or the Coriolis oscillations generated by Coriolis forces, and a compensating cylinder in which the Coriolis measuring tube is positioned, the Coriolis measuring tube and the compensating cylinder being connected to each other in which the oscillation-capable system composed of the Coriolis measuring tube and the compensating cylinder is at least to a large extent mass-equalized both for the excitation oscillation of the Coriolis measuring tube and for the Coriolis oscillation of the Coriolis measuring tube.

Abstract: A mass flowmeter operating by the Coriolis principle incorporates a straight Coriolis measuring tube through which flows a fluid or medium, at least one oscillator associated with and exciting the Coriolis measuring tube, and at least one detector associated with the Coriolis measuring tube for capturing the Coriolis forces and/or the Coriolis-force-induced oscillations. To provide a Coriolis flowmeter incorporating a Coriolis measuring tube which is subject to only minimal thermal expansion and, accordingly, to only minimal thermal stress, and which is resistant to chemicals, the Coriolis measuring tube is made of a ceramic material.

Abstract: An electrical discharge machining apparatus is disclosed having a frame with a base and a vertical support secured to and extending upwardly from the base. A tank adapted to contain an electrolytic liquid is secured to the vertical support by an adjustment mechanism which enables the vertical position of the tank to be varied. A work holder is optionally pivotally secured to the top of the vertical support and movable between a work position in which the work support and work are aligned with the tank and an inspection position in which the work holder is laterally spaced from the tank. Electrical discharge electrodes are contained within the tank while a servo motor vertically moves the work support with its attached work against the electrodes to perform the machining operation. The electrical discharge apparatus is particularly suited for dental prosthesis applications.