Patents by Inventor Lawrence DeLucas
Lawrence DeLucas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070281359Abstract: A method of screening solution conditions suitable for the crystallization of macromolecules with a picogram to a microgram of protein using picoliter or nanoliter volumes is provided. A preferred method comprises preparing a plurality of recipe solutions in milliliter volumes, aspirating protein and recipe solutions, respectively, from a plurality of wells, and dispensing the protein and recipe solutions into a plurality of wells, covering the combined protein and recipe solutions with oil, and maintaining the solution wells until crystallization or precipitation occur therein.Type: ApplicationFiled: March 21, 2007Publication date: December 6, 2007Inventors: Arnon Chait, Lawrence DeLucas, Brad Stoops, Alexander Belgovskiy
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Publication number: 20070202602Abstract: A method of screening protein crystal growth conditions with picogram to microgram amounts of protein in picoliter or nanoliter volumes is provided. A preferred method comprises a microarray with a plurality of microchambers in the microarray. A protein solution is placed into the micro-chambers by an automated dispensing mechanism. The protein crystal growth conditions of each of the micro-chambers is adjusted so that the protein crystal growth conditions in at least two of the micro-chambers differs. Crystallization of the protein solution in the micro-chambers is effected. For example, crystallization can be effected by a precipitate solution and/or placing an oil barrier over the protein solution. Protein crystal growth in the micro-chambers is then observed.Type: ApplicationFiled: December 15, 2006Publication date: August 30, 2007Inventors: Lawrence DeLucas, Terry Bray
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Patent number: 7244396Abstract: A method of screening solution conditions suitable for the crystallization of macromolecules with a picogram to a microgram of protein using picoliter or nanoliter volumes is provided. A preferred method comprises preparing a plurality of recipe solutions in milliliter volumes, aspirating protein and recipe solutions, respectively, from a plurality of wells, and dispensing the protein and recipe solutions into a plurality of wells, covering the combined protein and recipe solutions with oil, and maintaining the solution wells until crystallization or precipitation occur therein.Type: GrantFiled: October 23, 2002Date of Patent: July 17, 2007Assignee: UAB Research FoundationInventors: Arnon Chait, Lawrence DeLucas, Brad Stoops, Alexander Belgovskiy
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Publication number: 20070111317Abstract: An improved method of screening crystal growth conditions is provided wherein molecules are crystallized from solutions containing dyes. These dyes are selectively incorporated or associated with crystals of particular character thereby rendering crystals of particular character colored and improving detection of the dyed crystals. A preferred method involves use of dyes in protein solutions overlayed by oil. Use of oil allows the use of small volumes of solution and facilitates the screening of large numbers of crystallization conditions in arrays using automated devices that dispense appropriate solutions to generate crystallization trials, overlay crystallization trials with an oil, provide appropriate conditions conducive to crystallization and enhance detection of dyed (colored) or undyed (uncolored) crystals that result.Type: ApplicationFiled: December 15, 2006Publication date: May 17, 2007Inventors: Larry Cosenza, Terry Bray, Lawrence Delucas, Thomas Gester, David Hamrick
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Publication number: 20070026528Abstract: A method of screening protein crystal growth conditions with picogram to microgram amounts of protein in picoliter or nanoliter volumes is provided. A preferred method comprises a microarray with a plurality of micro-chambers in the microarray. A protein solution is placed into the micro-chambers by an automated dispensing mechanism. The protein crystal growth conditions of each of the micro-chambers is adjusted so that the protein crystal growth conditions in at least two of the micro-chambers differs. Crystallization of the protein solution in the micro-chambers is effected. Protein crystal growth in the micro-chambers is then observed.Type: ApplicationFiled: October 4, 2006Publication date: February 1, 2007Inventor: Lawrence DeLucas
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Patent number: 6861448Abstract: Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar1—X—Ar2—Y—L—Z—Q, wherein Q is Q1Ar3 or Ar3Q1; Ar1, Ar2, and Ar3 are independently aryl or heteroaryl, optionally substituted with one or more substituents; X, Y, and Z are independently selected from the group consisting of a covalent bond or groups containing one or more of C, H, N, O, S atoms; L is a linker and Q1 is an alkylenyl, alkylenyl carbonyloxy alkyl, or alkylenyl carbonylamino alkyl group, optionally having a substituent; a covalent bond; a group containing amidine or guanidine function wherein the amidine or guanidine may be optionally N-substituted with an alkyl; or a zwitterion; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 22, 2002Date of Patent: March 1, 2005Assignees: Virtual Drug Development, Inc., The UAB Research FoundationInventors: Wayne J. Brouillette, Lawrence DeLucas, Christie Brouillette, Sadanandan E. Velu, Yong-Chul Kim, Liyuan Mou, R. Stephen Porter
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Patent number: 6761861Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body. The protein crystal growth assembly may be employed in methods including vapor diffusion crystallization, liquid to liquid crystallization, batch crystallization, and temperature induction batch mode crystallization.Type: GrantFiled: February 1, 2002Date of Patent: July 13, 2004Assignee: UAB Research FoundationInventors: Robyn Rouleau, Lawrence Delucas, Douglas Keith Hedden
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Publication number: 20030232967Abstract: A method of screening solution conditions suitable for the crystallization of macromolecules with a picogram to a microgram of protein using picoliter or nanoliter volumes is provided. A preferred method comprises preparing a plurality of recipe solutions in milliliter volumes, aspirating protein and recipe solutions, respectively, from a plurality of wells, and dispensing the protein and recipe solutions into a plurality of wells, covering the combined protein and recipe solutions with oil, and maintaining the solution wells until crystallization or precipitation occur therein.Type: ApplicationFiled: October 23, 2002Publication date: December 18, 2003Inventors: Arnon Chait, Lawrence DeLucas, Brad Stoops, Alexander Belgovskiy
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Patent number: 6623708Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body.Type: GrantFiled: September 27, 2001Date of Patent: September 23, 2003Assignee: UAB Research FoundationInventors: Lawrence Delucas, Robyn Rouleau, Kenneth Banasiewicz
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Patent number: 6592824Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body.Type: GrantFiled: September 27, 2001Date of Patent: July 15, 2003Assignee: UAB Research FoundationInventors: Lawrence Delucas, Robyn Rouleau, Kenneth Banasiewicz
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Patent number: 6579358Abstract: A method of growing protein crystals in a protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethroug, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body. The method includes steps of rotating the cell barrel to orient the insert in a fill/removal position; loading and securing a protein into the insert; rotating the barrel to a launch configuration position; rotating the barrel to activate and experiment by placing the cell in a growth position; and then rotating the barrel further to deactivate the experiment.Type: GrantFiled: September 27, 2001Date of Patent: June 17, 2003Assignee: UAB Research FoundationInventors: Lawrence Delucas, Robyn Rouleau, Helen Powell, Barbara Williams
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Publication number: 20030083269Abstract: Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar1—X—Ar2—Y—L—Z—Q, wherein Q is Q1Ar3 or Ar3Q1; Ar1, Ar2, and Ar3 are independently aryl or heteroaryl, optionally substituted with one or more substituents; X, Y, and Z are independently selected from the group consisting of a covalent bond or groups containing one or more of C, H, N, O, S atoms; L is a linker and Q1 is an alkylenyl, alkylenyl carbonyloxy alkyl, or alkylenyl carbonylamino alkyl group, optionally having a substituent; a covalent bond; a group containing amidine or guanidine function wherein the amidine or guanidine may be optionally N-substituted with an alkyl; or a zwitterion; or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 22, 2002Publication date: May 1, 2003Applicant: Virtual Drug Development, Inc.Inventors: Wayne J. Brouillette, Lawrence DeLucas, Christie Brouillette, Sadanandan E. Velu, Yong-Chul Kim, Liyuan Mou, R. Stephen Porter
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Publication number: 20030003036Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body. The protein crystal growth assembly may be employed in methods including vapor diffusion crystallization, liquid to liquid crystallization, batch crystallization, and temperature induction batch mode crystallization.Type: ApplicationFiled: February 1, 2002Publication date: January 2, 2003Applicant: UAB RESEARCH FOUNDATIONInventors: Robyn Rouleau, Lawrence Delucas, Douglas Keith Hedden
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Patent number: 6447726Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body.Type: GrantFiled: August 10, 1999Date of Patent: September 10, 2002Assignee: UAB Research FoundationInventors: Lawrence Delucas, Robyn Rouleau, Kenneth Banasiewicz, Helen Powell, Barbara Williams, James Wayland, Todd Rentfrow
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Publication number: 20020122760Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having, a top side is disposed on the top side of the cell body.Type: ApplicationFiled: September 27, 2001Publication date: September 5, 2002Applicant: UAB RESEARCH FOUNDATIONInventors: Lawrence Delucas, Robyn Rouleau, Kenneth Banasiewicz
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Publication number: 20020106318Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body.Type: ApplicationFiled: September 27, 2001Publication date: August 8, 2002Applicant: UAB RESEARCH FOUNDATIONInventors: Lawrence Delucas, Robyn Rouleau, Kenneth Banasiewicz
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Publication number: 20020064485Abstract: A protein crystal growth assembly including a crystal growth cell and further including a cell body having a top side and a bottom side and a first aperture defined therethrough, the cell body having opposing first and second sides and a second aperture defined therethrough. A cell barrel is disposed within the cell body, the cell barrel defining a cavity alignable with the first aperture of the cell body, the cell barrel being rotatable within the second aperture. A reservoir is coupled to the bottom side of the cell body and a cap having a top side is disposed on the top side of the cell body.Type: ApplicationFiled: September 27, 2001Publication date: May 30, 2002Applicant: UAB RESEARCH FOUNDATIONInventors: Lawrence Delucas, Robyn Rouleau, Helen Kay Powell, Barbara Williams
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Patent number: 4223942Abstract: A vehicle sunroof comprised of a movable panel which is either transparent, translucent, opaque, or solid where movement is controlled by activation of an electric motor which causes the movable panel to drop down and slide rearward into an opening between the vehicle roof and the interior upholstry and which includes a light-weight housing, a transporting mechanism for providing purely vertical movement to the panel, a sealing means, a threaded shaft, forward and rear slide blocks, a slide plate, a riser bar, a verticle slide, all combined into a single, self-contained unit.Type: GrantFiled: August 9, 1978Date of Patent: September 23, 1980Inventor: Lawrence DeLuca